Cystometry of the conscious rat is an effective method to study bladder function without compromising micturition reflexes with anesthetics. This model can be influenced by inflammation, hormones and potentially strain of animal. Therefore, we examined whether gender has any impact on the micturition pattern of Sprague-Dawley (SD), Wistar Kyoto (WKY) and Spontaneously Hypertensive rat (SHR). In this study, recovery after surgery had a major impact on cystometry during the early days of post-surgery. Void intervals were shorter with very low void volume on the first day after surgery. However, there was a gradual increase in void interval and void volume from the second day onwards and were stable on the fifth through seventh days post-surgery. Regarding strains, it was found that void volume and void interval were similar between SD and WKY rat. SHR, had a lower void volume with a shorter void interval than the WKY. Interestingly,the void interval in male rats, regardless of strain,was shorter compared to the females of the respective strain. It is concluded that a stable cystometric pattern is observed in the conscious SD rat after the fifth day of post-surgery which suggests that at least 1 week should be allowed after bladder surgery to observe a stable cystometric data. There was a clear sex difference in the micturition pattern among the strains in that the frequency of micturition of the male was higher than female SD, WKY and SHR. Studying the sex differences in the micturition pattern might improve understanding the different pathophysiology of bladder control in men and women.

This content is only available via PDF.
2008
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.