Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis Available to Purchase

2.

Ramos

GP

,

Papadakis

KA

.

Mechanisms of disease: inflammatory bowel diseases

.

Mayo Clin Proc

.

2019

;

94

(

1

):

155

–

65

.

3.

Biasi

F

,

Leonarduzzi

G

,

Oteiza

PI

,

Poli

G

.

Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets

.

Antioxid Redox Signal

.

2013

;

19

(

14

):

1711

–

47

.

4.

Lev-Tzion

R

,

Turner

D

.

Is pediatric IBD treatment different than in adults

.

Minerva Gastroenterol Dietol

.

2012

;

58

(

2

):

137

–

50

.

5.

Kahn

SA

.

The transition from pediatric to adult inflammatory bowel disease care

.

Gastroenterol Hepatol

.

2016

;

12

(

6

):

403

–

6

.

6.

Weigert

J

,

Obermeier

F

,

Neumeier

M

,

Wanninger

J

,

Filarsky

M

,

Bauer

S

et al.

Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn’s disease

.

Inflamm Bowel Dis

.

2010

;

16

(

4

):

630

–

7

.

7.

Ouchi

N

,

Parker

JL

,

Lugus

JJ

,

Walsh

K

.

Adipokines in inflammation and metabolic disease

.

Nat Rev Immunol

.

2011

;

11

(

2

):

85

–

97

.

8.

Hosogai

N

,

Fukuhara

A

,

Oshima

K

,

Miyata

Y

,

Tanaka

S

,

Segawa

K

et al.

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

.

Diabetes

.

2007

;

56

(

4

):

901

–

11

.

9.

Olszanecka-Glinianowicz

M

,

Handzlik-Orlik

G

,

Orlik

B

,

Chudek

J

.

Adipokines in the pathogenesis of idiopathic inflammatory bowel disease

.

Endokrynol Pol

.

2013

;

64

(

3

):

226

–

31

.

10.

Karmiris

K

,

Koutroubakis

IE

,

Xidakis

C

,

Polychronaki

M

,

Voudouri

T

,

Kouroumalis

EA

.

Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease

.

Inflamm Bowel Dis

.

2006

;

12

(

2

):

100

–

5

.

11.

Trujillo

ME

,

Scherer

PE

.

Adiponectin: journey from an adipocyte secretory protein to biomarker of the metabolic syndrome

.

J Intern Med

.

2005

;

257

(

2

):

167

–

75

.

12.

Devaraj

S

,

Torok

N

,

Dasu

MR

,

Samols

D

,

Jialal

I

.

Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop

.

Arterioscler Thromb Vasc Biol

.

2008

;

28

(

7

):

1368

–

74

.

13.

Bril

F

,

Cusi

K

.

Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis

.

Ann Intern Med

.

2017

;

166

(

3

):

230

.

14.

Yamamoto

K

,

Kiyohara

T

,

Murayama

Y

,

Kihara

S

,

Okamoto

Y

,

Funahashi

T

et al.

Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn’s disease

.

Gut

.

2005

;

54

(

6

):

789

–

96

.

15.

Moher

D

,

Liberati

A

,

Tetzlaff

J

,

Altman

DG

PRISMA Group

.

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

.

PLoS Med

.

2009

;

6

(

7

):

e1000097

.

16.

Team RCR

A language and environment for statistical computing

.

2013

.

17.

Ponemone

V

,

Keshavarzian

A

,

Brand

MI

,

Saclarides

T

,

Abcarian

H

,

Cabay

RJ

et al.

Apoptosis and inflammation: role of adipokines in inflammatory bowel disease

.

Clin Transl Gastroenterol

.

2010

;

1

(

10

):

e1

.

18.

Paul

G

,

Schaffler

A

,

Neumeier

M

,

Fürst

A

,

Bataillle

F

,

Buechler

C

et al.

Profiling adipocytokine secretion from creeping fat in Crohn’s disease

.

Inflamm Bowel Dis

.

2006

;

12

(

6

):

471

–

7

.

19.

Feng

Y

,

Li

Y

,

Mei

S

,

Zhang

L

,

Gong

J

,

Gu

L

et al.

Exclusive enteral nutrition ameliorates mesenteric adipose tissue alterations in patients with active Crohn’s disease

.

