... and their biological rationale, diagnostic, and clinical value. [email protected] The cytokine IL-1ß was chosen because of its central role in inflammatory diseases such as IBD. It is well known that glucocorticoids released during stress have a significant downregulatory effect on IL-1ß [ 10...

...Beatriz Mateos; Esteban Sáez-González; Inés Moret; David Hervás; Marisa Iborra; Elena Cerrillo; Luis Tortosa; Pilar Nos; Belén Beltrán Background: Cytokines emerge as possible biomarkers of response in Crohn’s disease (CD). We aimed to determine the plasmatic cytokine profiles of active CD patients...

..., patients with cirrhosis may be subjected to scheduled examination of ascitic fluid cytokines to predict transformation into HCC. © 2021 S. Karger AG, Basel 2021 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

... is <10 μ M , indicating there must be alternative mechanisms. Recent studies suggest that the inflammatory response may play an important role in bile acid-induced liver injury, as pro-inflammatory cytokine expression is stimulated by bile acids in mouse hepatocyte cultures. To elucidate the mechanisms...

... involved in function of the cag TFSS were differentially regulated when comparing H. pylori strains isolated from iron-depleted vs. iron-replete gerbils [ 39 ] and levels of phosphorylated CagA (reflecting translocated CagA), the number of cag T4SS pili, and induction of pro-inflammatory cytokines...

..., mucosal immune cells appear to be activated by the commensal microflora in a genetically susceptible host leading to uncontrolled proinflammatory cytokine production and subsequent tissue destruction [ 4, 5, 6, 7, 8 ]. Complications of IBD may comprise development of stenoses, stricture formation...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Allergy Cytokines Eosinophilic esophagitis Inflammation In a broad spectrum of inflammatory diseases, eosinophils are found among infiltrating cells [ 1,2 ]. For example...

.... Whereas targeting of activated CD4 + T cells by specific antibody strategies or neutralization of key T-cell cytokines such as IL-2 or IFN-γ has not been effective in human IBD, blocking migration of activated leukocytes, e.g. T cells into the inflamed tissue by specific antibodies such as vedolizumab...

... therapy have been developed in animal models, including strategies against proinflammatory cytokines, signaling pathways and adhesion molecules. Conclusion: New animal models of IBD have illuminated some aspects of IBD pathogenesis and suggest new avenues for therapy of IBD. 11 10 2012 © 2012...

... models will propagate the understanding of NASH and help clinicians to develop new treatment modalities. 7 5 2010 Animal models Non-alcoholic steatohepatitis Metabolic syndrome Insulin resistance Cell death Cytokines © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage...

...Jørn Brynskov; Ole Haagen Nielsen; Ian Ahnfelt-Rønne; Klaus Bendtzen Cytokines, particularly the proinfiammatory cytokines, whose role and natural regulation in inflammatory bowel disease are reviewed here, are produced by many cell types, including immune cells. Cytokines function as important...

...-sense Cytokines Growth factors Review Article Dig Dis 2003;21:180 191 DOI: 10.1159/000073249 Biological Therapy in IBD Anti-Tumor Necrosis Factor-Alpha and Others Jürgen Schölmerich Gertrud Huber Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany Key Words...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Cytokines Immunity Bacteria Immunopathogenesis T cells Vaccines Inflammatory bowel disease Review Article Dig Dis 2001;19:104 111 Helicobacter pylori Infection as a Model for Gastrointestinal...

.... Such investigations indicate that chronic liver damage is associated with replication of mesenchymal, ductular and parenchymal cells, accompanied by increased fibrogenesis. The regenerative response of the liver after noxious injury in experimental animals and man is associated with the release of cytokines, increase...