Diverticular disease affects up to 50% of people by the time they reach the age of 80. The major complications of diverticular disease (abscess, perforation, fistula, obstruction and bleeding) have their own management pathways, but the treatment of uncomplicated diverticulitis is controversial. On initial presentation, diverticulitis is always treated conservatively. Whether this should be followed by resectional surgery has been the subject of speculation for many decades. The American Society of Colon and Rectal Surgeons recommended in 2000 that an elective resection should follow two attacks of acute diverticulitis. Much of the work underpinning their policy was based on seminal studies by Parks in the 1960s and 1970s who followed cohorts of patients with diverticular disease and examined their outcomes. However, many of these studies were based on inaccurate diagnostic data where the diagnosis was made primarily on clinical grounds. Investigations such as barium enema or colonoscopy are not reliable in confirming the presence of inflammation. Since CT scanning has become routine, the diagnosis of acute diverticulitis can now be made accurately. In recent years much work has been done, such as by Ambrosetti, who has produced evidence predicting the outcome of diverticulitis based on CT findings. More recent papers, in which the diagnosis of acute diverticulitis is likely to have been made more accurately, confirm that although recurrent attacks of diverticulitis are fairly common, there is a very low incidence of serious complications after long-term follow-up. It has also become apparent that the majority of patients who present with the major complications of diverticulitis, specifically abscess, perforation and fistula, do so as their first presentation of the disease, without previous episodes of diverticulitis. The corollary of this is that patients having had acute diverticulitis do not run the risk of developing life-threatening complications without elective surgery. The complications of left-sided colonic resection are not inconsiderable with anastomotic leaks, the formation of a stoma, either temporary or permanent, as well as mortality. When these data are put alongside the very low risk of serious harm to the patient after diverticulitis, the balance of opinion has now swung heavily in favour of a more conservative approach. In addition to this there are modern and innovative medical therapeutic approaches to the treatment of diverticulitis such as 5ASAs, poorly absorbed antibiotics and probiotics.

1.
Goldacre M, Duncan M, Cook-Mozaffari P, Davidson M, McGuiness H, Meddings D: Diverticular disease in England 1996–2004. Unit of Health Care Epidemiology, Oxford University & South East England Public Health Observatory, 2006.
2.
McConnell EJ, Tessier DJ, Wolff BG: Population-based incidence of complicated diverticular disease of the sigmoid colon based on gender and age. Dis Colon Rectum 2003;46:1110–1114.
3.
Flashman K, Howell R, O’Leary DP, Senapati A, Thompson MR: Epidemiology and symptoms of uncomplicated diverticular disease. Colorectal Dis 2004;6(suppl 1):31–32.
4.
Parks TG: Natural history of diverticular disease of the colon. A review of 521 cases. Br Med J 1969;iv:639–642.
5.
Killingback M: Management of perforative diverticulitis. Surg Clin North Am 1983;63:97–115.
6.
Makela J, Kiviniemi H, Laitinen S: Prevalence of perforated sigmoid diverticulitis is increasing. Dis Colon Rectum 2002;45:955–961.
7.
Hart AR, Kennedy HJ, Stebbings WS, Day NE: How frequently do large bowel diverticula perforate? An incidence and cross-sectional study. Eur J Gastroenterol Hepatol 2000;12:661–665.
8.
Humes DJ, Solaymani-Dodaran M, Fleming KM, Simpson J, Spiller RC, West J: A population-based study of perforated diverticular disease incidence and associated mortality. Gastroenterology 2009;136:1198–1205.
9.
McConnell EJ, Tessier DJ, Wolff BG: Population-based incidence of complicated diverticular disease of the sigmoid colon based on gender and age. Dis Colon Rectum 2003;46:1110–1114.
10.
National Confidential Enquiry into Patients Outcome & Death, 2011.
11.
Papagrigoriadis S, Debrah S, Koreli A, Husain A: Impact of diverticular disease on hospital costs and activity. Colorectal Dis 2004;6:81–84.
12.
Constantinides VA, Tekkis PP, Senapati A: Prospective multicentre evaluation of adverse outcomes following treatment for complicated diverticular disease. Br J Surg 2006;93:1503–1513.
