...Naoshi Nishida; Masatoshi Kudo Hepatocellular carcinoma (HCC) is a major cause of cancer death, and its development is influenced by the status of inflammation and oxidative stress in the liver. Although oxidative stress might induce genetic changes and play a role in HCC development, many...

..., instructions or products referred to in the content or advertisements. Hepatocellular carcinoma Gender Fibrosis Hepatitis C Iron deposit Oxidative stress Genetics Epigenetics Hepatocellular carcinoma (HCC) is a common malignancy worldwide and the overall prevalence of the at-risk...

... role in regulation of cellular GSH that is vital to cellular antioxidant defense [ 14 ]. To determine if zinc supplementation protects against alcohol-induced oxidative stress and liver injury and if zinc action is independent of MT, MT-KO mice along with WT mice were pair-fed an alcohol liquid diet...

...A.K. Nussler; L. Hao; D. Knobeloch; P. Yao; N.C. Nussler; Z. Wang; L. Liu; S. Ehnert Background/Aims: Alcoholic liver disease is continuously increasing in developed countries being a leading cause of death worldwide. Chronic ethanol consumption induces oxidative stress by accumulation of reactive...

... mutations during the aging process, due to continuous mitochondrial ROS formation and ROS-induced mtDNA damage during the lifespan. Ethanol consumption causes oxidative stress in the liver as a consequence of free radicals and ROS formation in diverse organelles and cells [ 4,16 ]. In the cytosol...

...Arthur I. Cederbaum Background/Aims: Several pathways contribute to mechanisms by which ethanol induces oxidant stress. While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not. There is a need to develop oral models of significant ethanol-induced liver injury...

... the main mechanisms of fibrogenesis are independent of the etiology of liver injury, alcoholic liver fibrosis is distinctively characterized by a pronounced inflammatory response due to elevated gut-derived endotoxin plasma levels, an augmented generation of oxidative stress with pericentral hepatic...

... the general concept of nett free radical injury counterbalanced by antioxidants is discussed as oxidative stress. The role of oxidative stress in intestinal ischemia, radiation enteritis, inflammatory bowel disease and the promotion of gastric and colorectal cancer is discussed. The data for the role...