The gastric barrier could be considered an active tissue involved in many synthetic and metabolic functions, as the immunological defense, by activating mucosal immune system. Barrier integrity results from a balance between protective and aggressive endogenous factors and from their interaction with exogenous factors (steroidal or nonsteroidal anti-inflammatory drugs, dietary nitrates, nitrites and/or NaCl, stress, Helicobacter pylori infection, food allergens and contaminants, metals, chemicals, radiation, smoking and alcohol intake). Nutrients represent the most important exogenous factors affecting gastric barrier because of the impact on people's everyday life. We report evidence from the literature about nutrients affecting gastric barrier and we investigate the possible effect that nutrients can play to determining or maintaining a gastric barrier dysfunction.

Keywords:
Gastric barrier, Diet, Gastric acid, Defense mechanism, Mucosal permeability
1.
Shen L: Functional morphology of the gastrointestinal tract. Curr Top Microbiol Immunol 2009;337:1-35.
2.
Coruzzi G: Overview of gastrointestinal toxicology. Curr Protoc Toxicol 2010;43:21.1.1-21.1.6.
3.
Dy RM, Lof J, DiBaise JK, Quigley EM: Evaluation of effects of ethyl alcohol and bismuth subsalicylate on gastric mucosal barrier in man. Dig Dis Sci 1999;44:286-289.
4.
Ross IN, Bahari HM, Turnberg LA: The pH gradient across mucus adherent to rat fundic mucosa in vivo and the effect of potential damaging agents. Gastroenterology 1981;81:713-718.
5.
Tulassay Z, Herszenyi L: Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol 2010;24:99-108.
6.
Komori M, Tsuji S, Sun WH, Tsujii M, Kawai N, Yasumaru M, Kakiuchi Y, Kimura A, Sasaki Y, Higashiyama S, Kawano S, Hori M: Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Am J Physiol Gastrointest Liver Physiol 2002;283:G1368-G1378.
7.
Tarnawski AS, Ahluwalia A, Jones MK: The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 2012;19:4-15.
8.
Guth PH: Current concepts in gastric microcirculatory pathophysiology. Yale J Biol Med 1992;65:677-688.
9.
Kawano S, Tsuji S: Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000;15(suppl):D1-D6.
10.
deFoneska A, Kaunitz JD: Gastroduodenal mucosal defense. Curr Opin Gastroenterol 2010;26:604-610.
11.
Wu S, Wu X, Zhu W, Cai WJ, Schaper J, Schaper W: Immunohistochemical study of the growth factors, aFGF, bFGF, PDGF-AB, VEGF-A and its receptor (Flk-1) during arteriogenesis. Mol Cell Biochem 2010;343:223-229.
12.
Bujanda L: The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 2000;95:3374-3382.
13.
McCullough AJ, O'Connor JF: Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 1998;93:2022-2036.
14.
Achord JL: Review of alcoholic hepatitis, and its treatment. Am J Gastroenterol 1993;88:1822-1831.
15.
Schenker S, Montalvo R: Alcohol and the pancreas. Recent Dev Alcohol 1998;14:41-65.
16.
Bode C, Bode JC: Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 2003;17:575-592.
17.
Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS: High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med 1990;322:95-99.
18.
Tramacere I, Negri E, Pelucchi C, Bagnardi V, Rota M, Scotti L, Islami F, Corrao G, La Vecchia C, Boffetta P: A meta-analysis on alcohol drinking and gastric cancer risk. Ann Oncol 2012;23:28-36.
19.
Zima T: Ethanol metabolism and pathobiochemistry of organ damage - 1992. III. Mechanisms of damage to the gastrointestinal tract and the liver by ethanol (in Czech). Sb Lek 1993;94:295-302.
20.
Halsted CH, Robles EA, Mezey E: Distribution of ethanol in the human gastrointestinal tract. Am J Clin Nutr 1973;26:831-834.
21.
Iber FL: Alcohol and the gastrointestinal tract. Gastroenterology 1971;61:120-123.
22.
Laniewska-Dunaj M, Jelski W, Szmitkowski M: The effect of ethanol on the stomach (in Polish). Pol Merkur Lekarski 2012;32:194-197.
23.
Abdulnour-Nakhoul S, Bor S, Imeryuz N, Orlando RC: Mechanisms of basolateral Na+ transport in rabbit esophageal epithelial cells. Am J Physiol 1999;276:G507-G517.
24.
Julkunen RJ, Di Padova C, Lieber CS: First pass metabolism of ethanol - a gastrointestinal barrier against the systemic toxicity of ethanol. Life Sci 1985;37:567-573.
25.
Davenport HW: Ethanol damage to canine oxyntic glandular mucosa. Proc Soc Exp Biol Med 1967;126:657-662.
26.
Davenport HW, Warner HA, Code CF: Functional significance of gastric mucosal barrier to sodium. Gastroenterology 1964;47:142-152.
27.
