A less invasive approach to the treatment of left-sided colonic diverticulitis has emerged in the last decade. The standard of care for perforated or complicated diverticulitis evolved from a Hartmann’s procedure, to resection and primary anastomosis, to treatment with antibiotics and percutaneous drainage in a carefully selected (Hinchey grade 2) patient subset. Recently, laparoscopic lavage emerged as a promising less invasive treatment for selected cases of Hinchey 3 patients. Likewise, for nonperforated or uncomplicated diverticulitis the approach is becoming less aggressive with a change from intravenous antimicrobial therapy, starvation and admission, to oral antibiotics and finally to observation and outpatient treatment. This less invasive or aggressive approach is due to expanding evidence on optimal treatment and is congruent with an increasing understanding that diverticulitis comprises different disease entities with heterogeneity between patients. The disease should be targeted by specific approaches, after a meticulous assessment of the diverticulitis stage, and tailored to an individual basis. Avoidance of overtreatment has obvious benefits: less in-hospital treatment, cost reduction, diminished development of antimicrobial resistance, reduction in complication rate and side effects and presumably a better quality of life for the patient. In conclusion, one might say we have overtreated the majority of diverticulitis patients for decades. More research is needed to explain the pathogenesis and multifactorial etiology and in the near future hopefully several unanswered questions regarding the optimal management of patients with different stages of diverticulitis will be answered by various ongoing trials.

1.
Hartmann H: Process, verbeaux, memoires, et discussions. 30th Congress Francais de Chirurgie, 1921, vol 30, p 411.
2.
Boyden AM: The surgical treatment of diverticulitis of the colon. Ann Surg 1950;132:94–109.
3.
Deans GT, Krukowski ZH, Irwin ST: Malignant obstruction of the left colon. Br J Surg 1994;81:1270–1276.
4.
Koruth NM, Krukowski ZH, Youngson GG, et al: Intraoperative colonic irrigation in the management of left-sided large bowel emergencies. Br J Surg 1985;72:708–711.
5.
Bakker FC, Hoitsma HFW, Den Otter G: The Hartmann procedure. Br J Surg 1982;69:580–582.
6.
Porter JA, Salvati EP, Rubin RJ, et al: Complications of colostomies. Dis Colon Rectum 1989;32:299–303.
7.
Labow SB, Salvati EP, Rubin RJ: The Hartman procedure in the treatment of diverticular disease. Dis Colon Rectum 1973;16:392–394.
8.
Constantinides VA, Heriot A, Remzi F, et al: Operative strategies for diverticular peritonitis: a decision analysis between primary resection and anastomosis versus Hartmann’s procedures. Ann Surg 2007;245:94–103.
9.
Mizuki A, Nagata H, Tatemichi M, et al: The out-patient management of patients with acute mild-to-moderate colonic diverticulitis. Aliment Pharmacol Ther 2005;21:889–897.
10.
O’Sullivan GC, Murphy D, O’Brien MG, et al: Laparoscopic management of generalized peritonitis due to perforated colonic diverticula. Am J Surg 1996;171:432–434.
11.
Taylor CJ, Layani L, Ghusn MA, et al: Perforated diverticulitis managed by laparoscopic lavage. Aust NZ J Surg 2006;76:962–965.
12.
Myers E, Hurley M, O’Sullivan GC, et al: Laparoscopic peritoneal lavage for generalized peritonitis due to perforated diverticulitis. Br J Surg 2008;95:97–101.
13.
Favuzza J, Friel JC, Kelly JJ, et al: Benefits of laparoscopic peritoneal lavage for complicated sigmoid diverticulitis. Int J Colorectal Dis 2009;24:799–801.
14.
Karoui M, Champault A, Pautrat K, et al: Laparoscopic peritoneal lavage or primary anastomosis with defunctioning stoma for Hinchey 3 complicated diverticulitis: results of a comparative study. Dis Colon Rectum 2009;52:609–615.
15.
Ridgway PF, Latif A, Shabbir J, et al: Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis. Colorectal Dis 2009;11:941–946.
16.
Ribas Y, Bombardó J, Aguilar F, et al: Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis. Int J Colorectal Dis 2010;25:1363–1370.
17.
Hjern F, Josephson T, Altman D, et al: Conservative treatment of acute colonic diverticulitis: are antibiotics always mandatory? Scand J Gastroenterol 2007;42:41–47.
18.
De Korte N, Ünlü C, Boermeester MA, et al: Use of antibiotics in uncomplicated diverticulitis. Br J Surg 2011;98:761–767.
19.
