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Keywords: Autoimmune hepatitis
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Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2017) 35 (4): 323–333.
Published Online: 03 May 2017
... risk factors are in fact inseparable and can harbour mechanistic insight for each factor on disease processes. Phenylketonuria Tyrosinemia Cystic fibrosis Drug-induced liver injury Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Cystic fibrosis...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2016) 34 (4): 334–339.
Published Online: 11 May 2016
...Christina Weiler-Normann; Ansgar W. Lohse The term ‘overlap syndrome' has been used to describe the presence of both autoimmune hepatitis and primary biliary cholangitis or primary sclerosing cholangitis in the past. As this term is misleading, the term ‘variant syndrome' should be used preferably...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 88–93.
Published Online: 07 December 2015
...Gerd Bouma; Carin M. van Nieuwkerk Background: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disorder of unknown aetiology, which when left untreated can lead to liver cirrhosis and hepatic failure. Current treatment strategies include long-term treatment with corticosteroids...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 13–24.
Published Online: 07 December 2015
...Tom H. Karlsen; Brian K. Chung Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) have collectively been recognized as autoimmune liver diseases. They have all been subjected to genome-wide association studies (GWAS) and several dozens...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 181–187.
Published Online: 07 December 2015
...Olivier Chazouillères Background: Some patients present with features of both primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) on the one hand and autoimmune hepatitis (AIH) on the other hand, either simultaneously or consecutively. The term ‘overlap syndrome (OS)' is used...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 2–12.
Published Online: 07 December 2015
...Peter Jepsen; Lisbet Grønbæk; Hendrik Vilstrup Background: The variation that occurs in the incidence patterns of autoimmune liver diseases may provide insight into the risk factors causing the diseases. We systematically reviewed studies on the incidence of autoimmune hepatitis (AIH), primary...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 36–46.
Published Online: 07 December 2015
...Rodrigo Liberal; Diego Vergani; Giorgina Mieli-Vergani In paediatrics, there are 2 liver disorders in which liver damage most likely stems from an autoimmune attack: ‘classical' autoimmune hepatitis (AIH) and the AIH/sclerosing cholangitis overlap syndrome (also known as autoimmune sclerosing...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2015) 33 (Suppl. 2): 53–64.
Published Online: 07 December 2015
...Dina G. Tiniakos; John G. Brain; Yvonne A. Bury The diagnosis of autoimmune hepatitis (AIH) is based on a combination of biochemical, immunological and histological features and exclusion of other causes of liver disease. Typical histological features include a chronic hepatitis pattern of injury...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2014) 32 (5): e1–e6.
Published Online: 22 August 2014
... a model of disease for which environmental and genetic influences are highly relevant to why any individual develops disease. The overlapping clinical presentations of primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis further highlight the likelihood for shared pathways...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2014) 32 (5): 502–506.
Published Online: 14 July 2014
...Marcial Sebode; Ansgar W. Lohse In the last two decades, more and more light has been shed on the immunologic pathogenesis of autoimmune liver diseases, notably autoimmune hepatitis (AIH). An immunologic dysbalance with proinflammatory immune responses dominating over hepatic tolerance seems...
Journal Articles
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2012) 30 (Suppl. 1): 2–10.
Published Online: 11 October 2012
...Matthias Hardtke-Wolenski; Richard Taubert; Elmar Jaeckel Autoimmune hepatitis (AIH) is a chronic autoimmune inflammation of the liver usually requiring lifelong immunosuppression. Steroids and azathioprine are the standard therapy, but the therapy is accompanied by strong side effects. Due...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2012) 30 (2): 212–215.
Published Online: 20 June 2012
...Jan Lata Autoimmune hepatitis (AIH) is a generally progressive, chronic liver disease of unknown etiology, relatively uncommon, associated with chronic hepatic inflammation. An environmental agent is hypothesized to trigger an immune-mediated attack directed against liver antigens in genetically...
Journal Articles
Dig Dis (2011) 29 (4): 411–415.
Published Online: 30 August 2011
...Michael P. Manns; Christian P. Strassburg Autoimmune hepatitis (AIH) is a disease of unknown etiology. However, a loss of tolerance against the patient’s own liver is regarded as the main pathogenetic mechanism. Immunosuppressive therapy prolongs survival in patients with severe AIH. Two phases...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2011) 29 (4): 402–410.
Published Online: 30 August 2011
...Matthias Hardtke-Wolenski; Fatih Noyan; Elmar Jaeckel Autoimmune hepatitis (AIH) is a chronic autoimmune inflammation of the liver usually requiring life-long immunosuppression. Steroids and azathioprin are the standard therapy, but the therapy is accompanied by strong side effects. Due to the fact...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2010) 28 (1): 80–85.
Published Online: 07 May 2010
...Urs Christen; Martin Holdener; Edith Hintermann Cytochrome P450 2D6 (CYP2D6) has been identified as the major autoantigen in type 2 autoimmune hepatitis (AIH). However, because of a lack of appropriate animal models, the etiology of AIH is still poorly understood. We generated a mouse model for AIH...
Journal Articles
Subject Area:
Gastroenterology
Dig Dis (2010) 28 (1): 93–98.
Published Online: 07 May 2010
...Christian P. Strassburg First described in 1950, autoimmune hepatitis (AIH) was the first chronic liver disease with a favorable response to drug therapy and a dismal prognosis when left untreated. In the decades since the first treatment studies, the basic strategy of inducing remission...