Gut Microbiome Dysbiosis and Inflammatory Bowel Disease Complement Each Other Available to Purchase

2.

Ananthakrishnan

AN

.

Epidemiology and risk factors for IBD

.

Nat Rev Gastroenterol Hepatol

.

2015

;

12

(

4

):

205

–

17

.

3.

Agrawal

M

,

Spencer

EA

,

Colombel

JF

,

Ungaro

RC

.

Approach to the management of recently diagnosed inflammatory bowel disease patients: a user's guide for adult and pediatric gastroenterologists

.

Gastroenterology

.

2021

;

161

(

1

):

47

–

65

.

4.

Kaplan

GG

,

Windsor

JW

.

The four epidemiological stages in the global evolution of inflammatory bowel disease

.

Nat Rev Gastroenterol Hepatol

.

2021

;

18

(

1

):

56

–

66

.

5.

Davenport

ER

,

Sanders

JG

,

Song

SJ

,

Amato

KR

,

Clark

AG

,

Knight

R

.

The human microbiome in evolution

.

BMC Biol

.

2017

;

15

(

1

):

127

.

6.

Barko

PC

,

McMichael

MA

,

Swanson

KS

,

Williams

DA

.

The gastrointestinal microbiome: a review

.

J Vet Intern Med

.

2018

;

32

(

1

):

9

–

25

.

7.

Bien

J

,

Palagani

V

,

Bozko

P

.

The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease

.

Therap Adv Gastroenterol

.

2013

;

6

(

1

):

53

–

68

.

8.

Zakerska-Banaszak

O

,

Tomczak

H

,

Gabryel

M

,

Baturo

A

,

Wolko

L

,

Michalak

M

, et al.

Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: a pilot study

.

Sci Rep

.

2021

;

11

(

1

):

2166

.

9.

Elzayat

H

,

Malik

T

,

Al-Awadhi

H

,

Taha

M

,

Elghazali

G

,

Al-Marzooq

F

.

Deciphering salivary microbiome signature in Crohn’s disease patients with different factors contributing to dysbiosis

.

Sci Rep

.

2023

;

13

(

1

):

19198

.

10.

Alshehri

D

,

Saadah

O

,

Mosli

M

,

Edris

S

,

Alhindi

R

,

Bahieldin

A

.

Dysbiosis of gut microbiota in inflammatory bowel disease: current therapies and potential for microbiota-modulating therapeutic approaches

.

Bosn J Basic Med Sci

.

2021

;

21

(

3

):

270

–

83

.

11.

Lee

M

,

Chang

EB

.

Inflammatory Bowel Diseases (IBD) and the microbiome-searching the crime scene for clues

.

Gastroenterology

.

2021

;

160

(

2

):

524

–

37

.

12.

Serrano-Gómez

G

,

Mayorga

L

,

Oyarzun

I

,

Roca

J

,

Borruel

N

,

Casellas

F

, et al.

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: a shotgun metagenomic approach

.

Comput Struct Biotechnol J

.

2021

;

19

:

6481

–

9

.

13.

Andoh

A

.

Physiological role of gut microbiota for maintaining human health

.

Digestion

.

2016

;

93

(

3

):

176

–

81

.

14.

Machiels

K

,

Joossens

M

,

Sabino

J

,

De Preter

V

,

Arijs

I

,

Eeckhaut

V

, et al.

A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis

.

Gut

.

2014

;

63

(

8

):

1275

–

83

.

15.

Kang

S

,

Denman

SE

,

Morrison

M

,

Yu

Z

,

Dore

J

,

Leclerc

M

, et al.

Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray

.

Inflamm Bowel Dis

.

2010

;

16

(

12

):

2034

–

42

.

16.

Rajesh

KM

,

Kinra

M

,

Ranadive

N

,

Pawaskar

GM

,

Mudgal

J

,

Raval

R

.

Effect of chronic low-dose treatment with chitooligosaccharides on microbial dysbiosis and inflammation associated chronic ulcerative colitis in Balb/c mice

.

