... reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett’s esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant...

... Gastrointestinal microbiome Barrett’s esophagus NIH In the US alone, it is estimated that 18,440 new cases of esophageal cancer will be diagnosed in 2020 and 16,170 deaths are expected from the disease [ 1 ]. Likewise, the incidence, prevalence, and the health-care burden related to the benign...

...Luka Vranić; Tin Nadarević; Davor Štimac Background: Barrett’s esophagus (BE) requires surveillance to identify potential neoplasia at an early stage. The standard surveillance regimen includes random 4-quadrant biopsies by Seattle protocol. Main limitations of random biopsies are high risk...

...Jagpal Singh Klair; Yousaf Zafar; Navroop Nagra; Arvind R. Murali; Mahendran Jayaraj; Dhruv Singh; Tarun Rustagi; Rajesh Krishnamoorthi Background: Endoscopic therapy using radiofrequency ablation (RFA) is a recommended treatment for Barrett’s esophagus with high-grade dysplasia (BE-HGD) without...

...Jia Di; Yan Cheng; Danyan Chang; Yan Liu Background and Aim: The etiology and pathogenesis of Barrett’s esophagus (BE) have been widely studied during recent decades. However, the association between BE and possible risk factors, including abdominal obesity (AO), metabolic syndrome (MetS), insulin...

...Roy C. Orlando Background/Aims: Endoscopic radiofrequency ablation of dysplastic Barrett's esophagus (BE) combined with proton pump inhibitor therapy is commonly utilized for preventing progression of dysplastic BE to esophageal adenocarcinoma. Fundamental to the success of this and all ablative...

...Stuart Jon Spechler Barrett's esophagus, the condition in which metaplastic columnar epithelium that predisposes to cancer development replaces the squamous epithelium that normally lines the distal esophagus, is a complication of gastroesophageal reflux disease (GERD). Metaplasia is a potentially...

...Oliver Pech The cancer risk of nondysplastic Barrett's esophagus is very low (0.33-0.5 per year). Therefore, any endoscopic ablation technique is an overtreatment. Patients with low-grade intraepithelial neoplasia confirmed by a specialized GI pathologist seem to have a significant risk...

...Stuart Jon Spechler The American Gastroenterological Association (AGA) defines Barrett's esophagus as the condition in which any extent of metaplastic columnar epithelium that predisposes to cancer development replaces the squamous epithelium that normally lines the distal esophagus. Although...

... also to the association between obesity, Barrett’s esophagus and esophageal adenocarcinoma development. 20 6 2012 © 2012 S. Karger AG, Basel 2012 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

...F. Kastelein; M.C.W. Spaander; K. Biermann; B. Vucelic; E.J. Kuipers; M.J. Bruno Barrett’s esophagus (BE) usually develops in patients with gastroesophageal reflux disease and therefore it has been suggested that esophageal acid exposure plays an import role in the initiation of BE and its...

... than esomeprazole. S-tenatoprazole-Na may provide greater clinical efficacy compared with current PPIs for patients with ineffective once-daily therapy [ 10 ]. The prevalence of Barrett’s esophagus is 6–12% of all patients who present for endoscopy with GERD-related symptoms, and 0.25–3.9...

...Amnon Sonnenberg Background: Gastroesophageal reflux disease (GERD) is comprised of a spectrum of related disorders, including hiatal hernia, reflux disease with its associated symptoms, erosive esophagitis, peptic stricture, Barrett’s esophagus, and esophageal adenocarcinoma. Besides multiple...

...Kafia Belhocine; Jean-Paul Galmiche The complications of gastroesophageal reflux disease (GERD) include ulcers, strictures, Barrett’s esophagus and carcinoma. Although the prevalence of GERD is very high, the development of complications remains quite rare and usually occurs in association...

...Helmut Neumann; Klaus Mönkemüller; Michael Vieth; Peter Malfertheiner Barrett’s esophagus (BE) is established as the primary precursor lesion of esophageal adenocarcinoma (EAC). The risk of esophageal cancer is 30–125 times greater compared to an age-matched population and survival rates are low...

...László Herszényi; István Pregun; Zsolt Tulassay Barrett’s esophagus (BE) is the precursor lesion of esophageal adenocarcinoma, a malignancy with increasing incidence in Western countries. Malignant transformation of Barrett’s metaplasia is a multistep process in which intestinal metaplasia...

...Jaroslaw Regula Screening and surveillance of Barrett’s esophagus is a matter of discussion in the current world literature due to uncertainties concerning its cost-effectiveness. Important and valid arguments for and against it are available. Despite the fact that this issue is still...

...Örs Péter Horváth; Katalin Kalmár Adenocarcinomas in Barrett’s esophagus are increasingly diagnosed at early stages thanks to effective surveillance programs. Subtotal esophagectomy with extended lymphadenectomy is considered the best curative treatment for patients with early adenocarcinoma...

...David E. Fleischer; Virender K. Sharma There is increasing interest in the endoscopic treatment of Barrett’s esophagus. Endoscopic treatment has been utilized for many years, but in the past, no specific method has emerged as an appealing treatment option with appropriate safety, efficacy and ease...

.... Endoscopic resection Endoscopic submucosal dissection Barrett’s esophagus Squamous cell carcinoma Early gastric neoplasia Dig Dis 2008;26:285 290 DOI: 10.1159/000177010 Endoscopic Resection of Early Esophageal and Gastric Neoplasias Juergen Pohl Oliver Pech Andrea May Hendrik Manner Christian Ell...