... with biopsy and 118,396 matched patients without biopsy were analyzed. The incidence per 1,000 person-years for hepatocellular carcinoma (HCC) was 0.22 versus 2.18, cirrhosis 29.75 versus 90.44, and hepatic decompensation 15.84 versus 28.25 compared patients with and without biopsy. In multivariable analysis...

... of liver diseases has changed significantly, but its impact on the comparative burden of cirrhosis between males and females is unclear. We estimated sex differences in the burden of cirrhosis across 204 countries and territories from 2010 to 2019. Methods: We analyzed temporal trends in the burden...

... Care Unit Severity Score (ImCUSS) were calculated in patients with cirrhosis ( n = 98) at ImCU admission. Discrimination performances were evaluated by area under the receiver operating characteristic curves (AUROCs), calibration performances with calibration belt plots, and their corresponding p...

... to investigate the natural history of cirrhosis and to determine trends in the etiology of cirrhosis. Methods: Between January 2001 and January 2018, a total of 1,341 patients had been diagnosed with cirrhosis and were included. Results: A total of 898 cirrhotic patients, who were followed up for at least 6...

...Ioannis Bellos; Konstantinos Kontzoglou; Amanda Psyrri; Vasilios Pergialiotis Background and Aims: Refractory ascites represents a significant complication of decompensated cirrhosis, associated with increased mortality rates. The aim of this meta-analysis was to evaluate whether response...

..., a proinflammatory component has been suggested as precipitating event. Objectives: To evaluate the role of cytokines in cirrhosis for development of HE. Methods: Pro- and anti-inflammatory cytokine profiles were determined in rats with CCL 4 -induced cirrhosis and HE as well as in patients with cirrhosis either due...

... with ascites. Methods: Overall, 99 patients with newly diagnosed ascites with cirrhosis were enrolled. No patients had intrahepatic malignancy. The patients were divided into 2 groups based on tolvaptan therapy: 86 patients treated with tolvaptan (tolvaptan-group) and 13 patients treated without tolvaptan (non...

...) bridging; F4, fibrosis expansion of portal areas with marked P–P bridging as well as portal to central (P–C); F5, marked bridging (P–P and P–C) with occasional nodules (incomplete cirrhosis), and F6, cirrhosis. [ 10 ] In the elastographic study, we divided the patients into 2 different categories...

...Xiao-wen Huang; Bing Liao; Yang Huang; Jin-yu Liang; Quan-yuan Shan; Shun-li Shen; Xiao-yan Xie; Ming-de Lu; Li-da Chen; Wei Wang Aim: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas...

...Ian A. Rowe Liver cirrhosis is responsible for more than 1 million deaths annually and the majority of these deaths are preventable. There is marked geographical variation in rates of mortality due to cirrhosis, and this variation in liver disease burden exemplifies the links between population...

...Elisa Pose; Andres Cardenas Ascites is the most common complication associated with cirrhosis resulting in poor quality of life, high risk of development of other complications of cirrhosis, increased morbidity and mortality associated with surgical interventions, and poor long-term outcome...

... the mainstays of academic hepatology practice, where do we go from here? Unfortunately, we are in an era where the incidence and prevalence of liver diseases around the globe is increasing, and death from complications of cirrhosis is now among the top 10 causes in most countries; so hepatologists are expected...

...Francesca Saffioti; Massimo Pinzani Liver cirrhosis is the ultimate consequence of the wound healing reaction subsequent to a chronic injury, which leads to a complete derangement of the normal hepatic lobular and vascular architecture. Cirrhosis is characterized by patterns of evolution depending...

...Katherine Arndtz; Gideon M. Hirschfield Background: Autoimmune liver disease (AILD) encompasses 3 main distinct clinical diseases: autoimmune hepatitis, primary biliary cholangitis (formally known as cirrhosis, PBC) and primary sclerosing cholangitis (PSC). These conditions are an important, yet...

.... Curry et al. [ 16 ] reported results of the first IFN-free regimen in 61 enlisted patients with compensated cirrhosis using the pangenotypic NS5B polymerase inhibitor sofosbuvir (SOF) combined with RBV. The authors showed an impressive rate of HCV infection prevention (70% achieved SVR after LT...

... with chronic HEV infection have no symptoms, but some develop rapidly progressive liver cirrhosis. The full clinical spectrum of HEV is still emerging. HEV has important extra-hepatic manifestations, which deserve further investigation. For example, HEV can cause a wide range of neurological illness...

...Guadalupe Garcia-Tsao Cirrhosis is not a single entity but represents a disease progression across different prognostic stages, with the compensated and decompensated stages being the most important. Variceal hemorrhage (VH) and ascites are complications of cirrhosis that denote the presence...

...M. Omar Farooq; Ramon Bataller Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality. ALD encompasses a spectrum of disorders ranging from asymptomatic steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis and its related complications. Moreover, patients can...

...Raoul Poupon PBC (formerly known as primary biliary cirrhosis and now named primary biliary cholangitis) is a disease with a wide range of severity and variable rate of progression. The diagnosis of advanced liver fibrosis/cirrhosis portends an increased risk of liver-related morbidity...

... elusive at imaging, which is a critical issue in cirrhotic patients in whom a diagnosis of hepatocellular carcinoma (HCC) can be established only by imaging. Aim: The aim of the study was to evaluate the potential of MRI in the diagnosis of ICC in cirrhosis using ‘hepatocyte-specific' Gadolinium (Gd...