13.
Hyland JM, Taylor I: Does a high fibre diet prevent the complications of diverticular disease? Br J Surg 1980;67:77–79.
14.
Tudor RG, Farmakis N, Keighley MR: National audit of complicated diverticular disease: analysis of index cases. Br J Surg 1994;81:730–732.
15.
Sarin S, Boulos PB: Long-term outcome of patients presenting with acute complications of diverticular disease. Ann R Coll Surg Engl 1994;76:117–120.
16.
Tan L, Senapati A, Thompson MR: Early flexible sigmoidoscopy in the evaluation of acute left iliac fossa pain. Colorectal Dis 2000;2:84–87.
17.
Ambrosetti P, Robert JH, Witzig JA, et al: Acute left colonic diverticulitis: a prospective analysis of 226 consecutive cases. Surgery 1994;115:546–550.
18.
Elliott TB, Yego S, Irvin TT: Five-year audit of the acute complications of diverticular disease. Br J Surg 1997;84:535–539.
19.
Makela J, Vuolio S, Kiviniemi H, Laitinen S: Natural history of diverticular disease: when to operate? Dis Colon Rectum 1998;41:1523–1528.
20.
Biondo S, Pares D, Marti RJ, Kreisler E, Fraccalvieri D, Jaurrieta E: Acute colonic diverticulitis in patients under 50 years of age. Br J Surg 2002;89:1137–1141.
21.
Chautems RC, Ambrosetti P, Ludwig A, Mermillod B, Morel P, Soravia C: Long-term follow-up after first acute episode of sigmoid diverticulitis: is surgery mandatory? A prospective study of 118 patients. Dis Colon Rectum 2002;45:962–966.
22.
Mueller MH, Glatzie J, Kasparek MS, Becker HD, Jehle EC, Zittel TT et al: Long term outcome of conservative treatment in patients with diverticulitis of the sigmoid colon. Eur J Gastroenterol Hepatol 2005;6:649–654.
23.
Anaya DA, Flum DR: Risk of emergency colectomy and colostomy in patients with diverticular disease. Arch Surg 2005;140:681–685.
24.
Moreno AM, Wille-Jorgensen P: Long-term outcome in 445 patients after diagnosis of diverticular disease. Colorectal Dis 2007;9:464–468.
25.
Salem TA, Molloy RG, O’Dwyer PJ: Prospective, five-year follow-up study of patients with symptomatic uncomplicated diverticular disease. Dis Colon Rectum 2007;50:1460–1464.
26.
Hall JF, Roberts PL, Ricciardi R, et al: Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence? Dis Colon Rectum 2011;54:283–288.
27.
Ricciardi R, Baxter NN, Read TE, Marcello PW, Hall J, Roberts PL: Is the decline in the surgical treatment for diverticulitis associated with an increase in complicated diverticulitis? Dis Colon Rectum 2009;52:1558–1563.
28.
Chapman JR, Dozois EJ, Wolff BG, Gullerud RE, Larson DR: Diverticulitis: a progressive disease? Do multiple recurrences predict less favorable outcomes? Ann Surg 2006;243:876–830.
29.
Nylamo E: Diverticulitis of the colon: role of surgery in preventing complications. Ann Chir Gynaecol 1990;79:139–142.
30.
Lorimer JW: Is prophylactic resection valid as an indication for elective surgery in diverticular disease? Can J Surg 1997;40:445–448.
31.
Somasekar K, Foster ME, Haray PN: The natural history diverticular disease: is there a role for elective colectomy? J R Coll Surg Edinb 2002;47:481–482, 484.
32.
Andeweg C, Peters J, Bleichrodt R, et al: Incidence and risk factors of recurrence after surgery for pathology-proven diverticular disease. World J Surg 2008;32:1501–1506.
33.
Rafferty J, Shellito P, Hyman NH, Buie WD: Practice parameters for sigmoid diverticulitis. Dis Colon Rectum 2006;49:939–944.
34.
Breen RE, Corman ML, Robertson WG, Prager ED: Are we really operating on diverticulitis? Dis Colon Rectum 1986;29:174–176.
35.