Clin Nutr

.

2014

;

33

(

5

):

850

–

8

.

20.

He

X

,

Zhang

QQ

,

Wang

Z

,

Wang

WZ

,

Wang

LH

.

Chinese medicine enema for treatment of patients with mild to moderate ulcerative colitis: therapeutic effect and regulatory effect on adiponectin

.

World Chin J Dig

.

2015

;

23

(

17

):

2834

–

8

.

21.

De Salvo

C

,

Dogliotti

G

,

Spina

L

,

Galliera

E

,

Ricci

C

,

Munizio

N

et al.

56 effect of infliximab infusions on serum adipocytokines levels in inflammatory bowel diseases

.

Dig Liver Dis

.

2010

42

S123

.

22.

Frivolt

K

,

Schwerd

T

,

Schatz

SB

et al.

Serum adipokine levels during infliximab therapy in pediatric crohn’s disease

.

United Eur Gastroenterol J

.

2013

1

A530

.

23.

Scoville

EA

,

Brown

CT

,

Allaman

MM

,

Motley

A

,

Koyama

T

,

Horst

SN

et al.

Sa1849 differences in serum adipokines between crohn’s disease and ulcerative colitis patients indicate that they may represent non-invasive biomarkers

.

Gastroenterology

.

2016

150

4

S380

.

24.

Thangarajah

D

,

Chapell

K

,

Mandalia

S

,

Frost

G

,

Fell

J

.

Abdominal obesity in Paediatric Crohn’s disease is associated with adipokine dysregulation

.

Journal of Crohn’s and colitis

City

Oxford Univ Press Great Clarendon

St, Oxford OX2 6DP, ENGLAND:

2016

. p.

S355

.

25.

Ortega Moreno

L

,

Sanz-Garcia

A

,

Fernandez de la Fuente

MJ

,

Arroyo Solera

R

,

Fernández-Tomé

S

,

Marin

AC

et al.

Serum adipokines as non-invasive biomarkers in Crohn’s disease

.

Sci Rep

.

2020

;

10

(

1

):

18027

.

26.

Pervanidou

P

,

Panagiotou

I

,

Margonis

D

et al.

Decreased leptin concentrations in newly diagnosed children with inflammatory bowel disease

.

Eur J Clin Invest City

Main St, Malden 02148, MA USA

Wiley-Blackwell Commerce Place

.

2011

350

. p.

11

.

27.

Palatka

K

,

Vereb

Z

,

Davida

L

,

Koncsos

P

,

Seres

I

,

Paragh

G

.

Circulating adipokynes and Paraoxonase-1 activity in overweight Crohn’s disease patients

.

Journal of crohns and colitis

City, England

Oxford Univ Press Great Clarendon St, Oxford OX2 6DP

.

2015

. p.

S114

.

28.

Kurowski

JA

,

Gupta

R

,

Barbur

I

et al.

Serum adipokines and increased abdominal visceral adipose tissue at diagnosis predict need for biologic therapy in pediatric inflammatory bowel disease: pediatric GI award: 1043

.

Am J Gastroenterol

.

2018

113

S598

99

.

29.

He

X

,

Wang

W

,

Zhao

C

,

Sun

J

,

Wang

L

.

Significance of expression of adiponectin in patients with ulcerative colitis

.

World Chin J Dig

.

2015

;

23

(

12

):

1999

–

2002

.

30.

Zekri

AR

,

Bakr

YM

,

Ezzat

MM

,

Zakaria

MS

,

Elbaz

TM

.

Circulating levels of adipocytokines as potential biomarkers for early detection of colorectal carcinoma in Egyptian patients

.

Asian Pac J Cancer Prev

.

2015

;

16

:

6923

–

8

.

31.

Waluga

M

,

Hartleb

M

,

Boryczka

G

,

Kukla

M

,

Zwirska-Korczala

K

.

Serum adipokines in inflammatory bowel disease

.

World J Gastroenterol

.

2014

;

20

(

22

):

6912

–

7

.

32.

Vihinen

MK

,

Kolho

KL

,

Janne

OA

,

Andersson

S

,

Raivio

T

.

Circulating adiponectin as a marker for glucocorticoid-related side effects in children and adolescents with inflammatory bowel disease

.

J Pediatr Gastroenterol Nutr

.

