...; AST, aspartate aminotransferase; BSA, body surface area; CRP, C-reactive protein; Hb, hemoglobin; LDA, low-dose aspirin; NSAIDs, nonsteroidal anti-inflammatory drugs; WBC, white blood cell count. Of the 117 patients included in the analysis, 10 (8.5%) had gastroduodenal ulcers ( Table 2...

... efficacy of traditional nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit COX-1 and/or COX-2, has considerable support from animal and epidemiological studies; however, there are well-documented toxicities associated with NSAID use. These adverse effects are attributed to NSAIDs’ inhibition...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nonsteroidal anti-inflammatory drugs Gastroduodenal damage...

...Carmelo Scarpignato Gastroduodenal mucosa possesses an array of defensive mechanisms and nonsteroidal anti-inflammatory drugs (NSAIDs) have a deleterious effect on most of them. This results in a mucosa less able to cope with even a reduced acid load. The presence of acid appears to be a conditio...

...Cleo Lancaster All nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal (GI) side effects. One focus of development was to design new drugs with reduced propensity for GI damage. With aspirin as the prototype, research efforts to develop NSAIDs with the efficacy...

...Maurizio Koch; Lucio Capurso; Angelo Dezi; Fabio Ferrario; Carmelo Scarpignato In order to provide a systematic overview of the available information on the prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal mucosal injury, we performed a meta-analysis based on all...

...Graham Pipkin; Jane G. Mills Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment for rheumatic diseases. However, a significant number of patients receiving these drugs experience upper gastrointestinal side effects, including physical injury to the gastroduodenal mucosa...

...Kurt R. Bernsdorff; Radheshyam M. Agrawal; George J. Brodmerkel, Jr. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is extensive, and the upper gastrointestinal (GI) side effects of these drugs have been well recognized. Although much attention has been focused on gastroduodenal...

...David J. Bjorkman; Michael B. Kimmey Nonsteroidal anti-inflammatory drugs (NSAIDs) are a common cause of gastrointestinal ulceration. Chronic NSAID use increases the risk of ulcer bleeding or perforation 3- to 4-fold. NSAID-induced injury results from both local effects and systemic prostaglandin...

...James M. Scheiman Nonsteroidal anti-inflammatory drugs (NSAIDs) initiate gastroduodenal ulceration and promote complications such as bleeding and perforation. Age greater than 60 years, a prior history of ulcer disease, and concomitant corticosteroid use are important risk factors for ulcer...

...Margrit Hollenz; Manfred Stolte; Andreas Leodolter; Joachim Labenz Background and Aim: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause dyspeptic complaints and lesions in the upper gastrointestinal tract. The true incidence of these side effects in the everyday situation remains uncertain. We...