...Detlef Schuppan; Victor Zevallos While the central role of an adaptive, T cell-mediated immune response to certain gluten peptides in celiac disease is well established, the innate immune response to wheat proteins remains less well defined. We identified wheat amylase trypsin inhibitors (ATIs...

... cells based on quantitative assessment of mRNA [40]. b Comparisons of in vitro and in vivo activities of the two most abundant antimicrobial peptides of human Paneth cells, α-defensin HD5 and HD6 [24,27,28,41]. Innate immunity in the intestine includes multiple mechanisms, including (i...

...Thomas Klag; Eduard F. Stange; Jan Wehkamp The pathogenesis of inflammatory bowel disease (IBD) is very complex, including a variety of genetic and environmental contributing factors. In this context, over the past few years, a picture of IBD as a primary defect of the innate immune system rather...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Innate immunity Hepatitis C NK cells HCV The hepatitis C virus (HCV) was first described in 1989 [ 1 ]. HCV infection causes hepatitis C, an inflammatory liver disease with a high rate...

...Miles Parkes The early identification of NOD2 (nucleotide-binding oligomerization domain-containing protein 2) as a susceptibility gene for Crohn’s disease first catalysed major interest in the role of innate immunity in IBD. This interest has been substantiated by genome-wide association studies...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Inflammation Innate immunity Hepatocellular cancer Carcinogenesis Cytokine Hepatitis C virus Hepatitis B virus NF-ĸB Cirrhosis Hepatocellular cancer (HCC) represents...

... disease Genetics Innate immunity Pattern recognition receptors NOD-like receptors Autophagy Inflammation Crohn’s disease (CD) is a multifactorial and heterogeneous chronically relapsing inflammatory bowel disease that is thought to result from an inappropriate inflammatory response towards...

... microbiota Innate immunity Adaptive immunity Colorectal cancer Probiotics The adaptive immune response to normal gut bacteria is part of a homeostatic process that is neither ignorance nor tolerance. The gut-mucosal arm of the adaptive immune system, localized predominantly in the small bowel...

... from immune tolerance to immune clearance are hardly understood. The innate immune response, early adaptive B and T cell responses, regulatory T cells, the liver microenvironment, and the peculiar properties of hepatocytes and nonparenchymal liver cells to present antigen seem to play a role...

...Mark G. Swain Natural killer T (NKT) cells are distinct innate immune T cells which play a key role in the pathogenesis of various immune-mediated liver diseases. NKT cells are traditionally defined as cells that co-express the T cell receptor (TCR) and certain natural killer cell surface markers...

... host that initially derives from innate immune abnormalities leading to an excessive proinflammatory cytokine derived from CD4+ T cells (T-helper 1, T-helper 2, and T-helper 17 cytokines) over and above the response that is normally associated with tolerance and immunoregulation derived from T...

... Innate immunity Crohn’s disease 24 9 2009 © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...