2009

;

48

(

4

):

504

–

6

.

33.

Valentini

L

,

Wirth

EK

,

Schweizer

U

,

Hengstermann

S

,

Schaper

L

,

Koernicke

T

et al.

Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease

.

Nutrition

.

2009

;

25

(

2

):

172

–

81

.

34.

Theocharidou

E

,

Balaska

A

,

Vogiatzis

K

,

Tellis

CC

,

Gossios

TD

,

Athyros

VG

et al.

Hypertrophic mesenteric adipose tissue may play a role in atherogenesis in inflammatory bowel diseases

.

Inflamm Bowel Dis

.

2016

;

22

(

9

):

2206

–

12

.

35.

Sobolewska-Włodarczyk

A

,

Włodarczyk

M

,

Zielińska

A

,

Siwiński

P

,

Wiśniewska-Jarosińska

M

,

Gąsiorowska

A

et al.

Circadian rhythm abnormalities in patients with inflammatory bowel disease: association with adipokine profile

.

Scand J Gastroenterol

.

2020

;

55

(

3

):

294

–

300

.

36.

Rodrigues

VS

,

Milanski

M

,

Fagundes

JJ

,

Torsoni

AS

,

Ayrizono

MLS

,

Nunez

CEC

et al.

Serum levels and mesenteric fat tissue expression of adiponectin and leptin in patients with Crohn’s disease

.

Clin Exp Immunol

.

2012

;

170

(

3

):

358

–

64

.

37.

Mohamadinarab

M

,

Ahmadi

R

,

Gholamrezayi

A

,

Rahvar

F

,

Naghdalipour

M

,

Setayesh

L

et al.

Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance

.

IUBMB Life

.

2020

;

72

(

8

):

1698

–

704

.

38.

Mankowska-Wierzbicka

D

,

Karczewski

J

,

Swora-Cwynar

E

,

Dobrowolska

A

,

Stelmach-Mardas

M

.

The clinical importance of 21-day combined parenteral and enteral nutrition in active inflammatory bowel disease patients

.

Nutrients

.

2019

;

11

(

9

):

2246

.

39.

Kim

SH

,

Jang

SH

,

Kim

JW

,

Kim

BG

,

Lee

KL

,

Kim

YS

et al.

Serum adipocytokine levels as surrogate markers for disease activity of crohn’s disease

.

Am J Med Sci

.

2017

;

353

(

5

):

439

–

44

.

40.

Karmiris

K

,

Koutroubakis

IE

,

Xidakis

C

,

Polychronaki

M

,

Kouroumalis

EA

.

The effect of infliximab on circulating levels of leptin, adiponectin and resistin in patients with inflammatory bowel disease

.

Eur J Gastroenterol Hepatol

.

2007

;

19

(

9

):

789

–

94

.

41.

Kahraman

R

,

Calhan

T

,

Sahin

A

,

Ozdil

K

,

Caliskan

Z

,

Bireller

ES

et al.

Are adipocytokines inflammatory or metabolic mediators in patients with inflammatory bowel disease

.

Ther Clin Risk Manag

.

2017

;

13

:

1295

–

301

.

42.

Gholamrezayi

A

,

Mohamadinarab

M

,

Rahbarinejad

P

,

Fallah

S

,

Barez

SR

,

Setayesh

L

et al.

Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines

.

Lipids Health Dis

.

2020

;

19

(

1

):

230

.

43.

Frivolt

K

,

Schwerd

T

,

Schatz

SB

,

Freudenberg

F

,

Prell

C

,

Werkstetter

KJ

et al.

Hyperadiponectinemia during infliximab induction therapy in pediatric crohn disease

.

J Pediatr Gastroenterol Nutr

.

2018

;

66

(

6

):

915

–

9

.

44.

Chouliaras

G

,

Panayotou

I

,

Margoni

D

,

Mantzou

E

,

Pervanidou

P

,

Manios

Y

et al.

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis

.

Pediatr Res

.

2013

;

74

(

4

):

420

–

6

.

45.

Büning

C

,

von Kraft

C

,

Hermsdorf

M

,

Gentz

E

,

Wirth

EK

,

Valentini

L

et al.

Visceral adipose tissue in patients with Crohn’s disease correlates with disease activity, inflammatory markers, and outcome

.