Thorn M, Graf W, Stefansson T, Pahlman L: Clinical and functional results after elective colonic resection in 75 consecutive patients with diverticular disease. Am J Surg 2002;183:7–11.
36.
Killingback M, Barron PE, Dent OF: Elective surgery for diverticular disease: an audit of surgical pathology and treatment. Aust NZ J Surg 2004;74:530–536.
37.
Egger B, Peter MK, Candinas D: Persistent symptoms after elective sigmoid resection for diverticulitis. Dis Colon Rectum 2008;51:1044–1048.
38.
Benn PL, Wolff BG, Ilstrup DM: Level of anastomosis and recurrent colonic diverticulitis. Am J Surg 1986;151:269–271.
39.
Munson KD, Hensien MA, Jacob LN, Robinson AM, Liston WA: Diverticulitis. A comprehensive follow-up. Dis Colon Rectum 1996;39:318–322.
40.
Thaler K, Dinnewitzer A, Mascha E, Arrigain S, Weiss EG, Nogueras JJ et al: Long-term outcome and health-related quality of life after laparoscopic and open colectomy for benign disease. Surg Endosc 2003;17:1404–1408.
41.
Alvarez JA, Baldonedo RF, Bear IG, Otero J, Pire G, Alvarez P et al: Presentation, management and outcome of acute sigmoid diverticulitis requiring hospitalization. Dig Surg 2007;24:471–476.
42.
Oomen JL, Engel AF, Cuesta MA: Mortality after acute surgery for complications of diverticular disease of the sigmoid colon is almost exclusively due to patient related factors. Colorectal Dis 2006;8:112–119.
43.
Ambrosetti P, Robert J, Witzig JA, et al: Prognostic factors from computed tomography in acute left colonic diverticulitis. Br J Surg 1992;79:117–119.
44.
Ambrosetti P, Grossholz M, Becker C, Terrier F, Morel P: Computed tomography in acute left colonic diverticulitis. Br J Surg 1997;84:532–534.
45.
Wong WD, Wexner SD, Lowry A, et al: Practice parameters for the treatment of sigmoid diverticulitis–supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 2000;43:290–297.
46.
Etzioni DA, Cannom RR, Ault GT, Beart RW Jr, Kaiser AM: Diverticulitis in California from 1995 to 2006: increased rates of treatment for younger patients. Am Surg 2009;75:981–985.
47.
Janes S, Meagher A, Frizelle FA: Elective surgery after acute diverticulitis. Br J Surg 2005;92:133–142.
48.
Chapman J, Davies M, Wolff B, et al: Complicated diverticulitis: is it time to rethink the rules? Ann Surg 2005;242:576–581.
49.
Fozard JB, Armitage NC, Schofield JB, Jones OM: ACPGBI position statement on elective resection for diverticulitis. Colorectal Dis 2011;13(suppl 3):1–11.
50.
Trivedi CD, Das KM: Emerging therapies for diverticular disease of the colon. J Clin Gastroenterol 2008;42:1145–1151.
51.
Comparato G, Fanigliulo L, Cavallaro LG, Aragona G, Cavestro GM, Iori V et al: Prevention of complications and symptomatic recurrences in diverticular disease with mesalazine: a 12-month follow-up. Dig Dis Sci 2007;52:2934–2941.
52.
Floch MH, Madsen KK, Jenkins DJ, et al: Recommendations for probiotic use. J Clin Gastroenterol 2006;40:275–278.
53.
Jeyarajah S, Papagrigoriadis S: Diverticular disease increases and effects younger ages: an epidemiological study of 10-year trends. Int J Colorectal Dis 2008;23:619–627.
54.
Faria GR, Almeida AB, Moreira H, Pinto-de-Sousa J, Correia-da-Silva P, Pimenta AP: Acute diverticulitis in younger patients: any rationale for a different approach? World J Gastroenterol 2011;17:207–212.
55.
Makela JT, Kiviniemi HO, Laitinen ST: Acute sigmoid diverticulitis in young patients. Hepatogastroenterology 2009;56:1382–1387.
56.
Guzzo J, Hyman N: Diverticulitis in young patients: is resection after a single attack always warranted? Dis Colon Rectum 2004;47:1187–1190.
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