De Korte N, Kuijvenhoven JP, van der Peet DL, et al: Mild colonic diverticulitis can be treated without antibiotics. A case-controlled study. Colorectal Dis 2011, Epub ahead of print.
20.
Alonso S, Pera M, Parés D, et al: Outpatient treatment of patients with uncomplicated acute diverticulitis. Colorectal Dis 2010;12:e278–282.
21.
Biondo S, Golda TO: Hospitalization or Ambulatory Treatment of Acute Diverticulitis (01DIVER). 2010. http://clinicaltrials.gov/ct2/show/NCT01081054.
22.
Park HC, Kim BS, Lee BH: Management of right colonic uncomplicated diverticulitis: outpatient versus inpatient management. World J Surg 2011;35:1118–1122.
23.
Etzioni DA, Chiu VY, Cannom RR, et al: Outpatient treatment of acute diverticulitis: rates and predictors of failure. Dis Colon Rectum 2010;53:861–865.
24.
Jacobs DO. Clinical practice. Diverticulitis. N Engl J Med 2007;357:2057–2066.
25.
Heise CP: Epidemiology and pathogenesis of diverticular disease. J Gastrointest Surg 2008;12:1309–1311.
26.
Commane DM, Arasaradnam RP, Mills S, et al: Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World J Gastroenterol 2009;15:2479–2488.
27.
Sharp CK, Zeligman BE, Johnson AM, et al: Evaluation of colonic diverticular disease in autosomal dominant polycystic kidney disease without end-stage renal disease. Am J Kidney Dis 1999;34:863–868.
28.
Taylor RW, Barron MJ, Borthwick GM, et al: Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003;112:1351–1360.
29.
Hinchey EJ, Schaal PG, Richards GK: Treatment of perforated diverticular disease of the colon. Adv Surg 1978;12:85–109.
30.
Morson BC: Pathology of diverticular disease of the colon. Clin Gastroenterol 1975;4:37–52.
31.
Floch MH: A hypothesis: is diverticulitis a type of inflammatory bowel disease? J Clin Gastroenterol 2006;40:S121–S125.
32.
Tursi A, Brandimarte G, Elisei W, et al: Assessment and grading of mucosal inflammation in colonic diverticular disease. J Clin Gastroenterol 2008;42:699–703.
33.
Kellum JM, Sugerman HJ, Coppa GF, et al: Randomized, prospective comparison of cefoxitin and gentamicin-clindamycin in the treatment of acute colonic diverticulitis. Clin Ther 1992;14:376–384.
34.
Fink M, Smith LE, Rosenthal D: Antibiotic choice in the nonoperative management of acute diverticulitis coli. Am Surg 1981;47:201–203.
35.
Ünlü Ç, de Korte N, Daniels L, et al: A multicenter randomized clinical trial investigating the cost-effectiveness of treatment strategies with or without antibiotics for uncomplicated acute diverticulitis (DIABOLO trial). BMC Surg 2010;10:23.
36.
Smedh K: Antibiotic therapy of acute uncomplicated colonic diverticulitis. 2009. http://www.clinicaltrials.gov/ct2/show/NCT01008488.
37.
Chabok A, Påhlman L, Hjern F, et al (AVOD-study group): No value of antibiotics for acute uncomplicated left-sided diverticulitis: a randomised study. Br J Surg 2012;pending publication.
39.
Gooszen AW, Gooszen HG, Veerman W, et al: Operative treatment of acute complications of diverticular disease: primary or secondary anastomosis after sigmoid resection. Eur J Surg 2001;167:35–39.
40.
Masoomi H, Buchberg BS, Magno C, et al: Trends in diverticulitis management in the United States from 2002 to 2007. Arch Surg 2011;146:400–406.
41.
Zehetner J, Szabo K, Wayand W, et al: Lessons learned from the analysis of 200 laparoscopic sigmoid resections for diverticulitis. Surg Laparosc Endosc Percutan Tech 2009;19:123–127.
42.
Klarenbeek BR, Veenhof AA, Bergamaschi R, et al: Laparoscopic sigmoid resection for diverticulitis decreases major morbidity rates: a randomized control trial. Short-term results of the sigma trial. Ann Surg 2009;249:39–44.
43.
Klarenbeek BR, Coupe VMH, van der Peet DL, et al: The cost effectiveness of elective laparoscopic sigmoid resection for symptomatic diverticular disease: financial outcome of the randomized control Sigma trial. Surg Endosc 2011;25:776–783.
44.
Gervaz P, Mugnier-Konrad B, Morel P, et al: Laparoscopic versus open sigmoid resection for diverticulitis: long-term results of a prospective, randomized trial. Surg Endoscop 2011;25:3373–3378.