Inflamm Bowel Dis

.

2015

;

21

(

11

):

2590

–

7

.

46.

Zielińska

A

,

Siwiński

P

,

Sobolewska-Włodarczyk

A

,

Wiśniewska-Jarosińska

M

,

Fichna

J

,

Włodarczyk

M

.

The role of adipose tissue in the pathogenesis of Crohn’s disease

.

Pharmacol Rep

.

2019

;

71

(

1

):

105

–

11

.

47.

Trayhurn

P

,

Wood

IS

.

Adipokines: inflammation and the pleiotropic role of white adipose tissue

.

Br J Nutr

.

2004

;

92

(

3

):

347

–

55

.

48.

Bilski

J

,

Mazur-Bialy

A

,

Wojcik

D

,

Surmiak

M

,

Magierowski

M

,

Sliwowski

Z

et al.

Role of obesity, mesenteric adipose tissue, and adipokines in inflammatory bowel diseases

.

Biomolecules

.

2019 Nov 26

9

12

780

.

49.

Ortega Moreno

L

,

Lamacchia

O

,

Salvemini

L

,

De Bonis

C

,

De Cosmo

S

,

Cignarelli

M

et al.

The paradoxical association of adiponectin with mortality rate in patients with type 2 diabetes: evidence of synergism with kidney function

.

Atherosclerosis

.

2016

;

245

:

222

–

7

.

50.

Ortega Moreno

L

,

Copetti

M

,

Fontana

A

,

De Bonis

C

,

Salvemini

L

,

Trischitta

V

et al.

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

.

Cardiovasc Diabetol

.

2016

;

15

:

17

.

51.

Zietek

T

,

Rath

E

.

Inflammation meets metabolic disease: gut feeling mediated by GLP-1

.

Front Immunol

.

2016

;

7

:

154

.

52.

Yorulmaz

E

,

Adali

G

,

Yorulmaz

H

,

Ulasoglu

C

,

Tasan

G

,

Tuncer

I

.

Metabolic syndrome frequency in inflammatory bowel diseases

.

Saudi J Gastroenterol

.

2011

;

17

(

6

):

376

–

82

.

53.

Kredel

LI

,

Batra

A

,

Stroh

T

,

Kühl

AA

,

Zeitz

M

,

Erben

U

et al.

Adipokines from local fat cells shape the macrophage compartment of the creeping fat in Crohn’s disease

.

Gut

.

2013

;

62

(

6

):

852

–

62

.

54.

Kredel

L

,

Batra

A

,

Siegmund

B

.

Role of fat and adipokines in intestinal inflammation

.

Curr Opin Gastroenterol

.

2014

;

30

(

6

):

559

–

65

.

55.

Swarbrick

MM

,

Havel

PJ

.

Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans

.

Metab Syndr Relat Disord

.

2008

;

6

(

2

):

87

–

102

.

56.

Liu

Z

,

Liang

S

,

Que

S

,

Zhou

L

,

Zheng

S

,

Mardinoglu

A

.

Meta-analysis of adiponectin as a biomarker for the detection of metabolic syndrome

.

Front Physiol

.

2018

;

9

:

1238

.

57.

Gariballa

S

,

Alkaabi

J

,

Yasin

J

,

Al Essa

A

.

Total adiponectin in overweight and obese subjects and its response to visceral fat loss

.

BMC Endocr Disord

.

2019

;

19

(

1

):

55

.

58.

Wang

Y

,

Meng

RW

,

Kunutsor

SK

,

Chowdhury

R

,

Yuan

JM

,

Koh

WP

et al.

Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis

.

Sci Rep

.

2018

;

8

(

1

):

406

.

59.

Bryant

RV

,

Schultz

CG

,

Ooi

S

,

Goess

C

,

Costello

SP

,

Vincent

AD

et al.

Obesity in inflammatory bowel disease: gains in adiposity despite high prevalence of myopenia and osteopenia

.

Nutrients

.

2018

;

10

(

9

):

1192

.

60.

Kadowaki

T

,

Yamauchi

T

.

Adiponectin and adiponectin receptors

.

Endocr Rev

.

2005

;

26

(

3

):

439

–

51

.

61.

Vegiopoulos

A

,

Herzig

S

.

