...Valeria Maccauro; Francesca Fianchi; Antonio Gasbarrini; Francesca Romana Ponziani Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of unknown etiology characterized by biliary inflammation and periductal fibrosis. The gut microbiota plays a crucial role...

... Biomarker Inflammation Non-alcoholic fatty liver disease (NAFLD) is a chronic inflammatory disease caused by sustained injury to the liver parenchyma as a result of ectopic fat accumulation in the liver. As the liver manifestation of the metabolic syndrome, NAFLD affects an estimated 30% of people...

... and mild inflammation is difficult to visually determine using the updated Sydney system scale of gastritis. Additionally, eosinophils in the gastric mucosa must be counted to diagnose eosinophilic gastritis. We aimed to determine the normal number of inflammatory cells in patients with endoscopically...

...Stefan Reischl; Jasmin Troger; Moritz Jesinghaus; Atsuko Kasajima; Dirk Felix Wilhelm; Helmut Friess; Philipp-Alexander Neumann Introduction: Crohn’s disease (CD) is characterized by relapsing intestinal inflammation. The anti-inflammatory protein annexin A1 (ANXA1) has been linked to inflammatory...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatic encephalopathy Cirrhosis Inflammation Ammonia Cytokine profile Hepatic encephalopathy (HE) is a sign of end-stage liver disease...

... with anti-ADA antibodies or with interleukin concentrations of inflammation, and other publications on different techniques of analysis of ADA levels. After the selection process, the number of references finally selected for review was 11. Serum ADA quantification used in combination with clinical data...

... and investigate if genotype influences biochemical markers of inflammation. Summary: Patients were included from a population-based pediatric IBD cohort from Eastern Denmark. Data on biochemical markers and medical as well as surgical treatment were registered at diagnosis, 30 days, 6 and 12 months after...

... to in the content or advertisements. Herbs Herbal drugs Bitter drugs Aromatic drugs Spasmolysis Inflammation Combination medicines Judging by the historic medicinal literature, functional gastrointestinal diseases (FGID) have always been an issue in the history of mankind, and herbal...

... mechanisms for gut-brain dysfunction have been identified, with systemic minimal inflammation as a causal factor in at least some subjects. Other mechanisms that play a role in FGID include chronic infections, intestinal microbiota, low-grade mucosal inflammation including the increase of eosinophils...

...-based approaches is yet to be experienced. Notwithstanding this, the etiological background of hepatobiliary cancer - overlapping in almost every known causative or associated factor with inflammation - provides a strong clue that these approaches may have an impact on this group of diseases...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Bile acid Cholestasis Inflammation...

... fibrosis. Therefore, new strategies for anti-fibrotic therapy are required. Various kinds of hepatocyte damage result in inflammation, which leads to the activation of hepatic stellate cells (HSCs), which are the major source of myofibroblasts in the liver. Myofibroblasts proliferate in response to various...

... like F. prausnitzii is associated with better clinical outcomes, especially in adult IBD patients. However, despite these advances in our understanding of the mechanistic implications of dysbiosis, whether this dysbiosis is a cause or consequence of inflammation in IBD patients remains unresolved. We...

... of IBD are on the rise within the last few years, especially in non-western countries. One of those factors is believed to be hypoxia. The role of hypoxia as a modifying or even causative factor in the genesis and maintenance of inflammation has been increasingly elucidated in recent years. Hypoxia...

... inflammation and defective adaptation of biliary composition (bicarbonate and chloride). Most importantly, TGR5-KO mice had a more hydrophobic BA pool, with more secondary BA than WT animals, suggesting that TGR5-KO bile may be harmful for the liver, mainly in situations of BA overload. As GB is both...

...Sumera Rizvi; Gregory J. Gores It has become increasingly apparent of late that inflammation plays an integral role in a spectrum of malignancies including cholangiocarcinoma (CCA). Primary sclerosing cholangitis with chronic inflammation is the most common risk factor for CCA in the Western world...

... the pathophysiology of the underlying inflammation. Results and Conclusions: Evidence has accumulated that EoE represents a T-helper (Th) 2-type inflammatory disease, in which allergens play a role in triggering the disease. The majority of the patients suffer from concurrent allergic rhinitis, asthma, and eczema...

...Hirokazu Okayama; Aaron J. Schetter; Curtis C. Harris There is a strong connection between inflammation, altered microRNA (miRNA) expression and colon cancer. Longstanding inflammatory bowel diseases-related colitis leads to increased risk for the development of colorectal cancer (CRC), while...

... homeostasis (i.e. health) and disease, especially in obesity-related disorders such as non-alcoholic fatty liver diseases (NAFLD) and their complications, including hepatocellular carcinoma (HCC). Lack of adiponectin as observed in NAFLD drives steatosis and inflammation in the liver, and evidence...

.... However, current systemic molecular therapies against HCC are mainly focusing on tyrosine kinases involved in angiogenic and oncogenic signaling pathways, whereas the knowledge on the unique association between inflammation and carcinogenesis in the liver has not yet translated into preventive...