...Se Peng; Qingrong Wu; Xiaoting Huang; Xuehua He; Zhong Li; Jianfeng Xu; Lei Wang; Jialing Zhuang Background: The assessment of liver fibrosis has been a critical component in the clinical management of liver diseases. We performed a meta-analysis to evaluate serum Golgi protein 73 (GP73...

... and mortality. Due to the high and increasing prevalence of NAFLD, there is an urgent need to identify people at risk of developing liver fibrosis and complications. CC-chemokine ligand 2 (CCL2) is chemokine that attracts inflammatory monocytes to stressed or injured tissues. Infiltrating inflammatory monocytes...

..., instructions or products referred to in the content or advertisements. Hepatocellular carcinoma Liver fibrosis Prognosis Mortality Diabetes Affecting more than 250 million individuals worldwide, chronic infection with the hepatitis B virus (HBV) is a leading cause of adverse liver-related...

... and January 2020. Demographic, clinical, and laboratory data and TE parameters were prospectively obtained. EKD was defined as microalbuminuria (urinary albumin-to-Cr ratio 30–300 mg/g) and estimated glomerular filtration rate ≥60 mL/min/1.73 m 2 . Significant liver fibrosis was defined as liver stiffness...

... analysis showed high diagnostic accuracy in the assessment of fibrosis, and it appears to be a useful diagnostic tool for noninvasive quantification of fibrosis in patients with chronic viral hepatitis. [email protected] 8 06 2017 14 08 2017 26 4 2018 Liver fibrosis...

...Li Bai; Waishu Jin; Ming Kong; Xiaohui Zhang; Sujun Zheng; Yu Chen; Lu Li; Hui Liu; Longdong Zhu; Feng Ren; Junfeng Li; Yuanping Han; Zhongping Duan Background: Injury resistance occurring in the setting of liver fibrosis is an interesting phenomenon not yet well characterized. In the present study...

...Tao Wu; Ping Wang; Ting Zhang; Jian Zheng; Shuoyang Li; Jie Zeng; Masatoshi Kudo; Rongqin Zheng Background: Noninvasive assessment of liver fibrosis has important clinical significance. Different techniques including two-dimensional shear-wave elastography (2D SWE) and real-time tissue elastography...

...Yukinori Koyama; Jun Xu; Xiao Liu; David A. Brenner Liver fibrosis results from many chronic injuries and often progresses to cirrhosis, liver failure, portal hypertension, and hepatocellular carcinoma. Liver transplantation is the only treatment available for patients with advanced stages of liver...

.... Liver fibrosis Macrophages Chemokine Matrix Regression Translational medicine Hepatic stellate cell Myofibroblast Gut-liver axis Microbiome Perpetuating liver damage leads to fibrosis and cirrhosis representing a common and difficult clinical challenge. Clinical hepatologists...

...Laurent Castera Background: The prognosis and management of chronic liver diseases greatly depend on the amount and progression of liver fibrosis with the risk of developing cirrhosis. Liver biopsy, traditionally considered as the reference standard for the staging of fibrosis, has been challenged...

..., instructions or products referred to in the content or advertisements. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Insulin resistance Visceral fat NAFLD and NASH are both characterized by an accumulation of fat, mainly in the form of triglycerides...

... a specific role for the induction of fibrogenesis in this condition. In this paper, we review recent developments regarding the basic mechanisms of NASH and the involvement of hepatic stellate cells in this disease. Non-alcoholic steatohepatitis Hepatic stellate cells Liver fibrosis Adipokines ©...

...Sören V. Siegmund; Steven Dooley; David A. Brenner Alcohol abuse is a major cause of liver fibrosis and cirrhosis in developed countries. Before alcoholic liver fibrosis becomes evident, the liver undergoes several stages of alcoholic liver disease including steatosis and steatohepatitis. Although...