Glucocorticoids, metabolism and metabolic diseases

.

Mol Cell Endocrinol

.

2007

275

1–2

43

61

.

62.

Ouchi

N

,

Walsh

K

.

Adiponectin as an anti-inflammatory factor

.

Clin Chim Acta

.

2007

380

1–2

24

30

.

63.

Sukumaran

S

,

Dubois

DC

,

Jusko

WJ

,

Almon

RR

.

Glucocorticoid effects on adiponectin expression

.

Vitam Horm

.

2012

;

90

:

163

–

86

.

64.

Fallo

F

,

Scarda

A

,

Sonino

N

,

Paoletta

A

,

Boscaro

M

,

Pagano

C

et al.

Effect of glucocorticoids on adiponectin: a study in healthy subjects and in Cushing’s syndrome

.

Eur J Endocrinol

.

2004

;

150

(

3

):

339

–

44

.

65.

Kreiner

F

,

Galbo

H

.

Insulin sensitivity and related cytokines, chemokines, and adipokines in polymyalgia rheumatica

.

Scand J Rheumatol

.

2010

;

39

(

5

):

402

–

8

.

66.

Cimmino

MA

,

Andraghetti

G

,

Briatore

L

,

Salani

B

,

Parodi

M

,

Cutolo

M

et al.

Changes in adiponectin and leptin concentrations during glucocorticoid treatment: a pilot study in patients with polymyalgia rheumatica

.

Ann N Y Acad Sci

.

2010

;

1193

:

160

–

3

.

67.

Karmiris

K

,

Koutroubakis

IE

,

Kouroumalis

EA

.

Leptin, adiponectin, resistin, and ghrelin: implications for inflammatory bowel disease

.

Mol Nutr Food Res

.

2008

;

52

(

8

):

855

–

66

.

68.

Goto

M

,

Goto

A

,

Morita

A

,

Deura

K

,

Sasaki

S

,

Aiba

N

et al.

Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes

.

Obesity

.

2014

;

22

(

2

):

401

–

7

.

69.

Choi

HM

,

Doss

HM

,

Kim

KS

.

Multifaceted physiological roles of adiponectin in inflammation and diseases

.

Int J Mol Sci

.

2020

;

21

(

4

):

1219

.

70.

Song

H

,

Chan

J

,

Rovin

BH

.

Induction of chemokine expression by adiponectin in vitro is isoform dependent

.

Transl Res

.

2009

;

154

(

1

):

18

–

26

.

71.

Neumeier

M

,

Weigert

J

,

Schaffler

A

,

Wehrwein

G

,

Müller-Ladner

U

,

Schölmerich

J

et al.

Different effects of adiponectin isoforms in human monocytic cells

.

J Leukoc Biol

.

2006

;

79

(

4

):

803

–

8

.

72.

Schober

F

,

Neumeier

M

,

Weigert

J

,

Wurm

S

,

Wanninger

J

,

Schäffler

A

et al.

Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release

.

Biochem Biophys Res Commun

.

2007

;

361

(

4

):

968

–

73

.

73.

Punthakee

Z

,

Delvin

EE

,

O’Loughlin

J

,

Paradis

G

,

Levy

E

,

Platt

RW

et al.

Adiponectin, adiposity, and insulin resistance in children and adolescents

.

J Clin Endocrinol Metab

.

2006

;

91

(

6

):

2119

–

25

.

74.

Ohman-Hanson

RA

,

Cree-Green

M

,

Kelsey

MM

,

Bessesen

DH

,

Sharp

TA

,

Pyle

L

et al.

Ethnic and sex differences in adiponectin: from childhood to adulthood

.

J Clin Endocrinol Metab

.

2016

;

101

(

12

):

4808

–

15

.

75.

Karaskova

E

,

Kubickova

V

,

Velganova-Veghova

M

,

Geryk

M

,

Foltenova

H

,

Karasek

D

.

Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease

.

Physiol Res

.

2022

;

71

(

2

):

275

–

84

.

76.

Symonds

ME

,

Aldiss

P

,

Dellschaft

N

,

Law

J

,

Fainberg

HP

,

Pope

M

et al.

Brown adipose tissue development and function and its impact on reproduction

.

J Endocrinol

.

2018

238

1

R53

62

.