Shanbour LL, Miller J, Chowdhury TK: Effects of alcohol on active transport in the rat stomach. Am J Dig Dis 1973;18:311-316.
28.
Chari S, Teyssen S, Singer MV: Alcohol and gastric acid secretion in humans. Gut 1993;34:843-847.
29.
Lenz HJ, Ferrari-Taylor J, Isenberg JI: Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology 1983;85:1082-1087.
30.
Hajnal F, Flores MC, Radley S, Valenzuela JE: Effect of alcohol and alcoholic beverages on meal-stimulated pancreatic secretion in humans. Gastroenterology 1990;98:191-196.
31.
Bor S, Bor-Caymaz C, Tobey NA, Abdulnour-Nakhoul S, Orlando RC: Esophageal exposure to ethanol increases risk of acid damage in rabbit esophagus. Dig Dis Sci 1999;44:290-300.
32.
Knoll MR, Kölbel CB, Teyssen S, Singer MV: Action of pure ethanol and some alcoholic beverages on the gastric mucosa in healthy humans: a descriptive endoscopic study. Endoscopy 1998;30:293-301.
33.
Dinoso VP, Chey WY, Siplet H, Lorber SH: Effects of ethanol on the gastric mucosa of the Heidenhain pouch of dogs. Am J Dig Dis 1970;15:809-817.
34.
Robert A: Cytoprotection by prostaglandins. Gastroenterology 1979;77:761-767.
35.
Dziadus-Sokolowska A, Orlef A, Bilski R, Mroczka J: The effect of ethanol-caffeine interaction on the gastric mucosal barrier. Pol J Pharmacol Pharm 1989;41:253-258.
36.
Gotteland M, Cruchet S, Frau V, Wegner ME, Lopez R, Herrera T, Sanchez A, Urrutia C, Brunser O: Effect of acute cigarette smoking, alone or with alcohol, on gastric barrier function in healthy volunteers. Dig Liver Dis 2002;34:702-706.
37.
Gotteland M, Cruchet S, Verbeke S: Effect of Lactobacillus ingestion on the gastrointestinal mucosal barrier alterations induced by indometacin in humans. Aliment Pharmacol Ther 2001;15:11-17.
38.
Pia de la Maza M, Gotteland M, Ramírez C, Araya M, Yudin T, Bunout D, Hirsch S: Acute nutritional and intestinal changes after pelvic radiation. J Am Coll Nutr 2001;20:637-642.
39.
Hollander D: The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol 1992;27:721-726.
40.
Meddings JB, Sutherland LR, Byles NI, Wallace JL: Sucrose: a novel permeability marker for gastroduodenal disease. Gastroenterology 1993;104:1619-1626.
41.
Sutherland LR, Verhoef M, Wallace JL, Van Rosendaal G, Crutcher R, Meddings JB: A simple, non-invasive marker of gastric damage: sucrose permeability. Lancet 1994;343:998-1000.
42.
Meddings JB, Kirk D, Olson ME: Noninvasive detection of nonsteroidal anti-inflammatory drug-induced gastropathy in dogs. Am J Vet Res 1995;56:977-981.
43.
Rabassa AA, Goodgame R, Sutton FM, Ou CN, Rognerud C, Graham DY: Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose. Gut 1996;39:159-163.
44.
Keshavarzian A, Fields JZ, Vaeth J, Holmes EW: The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Am J Gastroenterol 1994;89:2205-2211.
45.
Gotteland M, Araya M, Pizarro F, Olivares M: Effect of acute copper exposure on gastrointestinal permeability in healthy volunteers. Dig Dis Sci 2001;46:1909-1914.
46.
Vogelsang H, Oberhuber G, Wyatt J: Lymphocytic gastritis and gastric permeability in patients with celiac disease. Gastroenterology 1996;111:73-77.
47.
Kwiecien S, Konturek PC, Sliwowski Z, Mitis-Musiol M, Pawlik MW, Brzozowski B, Jasnos K, Magierowski M, Konturek SJ, Brzozowski T: Interaction between selective cyclooxygenase inhibitors and capsaicin-sensitive afferent sensory nerves in pathogenesis of stress-induced gastric lesions. Role of oxidative stress. J Physiol Pharmacol 2012;63:143-151.
48.
Warzecha Z, Dembinski A, Ceranowicz P, Dembinski M, Cieszkowski J, Kownacki P, Konturek PC: Role of sensory nerves in gastroprotective effect of anandamide in rats. J Physiol Pharmacol 2011;62:207-217.
49.
Cohen S, Booth GH Jr: Gastric acid secretion and lower-esophageal-sphincter pressure in response to coffee and caffeine. N Engl J Med 1975;293:897-899.
50.
Moens E, Veldhoen M: Epithelial barrier biology: good fences make good neighbours. Immunology 2012;135:1-8.
51.
Tsugane S: Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci 2005;96:1-6.
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2014
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