...Stephanie Hawkins; Meghali Nighot; Shannon Dalessio; Junjia Zhu; Nathan Morris; Kofi Clarke Introduction: We sought to evaluate the effect of proton pump inhibitor (PPI) use on the development and severity of iron deficiency anemia (IDA) in celiac disease (CD). Methods: We conducted a retrospective...

...Niranjani Venkateswaran; Benjamin Claxton; David Locke; Allison Baragona; Erik B. Lehman; Shannon Dalessio; Kofi Clarke Background: Strict adherence to a gluten-free diet is the only known effective treatment for celiac disease currently. Multiple organizations recommend follow-up with a dietitian...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. NET Celiac disease Inflammatory bowel diseases Treatment Diagnosis...

...Nevzat Aykut Bayrak; Burcu Volkan Objectives: Data regarding Helicobacter pylori (Hp) infection frequency in concurrent celiac disease (CD) and type 1 diabetes mellitus (T1DM) (CD + T1DM) are anecdotal. This study aimed to evaluate the association between Hp and concomitant CD + T1DM in children...

...Navchetan Kaur; Sanjay K. Bhadada; Ranjana W. Minz; Devi Dayal; Rakesh Kochhar Background: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic...

...Nurit Loberman-Nachum; Michael Schvimer; Camila Avivi; Iris Barshack; Avishay Lahad; Akiva Fradkin; Yoram Bujanover; Batia Weiss Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue...

..., and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). Methods: Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria...

...George J. Kahaly; Detlef Schuppan Background: Celiac disease (CD) is a small-intestinal inflammatory disease that is triggered by the ingestion of the storage proteins (gluten) of wheat, barley and rye. Key Messages: Endocrine autoimmunity is prevalent in patients with CD and their relatives...

...Govind K. Makharia Until 1970s, celiac disease (CD) was considered to be an uncommon disease except in Western Europe. The global epidemiology of CD continues to evolve with improvement in the diagnostic tests, simplification of the diagnostic criteria and increase in awareness about the disease...

...M. Luisa Mearin Several studies have suggested a protective role of breastfeeding and/or the timing and quantity of gluten introduction in the subsequent development of celiac disease. Especially, prolonged breastfeeding during the introduction of gluten-containing feeding has been associated...

...María Inés Pinto-Sánchez; Premysl Bercik; Elena F. Verdu; Julio C. Bai Case finding for celiac disease (CD) is becoming increasingly common practice and is conducted in a wide range of clinical situations ranging from the presence of gastrointestinal symptoms to failure to thrive in children...

...Katri Kaukinen; Katri Lindfors Currently, the only effective treatment for celiac disease is a strict lifelong gluten-free diet. However, gluten-free dieting is restrictive, difficult to maintain and nutritionally less than optimal. The improved knowledge on celiac disease pathogenesis has enabled...

...Marlou Adriaanse; Daniel A. Leffler The advent of highly reliable noninvasive celiac diagnostic tests has transformed the field of celiac disease, from diagnosis, to evaluation of epidemiology, to clinical and translational research. Serologic tests in their modern forms are highly sensitive...

...Ludvig M. Sollid; Rasmus Iversen; Øyvind Steinsbø; Shuo-Wang Qiao; Elin Bergseng; Siri Dørum; M. Fleur du Pré; Jorunn Stamnaes; Asbjørn Christophersen; Inês Cardoso; Kathrin Hnida; Xi Chen; Omri Snir; Knut E.A. Lundin Background: Celiac disease is a multifactorial and polygenic disease...

...Mauro Rossi Background: Celiac disease (CD) results from an alteration in the oral tolerance to dietary gluten. The response to gluten is normally tightly regulated and involves the secretion of TGF-β and IL-10 from different subtypes of regulatory T cells (Tregs). Interestingly, in addition...

...Emanuele Rondonotti; Silvia Paggi Background: Because of its technical characteristics (i.e. 8-fold magnification, capability to inspect the entire small bowel) and minimal invasiveness, videocapsule endoscopy (VCE) has been proposed as a useful tool for managing patients with celiac disease (CD...

...Maria Ines Pinto-Sanchez; Premysl Bercik; Elena F. Verdu Regulation of gut motility is complex and involves neuromuscular, immune and environmental mechanisms. It is well established that patients with celiac disease (CD) often display gut dysmotility. Studies have shown the presence of disturbed...

...Bertrand Meresse; Natalia Korneychuk; Georgia Malamut; Nadine Cerf-Bensussan Background: The immune response causing celiac disease (CD) depends on the activation of intestinal CD4+ T cells by gluten-derived peptides presented by HLA-DQ2 or HLA-DQ8 molecules, the main genetic risk factor. However...

...Carlo Catassi; Simona Gatti; Elena Lionetti In Europe and the USA, the mean frequency of celiac disease (CD) in the general population is approximately 1%, with some regional differences, the reasons for which remain elusive. A similar disease prevalence has been found in other countries mostly...

...Stijn J.B. Van Weyenberg; Chris J.J. Mulder; Jan Hein T.M. Van Waesberghe Background: Modern small bowel imaging techniques allow detailed depiction of small-intestinal abnormalities. The role of these techniques in the investigation of celiac disease is increasing, especially in patients...