... acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab Invest 2006;86:166-174. 11. Benz C, Angermüller S, Töx U, Klöters-Plachky P, Riedel HD, Sauer P, Stremmel W, Stiehl A: Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis...

...) is an evolutionarily conserved bicarbonate sensor that regulates apoptosis, barrier function and TNF signaling. Key Messages: The biliary epithelium defends against the toxic bile by bicarbonate secretion and by maintaining a tight barrier. Passive diffusion of weak acid conjugates (e.g. bile salts and other toxins...

... of these agents and corresponding in vivo assessment of mucosal immune responses. Several experimental studies have indicated that one of the main functions of efficacious anti-TNF therapy in IBD is the induction of intestinal cell apoptosis. Fittingly, a corresponding molecular-imaging study using single-photon...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatocellular carcinoma Chemoresistance Sorafenib Signaling pathway MicroRNA Apoptosis Immunity Cancer stem cell Epithelial-mesenchymal transition Hepatocellular carcinoma (HCC...

...Simon Hohenester; Lucas Maillette de Buy Wenniger; Douglas M. Jefferson; Ronald P. Oude Elferink; Ulrich Beuers Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis...

... of ALD [ 16,17 ]. Zinc is known to participate in multiple cellular functions, including metabolism, cell signaling and gene regulation. Zinc deprivation in cell culture studies has been shown to induce apoptosis in diverse cell lines including HepG2 cells [ 18,19,20 ]. Zinc deprivation also potentiates...

...Soichi Kojima; Ting-Fang Kuo; Hideki Tatsukawa; Shigehisa Hirose Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) share many histological similarities, but the molecular mechanisms responsible for hepatic apoptosis remain unclear. We previously reported that transglutaminase...

...Youngmi Jung; Anna Mae Diehl Background: Increased hepatocyte apoptosis distinguishes non-alcoholic steatohepatitis (NASH) from non-alcoholic fatty liver disease (NAFLD). Therefore, we postulated that outcomes of NASH depended upon whether or not hepatic regenerative responses could keep pace...

...Alisan Kahraman; Guido Gerken; Ali Canbay Autoimmune diseases of the liver are chronic inflammatory processes leading to injury of hepatocytes and cholangiocytes. Cell death by apoptosis is a prominent feature in a variety of liver diseases. It is likely that apoptosis is the initial cellular...

... are dominated by interleukin (IL)-13 and TNF-α in ulcerative colitis (UC). IL-13 does stimulate epithelial apoptosis as well as upregulates claudin-2 in UC. Together with an IL-13-dependent restitution arrest, this may explain why ulcer lesions are seen already early in UC but only in advanced stages of CD...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cirrhosis Antifibrotic therapy Hepatic stellate cell Matrix degradation Apoptosis Review Article Dig Dis 2006;24:174...