Naunyn Schmiedebergs Arch Pharmacol

.

2024

;

397

(

3

):

1611

–

22

.

17.

Said

HS

,

Suda

W

,

Nakagome

S

,

Chinen

H

,

Oshima

K

,

Kim

S

, et al.

Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers

.

DNA Res

.

2014

;

21

(

1

):

15

–

25

.

18.

Rizzatti

G

,

Lopetuso

LR

,

Gibiino

G

,

Binda

C

,

Gasbarrini

A

.

Proteobacteria: a common factor in human diseases

.

BioMed Res Int

.

2017

;

2017

:

9351507

.

19.

Shin

NR

,

Whon

TW

,

Bae

JW

.

Proteobacteria: microbial signature of dysbiosis in gut microbiota

.

Trends Biotechnol

.

2015

;

33

(

9

):

496

–

503

.

20.

Binda

C

,

Lopetuso

LR

,

Rizzatti

G

,

Gibiino

G

,

Cennamo

V

,

Gasbarrini

A

.

Actinobacteria: a relevant minority for the maintenance of gut homeostasis

.

Dig Liver Dis

.

2018

;

50

(

5

):

421

–

8

.

21.

Qiu

X

,

Zhao

X

,

Cui

X

,

Mao

X

,

Tang

N

,

Jiao

C

, et al.

Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn's disease

.

Therap Adv Gastroenterol

.

2020

;

13

:

1756284820971202

.

22.

Santana

PT

,

Rosas

SLB

,

Ribeiro

BE

,

Marinho

Y

,

de Souza

HSP

.

Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

.

Int J Mol Sci

.

2022

;

23

(

7

):

3464

.

23.

Nishino

K

,

Nishida

A

,

Inoue

R

,

Kawada

Y

,

Ohno

M

,

Sakai

S

, et al.

Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease

.

J Gastroenterol

.

2018

;

53

(

1

):

95

–

106

.

24.

Seksik

P

,

Lepage

P

,

de la Cochetière

MF

,

Bourreille

A

,

Sutren

M

,

Galmiche

JP

, et al.

Search for localized dysbiosis in Crohn’s disease ulcerations by temporal temperature gradient gel electrophoresis of 16S rRNA

.

J Clin Microbiol

.

2005

;

43

(

9

):

4654

–

8

.

25.

Yang

JC

,

Jacobs

JP

,

Hwang

M

,

Sabui

S

,

Liang

F

,

Said

HM

, et al.

Biotin deficiency induces intestinal dysbiosis associated with an inflammatory bowel disease-like phenotype

.

Nutrients

.

2023

;

15

(

2

):

264

.

26.

Lee

JY

,

Cevallos

SA

,

Byndloss

MX

,

Tiffany

CR

,

Olsan

EE

,

Butler

BP

, et al.

High-fat diet and antibiotics cooperatively impair mitochondrial bioenergetics to trigger dysbiosis that exacerbates pre-inflammatory bowel disease

.

Cell Host Microbe

.

2020

;

28

(

2

):

273

–

84.e6

.

27.

Nagao-Kitamoto

H

,

Shreiner

AB

,

Gillilland

MG

3rd,

Kitamoto

S

,

Ishii

C

,

Hirayama

A

, et al.

Functional characterization of inflammatory bowel disease-associated gut dysbiosis in gnotobiotic mice

.

Cell Mol Gastroenterol Hepatol

.

2016

;

2

(

4

):

468

–

81

.

28.

Buttó

LF

,

Schaubeck

M

,

Haller

D

.

Mechanisms of microbe-host interaction in Crohn’s disease: dysbiosis vs. Pathobiont selection

.

Front Immunol

.

2015

;

6

:

555

.

29.

Johansson

ME

,

Gustafsson

JK

,

Holmén-Larsson

J

,

Jabbar

KS

,

Xia

L

,

Xu

H

, et al.

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

.

Gut

.

2014

;

63

(

2

):

281

–

91

.

30.

