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Keywords: Pharmacokinetics
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Dig Dis (2015) 33 (Suppl. 1): 61–69.
Published Online: 14 September 2015
...Diane R. Mould Monoclonal antibodies (MAbs) exhibit complex pharmacokinetics (PK) and pharmacodynamics (PD, response) against tumor necrosis factor (TNF). Many factors impact anti-TNF MAb PK, altering MAb clearance and therefore the half-life: albumin, weight (particularly, obesity), disease...