Renal candidiasis in neonates and young infants is a potentially life threatening condition. It occurs mainly in neonates and young infants with secondary risk factors and underlying congenital urinary tract abnormalities. The diagnosis can easily be established and is usually followed by antifungal therapy with fluconazole. However, fluconazole therapy might fail and there seems to be no consensus on best second-line therapy. We describe 4 patients with renal candidiasis, which illustrate the different aspects to be considered during treatment. A literature study was performed to search for the best therapeutic modality to achieve cure. Based on the few papers that describe the management of invasive candidiasis and the experience with the 4 cases, a therapy protocol is proposed in which systemic antifungal therapy is combined with an irrigation procedure.

Keywords:
Candida, Kidney, Infection, Nephrostomy, Irrigation
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© 2007 S. Karger AG, Basel
2008
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