45.
Salem L, Flum DR: Primary anastomosis or Hartmann’s procedure for patients with diverticular peritonitis? A systematic review. Dis Colon Rectum 2004;47:1953–1964.
46.
Hogan A, Ryan K, Winter D: LapLAND. Laparoscopic Lavage for Acute Non-faeculant Diverticulitis. 2009. http://clinicaltrials.gov/show/NCT010192390.
47.
Swank HA, Vermeulen J, Lange JF, et al: The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitis and Hartmann’s procedure or resection with primary anastomosis for purulent or faecal peritonitis in perforated diverticulitis (NTR2037). BMC Surg 2010;10:29.
48.
Oresland T, Schultz J: Scandinavian Diverticulitis Trial (SCANDIV). Laparoscopic Lavage vs. Primary Resection as Treatment for Perforated Diverticulitis. A Randomized Prospective Multicenter Trial. 2010. http://clinicaltrials.gov/ct2/show/NCT01047462?term=scandiv&rank=1.
49.
Thornell A, Angenete E, Gonzales E, et al: Treatment of acute diverticulitis laparoscopic lavage vs. resection (DILALA): study protocol for a randomised controlled trial. Trials 2011;12:186.
50.
Wong WD, Wexner SD, Lowry A, et al: Practice parameters for the treatment of sigmoid diverticulitis-supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 2000;43:290–297.
51.
Hall JF, Roberts PL, Ricciardi R, et al: Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence? Dis Colon Rectum 2011;54:283–288.
52.
Gervaz P, Platon A, Widmer L, et al: A clinical and radiological comparison of sigmoid diverticulitis episodes 1 and 2. Colorectal Dis DOI: 10.1111/j.1463-1318.2011.02642.x.
53.
Ritz JP, Lehmann KS, Frericks B, et al: Outcome of patients with acute sigmoid diverticulitis: multivariate analysis of risk factors for free perforation. Surgery 2011;149:606–613.
54.
Van de Wall BJM, Draaisma WA, Consten ECJ, et al: DIRECT trial. Diverticulitis recurrences or continuing symptoms: operative versus conservative treatment. A multicenter randomised clinical trial. BMC Surg 2010;10:25.
55.
Ünlü Ç, Daniels L, Vrouenraets BC, et al: A systematic review of high-fibre dietary therapy in diverticular disease. Int J Colorectal Dis DOI: 10.1007/s00384-011-1308-3.
56.
Strate LL, Liu YL, Aldoori WH, et al: Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology 2009;136:115–122.e1.
57.
Turunen P, Wikström H, Carpelan-Holmström M, et al: Smoking increases the incidence of complicated diverticular disease of the sigmoid colon. Scand J Surg 2010;99:14–17.
58.
Porta E, Germano A, Ferrieri A, et al: The natural history of diverticular disease of the colon: a role for antibiotics in preventing complications? A retrospective study. Riv Eur Scj Med Pharmacol 1994;16:33–39.
59.
Dughera L, Serra AM, Battaglia E, et al: Acute recurrent diverticulitis is prevented by administration of a polybacterial lysate suspension. Minerva Gastroenterol Dietol 2004;50:149–153.
60.
White JA: Probiotics and their use in diverticulitis. J Clin Gastroenterol 2006;40:S160–S162.
61.
Tursi A, Brandimarte G, Giorgetti GM, et al: Balsalazide and/or high-potency probiotic mixture (VSL#3) in maintaining remission after attack of acute, uncomplicated diverticulitis of the colon. Int J Colorectal Dis 2007;22:1103–1108.
62.
Lamiki P, Tsuchiya J, Pathak S, et al: Probiotics in diverticular disease of the colon: an open label study. J Gastrointest Liver Dis 2010;19:31–36.
63.
Gatta L, Vakil N, Vaira D, et al: Efficacy of 5-ASA in the treatment of colonic diverticular disease. J Clin Gastroenterol 2010;44:113–119.
64.
Klarenbeek BR, de Korte N, van der Peet DL, et al: Review of current classifications for diverticular disease and a translation into clinical practice. Int J Colorectal Dis 2012;27: 207–214.
65.
Ricciardi R, Baxter NN, Read TE, et al: Is the decline in the surgical treatment for diverticulitis associated with an increase in complicated diverticulitis? Dis Colon Rectum 2009;52:1558–1563.
66.
Laméris W, van Randen A, Bipat S, et al: Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. Eur Radiol 2008;18:2498–2511.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.