Ijssennagger

N

,

Belzer

C

,

Hooiveld

GJ

,

Dekker

J

,

van Mil

SW

,

Müller

M

, et al.

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

.

Proc Natl Acad Sci U S A

.

2015

;

112

(

32

):

10038

–

43

.

31.

Barbara

G

,

Barbaro

MR

,

Fuschi

D

,

Palombo

M

,

Falangone

F

,

Cremon

C

, et al.

Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

.

Front Nutr

.

2021

;

8

:

718356

.

32.

Nakanishi

Y

,

Sato

T

,

Ohteki

T

.

Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization

.

Mucosal Immunol

.

2015

;

8

(

1

):

152

–

60

.

33.

Wang

X

,

Quinn

PJ

.

Lipopolysaccharide: biosynthetic pathway and structure modification

.

Prog Lipid Res

.

2010

;

49

(

2

):

97

–

107

.

34.

Papa

A

,

Santini

P

,

De Lucia

SS

,

Maresca

R

,

Porfidia

A

,

Pignatelli

P

, et al.

Gut dysbiosis-related thrombosis in inflammatory bowel disease: potential disease mechanisms and emerging therapeutic strategies

.

Thromb Res

.

2023

;

232

:

77

–

88

.

35.

Sellin

JH

,

Wang

Y

,

Singh

P

,

Umar

S

.

beta-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia

.

Exp Cell Res

.

2009

;

315

(

1

):

97

–

109

.

36.

Sartor

RB

.

Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis

.

Nat Clin Pract Gastroenterol Hepatol

.

2006

;

3

(

7

):

390

–

407

.

37.

Zhu

Y

,

Yang

S

,

Zhao

N

,

Liu

C

,

Zhang

F

,

Guo

Y

, et al.

CXCL8 chemokine in ulcerative colitis

.

Biomed Pharmacother

.

2021

;

138

:

111427

.

38.

González Delgado

S

,

Garza-Veloz

I

,

Trejo-Vazquez

F

,

Martinez-Fierro

ML

.

Interplay between serotonin, immune response, and intestinal dysbiosis in inflammatory bowel disease

.

Int J Mol Sci

.

2022

;

23

(

24

):

15632

.

39.

Martini

E

,

Krug

SM

,

Siegmund

B

,

Neurath

MF

,

Becker

C

.

Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease

.

Cell Mol Gastroenterol Hepatol

.

2017

;

4

(

1

):

33

–

46

.

40.

Means

TK

,

Hayashi

F

,

Smith

KD

,

Aderem

A

,

Luster

AD

.

The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells

.

J Immunol

.

2003

;

170

(

10

):

5165

–

75

.

41.

Cook

L

,

Lisko

DJ

,

Wong

MQ

,

Garcia

RV

,

Himmel

ME

,

Seidman

EG

, et al.

Analysis of flagellin-specific adaptive immunity reveals links to dysbiosis in patients with inflammatory bowel disease

.

Cell Mol Gastroenterol Hepatol

.

2020

;

9

(

3

):

485

–

506

.

42.

Shapiro

JM

,

Cho

JH

,

Sands

BE

,

LeLeiko

NS

.

Bridging the gap between host immune response and intestinal dysbiosis in inflammatory bowel disease: does immunoglobulin A mark the spot

.

Clin Gastroenterol Hepatol

.

2015

;

13

(

5

):

842

–

6

.

43.

Zhou

L

,

Zhang

M

,

Wang

Y

,

Dorfman

RG

,

Liu

H

,

Yu

T

, et al.

Faecalibacterium prausnitzii produces butyrate to maintain Th17/treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1

.

Inflamm Bowel Dis

.

2018

;

24

(

9

):

1926

–

40

.

44.

de Jong

RJ

,

Ohnmacht

C

.

Defining dysbiosis in inflammatory bowel disease

.

Immunity

.

2019

;

50

(

1

):

8

–

10

.

45.

Cong

Y

,

Feng

T

,

Fujihashi

K

,

Schoeb

TR

,

Elson

CO

.

