... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatocellular carcinoma DNA methylation Histone Chromatin Mutation It has been well described that the accumulation of genetic and epigenetic changes leads...

... that the proportion of hepatocellular carcinoma (HCC) without hepatitis virus infection (NBNC-HCC) is increasing. On the other hand, epigenetic alterations are reportedly responsible for HCC development. Here, we identified HCC risk factors that are associated with DNA methylation in the background liver tissue...

...Naoshi Nishida; Hirokazu Chishina; Tadaaki Arizumi; Masahiro Takita; Satoshi Kitai; Norihisa Yada; Satoru Hagiwara; Tatsuo Inoue; Yasunori Minami; Kazuomi Ueshima; Toshiharu Sakurai; Masatoshi Kudo Objectives: DNA methylation-dependent transcriptional inactivation of tumor suppressor genes (TSGs...

... consisting of 59 HCC and 58 noncancerous livers. Altered DNA methylation patterns during tumor progression were also analyzed. Results: We identified 38,330 CpG sites with significant differences in methylation levels between HCCs and noncancerous livers (DM-CpGs) using strict criteria. Of the DM-CpGs, 92...

... of homocysteine that is used in the synthesis of GSH, increased production of GSH leads to the decrease of SAM necessary for maintaining the DNA methylation and the emergence of global DNA hypomethylation [ 64 ]. 8-Oxo-7,8-dihydroguanine (8-oxodG) has been regarded as the most reliable marker of DNA damage...

.... Unfortunately, patient adherence to colonoscopy is poor, which is partially due to the modest performance of currently used prescreening tests. Recently, epigenetics added an additional layer to the understanding of colorectal carcinogenesis. DNA methylation as part of the epigenetic gene-silencing complex...