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Keywords: Opioids
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Journal Articles
Subject Area:
Dig Dis (1990) 8 (6): 361–373.
Published Online: 04 November 2008
...Wolfgang Kromer Opium alkaloids have been used for centuries as potent antidiarrheals and analgesics, their constipating action in the latter instance taken as an unwanted effect. It was only during the last decade that the physiological role of opioid peptides present in both neurons and endocrine...
Journal Articles
Subject Area:
Dig Dis (2006) 24 (1-2): 91–98.
Published Online: 12 May 2006
...Anthony Lembo Opioids have been used medicinally and recreationally for thousands of years. The clinical use of opioids for gastrointestinal conditions has been limited by central nervous system side effects. A new generation of peripheral opioid receptor ligands free of central nervous system side...