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

.

Proc Natl Acad Sci U S A

.

2009

;

106

(

46

):

19256

–

61

.

46.

Lee

HJ

,

Jeong

JJ

,

Han

MJ

,

Kim

DH

.

Lactobacillus plantarum C29 alleviates TNBS-induced memory impairment in mice

.

J Microbiol Biotechnol

.

2018

;

28

(

1

):

175

–

9

.

47.

Cheng

H

,

Guan

X

,

Chen

D

,

Ma

W

.

The Th17/treg cell balance: a gut microbiota-modulated story

.

Microorganisms

.

2019

;

7

(

12

):

583

.

48.

Hoffmann

TW

,

Pham

HP

,

Bridonneau

C

,

Aubry

C

,

Lamas

B

,

Martin-Gallausiaux

C

, et al.

Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice

.

ISME J

.

2016

;

10

(

2

):

460

–

77

.

49.

Feng

L

,

Zhou

N

,

Li

Z

,

Fu

D

,

Guo

Y

,

Gao

X

, et al.

Co-occurrence of gut microbiota dysbiosis and bile acid metabolism alteration is associated with psychological disorders in Crohn’s disease

.

FASEB J

.

2022

;

36

(

1

):

e22100

.

50.

Dubinsky

V

,

Reshef

L

,

Rabinowitz

K

,

Yadgar

K

,

Godny

L

,

Zonensain

K

, et al.

Dysbiosis in metabolic genes of the gut microbiomes of patients with an ileo-anal pouch resembles that observed in Crohn’s disease

.

mSystems

.

2021

;

6

(

2

):

e00984-20

.

51.

Mizuno

S

,

Ono

K

,

Mikami

Y

,

Naganuma

M

,

Fukuda

T

,

Minami

K

, et al.

5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

.

Intest Res

.

2020

;

18

(

1

):

69

–

78

.

52.

Maldonado-Arriaga

B

,

Sandoval-Jiménez

S

,

Rodríguez-Silverio

J

,

Lizeth Alcaráz-Estrada

S

,

Cortés-Espinosa

T

,

Pérez-Cabeza de Vaca

R

, et al.

Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis

.

MicrobiologyOpen

.

2021

;

10

(

2

):

e1181

.

53.

Boland

K

,

Bedrani

L

,

Turpin

W

,

Kabakchiev

B

,

Stempak

J

,

Borowski

K

, et al.

Persistent diarrhea in patients with Crohn's disease after mucosal healing is associated with lower diversity of the intestinal microbiome and increased dysbiosis

.

Clin Gastroenterol Hepatol

.

2021

;

19

(

2

):

296

–

304.e3

.

54.

Shimizu

Y

,

Nakamura

K

,

Yoshii

A

,

Yokoi

Y

,

Kikuchi

M

,

Shinozaki

R

, et al.

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice

.

Life Sci Alliance

.

2020

;

3

(

6

):

e201900592

.

55.

Gold

SL

,

Cohen-Mekelburg

S

.

An apple a day keeps the doctor away: the effect of a low-fat, high-fiber diet on quality of life, inflammation, and dysbiosis in patients with ulcerative colitis

.

Gastroenterology

.

2022

;

162

(

4

):

1357

–

8

.

56.

Yan

D

,

Ye

S

,

He

Y

,

Wang

S

,

Xiao

Y

,

Xiang

X

, et al.

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

.

Front Immunol

.

2023

;

14

:

1286667

.

57.

Perri

MR

,

Romano

C

,

Marrelli

M

,

Zicarelli

L

,

Toma

CC

,

Basta

D

, et al.

Beneficial role of fruits, their juices, and freeze-dried powders on inflammatory bowel disease and related dysbiosis

.

Plants

.

2021

;

11

(

1

):

4

.

58.

Zhang

Y

,

Liu

W

,

Zhang

D

,

Yang

Y

,

Wang

X

,

Li

L

.

