Introduction: We investigated the hemostatic effect and safety of a hemostatic peptide solution for the treatment of gastrointestinal bleeding requiring emergency endoscopy. Methods: We retrospectively examined the patient backgrounds, hemostatic results, and procedural safety in patients who were treated with a hemostatic peptide solution for hemostasis during emergency endoscopies for gastrointestinal bleeding. All hemostatic procedures were performed by nonexpert physicians with less than 10 years of endoscopic experience. All of the cases were treated at a single institution over the months from January 2022 to January 2023. Results: Twenty-six consecutive patients (17 males and 9 females) with a median age of 74 (45–95) years were included. Their conditions requiring emergency endoscopy were melena in 8 patients, hematochezia in 2, hematemesis in 8, anemia in 6, and bleeding during esophagogastroduodenoscopy in 2. The sites of bleeding were the esophagus in 3 patients, the stomach in 17, the duodenum in 3, the small intestine in 2, and the colon in 1. Hemostasis was obtained with another hemostasis device used in conjunction with the hemostatic peptide solution in 13 cases and with the hemostatic peptide solution alone in 13 cases. The hemostasis success rate was 100%, with no complications. Rebleeding occurred within 1 week in 4 cases. Conclusion: Hemostasis with the hemostatic peptide solution was safe and provided a temporary high hemostatic effect in emergency gastrointestinal endoscopy.

1.
Mullady
DK
,
Wang
AY
,
Waschke
KA
.
AGA clinical practice update on endoscopic therapies for non variceal upper gastrointestinal bleeding: expert review
.
Gastroenterology
.
2020
;
159
(
3
):
1120
8
.
2.
Baracat
F
,
Moura
E
,
Bernardo
W
,
Pu
LZ
,
Mendonça
E
,
Moura
D
.
Endoscopic hemostasis for peptic ulcer bleeding: systematic review and meta-analyses of randomized controlled trials
.
Surg Endosc
.
2016
;
30
(
6
):
2155
68
.
3.
Tang
D
,
Yuan
F
,
Ma
X
,
Qu
H
,
Li
Y
,
Zhang
W
.
Incidence rates, risk factors, and outcomes of aspiration pneumonia after gastric endoscopic submucosal dissection: a systematic review and meta-analysis
.
J Gastroenterol Hepatol
.
2021
;
36
(
6
):
1457
69
.
4.
Laine
L
,
Jensen
DM
.
Management of patients with ulcer bleeding
.
Am J Gastroenterol
.
2012
;
107
(
3
):
345
60
; quiz 361.
5.
Kamal
F
,
Khan
MA
,
Tariq
R
,
Ismail
MK
,
Tombazzi
C
,
Howden
CW
.
Systematic review and meta-analysis: monopolar hemostatic forceps with soft coagulation in the treatment of peptic ulcer bleeding
.
Eur J Gastroenterol Hepatol
.
2020
;
32
(
6
):
678
85
.
6.
Laine
L
,
Barkun
AN
,
Saltzman
JR
,
Martel
M
,
Leontiadis
GI
.
ACG clinical guideline: upper gastrointestinal and ulcer bleeding
.
Am J Gastroenterol
.
2021
;
116
(
5
):
899
917
.
7.
Kim
JW
,
Jang
JY
,
Lee
CK
,
Shim
JJ
,
Chang
YW
.
Comparison of hemostatic forceps with soft coagulation versus argon plasma coagulation for bleeding peptic ulcer – a randomized trial
.
Endoscopy
.
2015
;
47
(
8
):
680
7
.
8.
Zhang
S
,
Holmes
T
,
Lockshin
C
,
Rich
A
.
Spontaneous assembly of a self- complementary oligopeptide to form a stable macroscopic membrane
.
Proc Natl Acad Sci
.
1993
;
90
(
8
):
3334
8
.
9.
Masuhara
H
,
Fujii
T
,
Watanabe
Y
,
Koyama
N
,
Tokuhiro
K
.
Novel infectious agent-free hemostatic material (TDM-621) in cardiovascular surgery
.
Ann Thorac Cardiovasc Surg
.
2012
;
18
(
5
):
444
51
.
10.
Uraoka
T
,
Uedo
N
,
Oyama
T
,
Saito
Y
,
Yahagi
N
,
Fujimoto
A
.
Efficacy and safety of a novel hemostatic peptide solution during endoscopic submucosal dissection: a multicenter randomized controlled trial
.
Am J Gastroenterol
.
2023
;
118
(
2
):
276
83
.
11.
de Nucci
G
,
Reati
R
,
Arena
I
,
Bezzio
C
,
Devani
M
,
Corte
CD
.
Efficacy of a novel self-assembling peptide hemostatic gel as rescue therapy for refractory acute gastrointestinal bleeding
.
Endoscopy
.
2020
;
52
(
9
):
773
9
.
12.
Branchi
F
,
Klingenberg-Noftz
R
,
Friedrich
K
,
Bürgel
N
,
Daum
S
,
Buchkremer
J
.
PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study
.
Surg Endosc
.
2022
;
36
(
5
):
2954
61
.
13.
Murakami
T
,
Kamba
E
,
Haga
K
,
Akazawa
Y
,
Ueyama
H
,
Shibuya
T
.
Emergency endoscopic hemostasis for gastrointestinal bleeding using a self-assembling peptide: a case series
.
Med Kaunas
.
2023
;
59
(
5
):
931
.
14.
Forrest
JA
,
Finlayson
ND
,
Shearman
DJ
.
Endoscopy in gastrointestinal bleeding
.
Lancet
.
1974
;
2
(
7877
):
394
7
.
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