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Keywords: Monoclonal antibodies
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Journal Articles
Dig Dis (2016) 34 (1-2): 153–159.
Published Online: 16 March 2016
.... Natalizumab, a monoclonal antibody to the α4 integrin, was approved for the treatment of multiple sclerosis and showed promise in Crohn's disease (CD), however it is encumbered by the risk of progressive multifocal leukoencephalopathy. Vedolizumab inhibits the α4β7 integrin to induce clinical remission...
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Dig Dis (2015) 33 (Suppl. 1): 61–69.
Published Online: 14 September 2015
...Diane R. Mould Monoclonal antibodies (MAbs) exhibit complex pharmacokinetics (PK) and pharmacodynamics (PD, response) against tumor necrosis factor (TNF). Many factors impact anti-TNF MAb PK, altering MAb clearance and therefore the half-life: albumin, weight (particularly, obesity), disease...
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Dig Dis (1993) 11 (6): 334–342.
Published Online: 04 November 2008
..., while newer immunosuppressives such as methotrexate, FK 506 and monoclonal antibodies against helper T lymphocytes show some early promise. 4 11 2008 © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...