Fermented and germinated processing improved the protective effects of foxtail millet whole grain against dextran sulfate sodium-induced acute ulcerative colitis and gut microbiota dysbiosis in C57bl/6 mice

.

Front Nutr

.

2021

;

8

:

694936

.

59.

Imai

T

,

Inoue

R

,

Kawada

Y

,

Morita

Y

,

Inatomi

O

,

Nishida

A

, et al.

Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease

.

J Gastroenterol

.

2019

;

54

(

2

):

149

–

59

.

60.

Swanson

GR

,

Kochman

N

,

Amin

J

,

Chouhan

V

,

Yim

W

,

Engen

PA

, et al.

Disrupted circadian rest-activity cycles in inflammatory bowel disease are associated with aggressive disease phenotype, subclinical inflammation, and dysbiosis

.

Front Med

.

2021

;

8

:

770491

.

61.

Mc Gettigan

N

,

O’Toole

A

,

Boland

K

.

Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel disease”: a letter to the editor

.

World J Gastroenterol

.

2022

;

28

(

8

):

878

–

80

.

62.

Lunney

PC

,

Leong

RW

.

Review article: ulcerative colitis, smoking and nicotine therapy

.

Aliment Pharmacol Ther

.

2012

;

36

(

11–12

):

997

–

1008

.

63.

Benjamin

JL

,

Hedin

CR

,

Koutsoumpas

A

,

Ng

SC

,

McCarthy

NE

,

Prescott

NJ

, et al.

Smokers with active Crohn’s disease have a clinically relevant dysbiosis of the gastrointestinal microbiota

.

Inflamm Bowel Dis

.

2012

;

18

(

6

):

1092

–

100

.

64.

Liu

TC

,

Gurram

B

,

Baldridge

MT

,

Head

R

,

Lam

V

,

Luo

C

, et al.

Paneth cell defects in Crohn’s disease patients promote dysbiosis

.

JCI insight

.

2016

;

1

(

8

):

e86907

.

65.

VanDussen

KL

,

Liu

TC

,

Li

D

,

Towfic

F

,

Modiano

N

,

Winter

R

, et al.

Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn’s disease

.

Gastroenterology

.

2014

;

146

(

1

):

200

–

9

.

66.

Sharma

U

,

Olson

RK

,

Erhart

FN

,

Zhang

L

,

Meng

J

,

Segura

B

, et al.

Prescription opioids induce gut dysbiosis and exacerbate colitis in a murine model of inflammatory bowel disease

.

J Crohns Colitis

.

2020

;

14

(

6

):

801

–

17

.

67.

Kiecka

A

,

Szczepanik

M

.

Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics

.

Pharmacol Rep

.

2023

;

75

(

4

):

791

–

804

.

68.

Weingarden

AR

,

Vaughn

BP

.

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

.

Gut Microbes

.

2017

;

8

(

3

):

238

–

52

.

69.

Xue

AJ

,

Miao

SJ

,

Sun

H

,

Qiu

XX

,

Wang

SN

,

Wang

L

, et al.

Intestinal dysbiosis in pediatric Crohn’s disease patients with IL10RA mutations

.

World J Gastroenterol

.

2020

;

26

(

22

):

3098

–

109

.

70.

Sokol

H

,

Mahlaoui

N

,

Aguilar

C

,

Bach

P

,

Join-Lambert

O

,

Garraffo

A

, et al.

Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

.

J Allergy Clin Immunol

.

2019

;

143

(

2

):

775

–

8.e6

.

71.

Chen

W

,

Chen

H

,

Fu

S

,

Lin

X

,

Zheng

Z

,

Zhang

J

.

Microbiome characterization and re-design by biologic agents for inflammatory bowel disease insights

.

Bioprocess Biosyst Eng

.

2021

;

44

(

5

):

929

–

39

.

72.

Lee

JWJ

,

Plichta

D

,

Hogstrom

L

,

Borren

NZ

,

Lau

H

,

Gregory

SM

, et al.

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

.

Cell Host Microbe

.

2021

;

29

(

8

):

1294

–

304.e4

.

73.

Bretin

A

,

Lucas

C

,

Larabi

A

,

Dalmasso

G

,

Billard

E

,

Barnich

N

, et al.

AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

.

Sci Rep

.

2018

;

8

(

1

):

12301

.

74.

Zhilu

X

,

Xiangqian

D

,

Keli

Y

,

Caroline

C

,

Jingwan

Z

,

Yu

L

, et al.

Association of Adherent-invasive Escherichia coli with severe Gut Mucosal dysbiosis in Hong Kong Chinese population with Crohn’s disease

.

Gut Microbes

.

2021

;

13

(

1

):

1994833

.

75.

Ni

J

,

Wu

GD

,

Albenberg

L

,

Tomov

VT

.

Gut microbiota and IBD: causation or correlation

.

Nat Rev Gastroenterol Hepatol

.

2017

;

14

(

10

):

573

–

84

.

76.

Lin

S

,

Zhang

X

,

Zhu

X

,

Jiao

J

,

Wu

Y

,

Li

Y

, et al.

Fusobacterium nucleatum aggravates ulcerative colitis through promoting gut microbiota dysbiosis and dysmetabolism

.

J Periodontol

.

2023

;

94

(

3

):

405

–

18

.

77.

Sultan

S

,

El-Mowafy

M

,

Elgaml

A

,

Ahmed

TAE

,

Hassan

H

,

Mottawea

W

.

Metabolic influences of gut microbiota dysbiosis on inflammatory bowel disease

.

Front Physiol

.

2021

;

12

:

715506

.

78.

Hu

Y

,

Chen

Z

,

Xu

C

,

Kan

S

,

Chen

D

.

Disturbances of the gut microbiota and microbiota-derived metabolites in inflammatory bowel disease

.

Nutrients

.

2022

;

14

(

23

):

5140

.

79.

Scheppach

W

.

Effects of short chain fatty acids on gut morphology and function

.

Gut

.

1994

;

35

(

1 Suppl l

):

S35

–

8

.

80.

Lemons

JMS

,

Conrad

M

,

Tanes

C

,

Chen

J

,

Friedman

ES

,

Roggiani

M

, et al.

Enterobacteriaceae growth promotion by intestinal acylcarnitines, a biomarker of dysbiosis in inflammatory bowel disease

.

Cell Mol Gastroenterol Hepatol

.

2024

;

17

(

1

):

131

–

48

.

81.

Stummer

N

,

Feichtinger

RG

,

Weghuber

D

,

Kofler

B

,

Schneider

AM

.

Role of hydrogen sulfide in inflammatory bowel disease

.

Antioxidants

.

2023

;

12

(

8

):

1570

.

82.

Li

Q

,

Wang

C

,

Tang

C

,

He

Q

,

Li

N

,

Li

J

.

Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn’s disease

.

J Clin Gastroenterol

.

2014

;

48

(

6

):

513

–

23

.

83.

Hoarau

G

,

Mukherjee

PK

,

Gower-Rousseau

C

,

Hager

C

,

Chandra

J

,

Retuerto

MA

, et al.

Bacteriome and mycobiome interactions underscore microbial dysbiosis in familial Crohn's disease

.

mBio

.

2016

;

7

(

5

):

e01250-16

.

84.

Yu

M

,

Ding

H

,

Gong

S

,

Luo

Y

,

Lin

H

,

Mu

Y

, et al.

Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis

.

Front Cell Infect Microbiol

.

2023

;

13

:

1140757

.

85.

Armstrong

H

,

Rahbari

M

,

Park

H

,

Sharon

D

,

Thiesen

A

,

Hotte

N

, et al.

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10(-/-) mouse model of inflammatory bowel disease

.

Microbiome

.

2023

;

11

(

1

):

39

.

86.

Kong

C

,

Liu

G

,

Kalady

MF

,

Jin

T

,

Ma

Y

.

Dysbiosis of the stool DNA and RNA virome in Crohn’s disease

.

J Med Virol

.

2023

;

95

(

2

):

e28573

.

87.

Mill

J

,

Lawrance

IC

.

Preventing infective complications in inflammatory bowel disease

.

World J Gastroenterol

.

2014

;

20

(

29

):

9691

–

8

.

88.

Chang

S

,

Murphy

M

,

Malter

L

.

A review of available medical therapies to treat moderate-to-severe inflammatory bowel disease

.

Am J Gastroenterol

.

2024

;

119

(

1

):

55

–

80

.

89.

Danilova

NA

,

Abdulkhakov

SR

,

Grigoryeva

TV

,

Markelova

MI

,

Vasilyev

IY

,

Boulygina

EA

, et al.

Markers of dysbiosis in patients with ulcerative colitis and Crohn’s disease

.

Ter Arkh

.

2019

;

91

(

4

):

17

–

24

.

90.

Buffet-Bataillon

S

,

Landreau

C

,

Siproudhis

L

,

Cattoir

V

,

Bouguen

G

.

Bacterial gut dysbiosis is associated with Crohn's disease symptoms but not with elevated fecal calprotectin

.

Clin Res Hepatol Gastroenterol

.

2021

;

45

(

2

):

101669

.

91.

Rajca

S

,

Grondin

V

,

Louis

E

,

Vernier-Massouille

G

,

Grimaud

JC

,

Bouhnik

Y

, et al.

Alterations in the intestinal microbiome (dysbiosis) as a predictor of relapse after infliximab withdrawal in Crohn’s disease

.

Inflamm Bowel Dis

.

2014

;

20

(

6

):

978

–

86

.

92.

Moayyedi

P

,

Surette

MG

,

Kim

PT

,

Libertucci

J

,

Wolfe

M

,

Onischi

C

, et al.

Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial

.

Gastroenterology

.

2015

;

149

(

1

):

102

–

9.e6

.

93.

Xiang

L

,

Ding

X

,

Li

Q

,

Wu

X

,

Dai

M

,

Long

C

, et al.

Efficacy of faecal microbiota transplantation in Crohn's disease: a new target treatment

.

Microb Biotechnol

.

2020

;

13

(

3

):

760

–

9

.

94.

Haifer

C

,

Paramsothy

S

,

Kaakoush

NO

,

Saikal

A

,

Ghaly

S

,

Yang

T

, et al.

Lyophilised Oral faecal microbiota Transplantation for Ulcerative Colitis (LOTUS): a randomised, double-blind, placebo-controlled trial

.

Lancet Gastroenterol Hepatol

.

2022

;

7

(

2

):

141

–

51

.

95.

Cao

F

,

Jin

L

,

Gao

Y

,

Ding

Y

,

Wen

H

,

Qian

Z

, et al.

Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis

.

Nat Nanotechnol

.

2023

;

18

(

6

):

617

–

27

.

96.

Long

D

,

Merlin

D

.

Micro- and nanotechnological delivery platforms for treatment of dysbiosis-related inflammatory bowel disease

.

Nanomedicine

.

2021

;

16

(

20

):

1741

–

5

.

97.

Fritsch

J

,

Garces

L

,

Quintero

MA

,

Pignac-Kobinger

J

,

Santander

AM

,

Fernández

I

, et al.

Low-fat, high-fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis

.

Clin Gastroenterol Hepatol

.

2021

;

19

(

6

):

1189

–

99.e30

.

98.

Li

Q

,

Li

L

,

Li

Q

,

Wang

J

,

Nie

S

,

Xie

M

.

Influence of natural polysaccharides on intestinal microbiota in inflammatory bowel diseases: an overview

.

Foods

.

2022

;

11

(

8

):

1084

.

99.

Li

L

,

Peng

P

,

Ding

N

,

Jia

W

,

Huang

C

,

Tang

Y

.

Oxidative stress, inflammation, gut dysbiosis: what can polyphenols do in inflammatory bowel disease

.

Antioxidants

.

2023

;

12

(

4

):

967

.