... is dexamethasone. Dexamethasone is known to cause skeletal muscular weakness and when used for an extended period of time, skeletal muscle undergoes atrophy. Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that helps mobilize stem cells from bone marrow into peripheral circulation. In order...

...Alexie A. Larson; Brian C. Syverud; Shelby E. Florida; Brittany L. Rodriguez; Molly N. Pantelic; Lisa M. Larkin Our lab showed that administration of dexamethasone (DEX) stimulated myogenesis and resulted in advanced structure in our engineered skeletal muscle units (SMU). While administration...

... microenvironments as similar as possible to those that would normally occur in vivo. In the case of skeletal muscle, the development of such a culture model, integrating multiple relevant cell types within a biomimetic scaffold, would be of significant benefit for investigations into the development, functional...

...Alastair Khodabukus; Keith Baar Tissue-engineered skeletal muscle has the promise to be a tool for studying physiology, screening muscle-active drugs, and clinical replacement of damaged muscle. To maximize the potential benefits of engineered muscle, it is important to understand the factors...

... and regenerative capacities of mammalian skeletal muscle. Given the nature of VML injuries, there is a clear need to develop therapies that promote de novo regeneration of skeletal muscle fibers, which can integrate with the remaining musculature and restore muscle strength. However, the pathophysiology of VML...

...Juliana A. Passipieri; George J. Christ Despite the robust regenerative capacity of skeletal muscle, there are a variety of congenital and acquired conditions in which the volume of skeletal muscle loss results in major permanent functional and cosmetic deficits. These latter injuries are referred...

...Brian C. Syverud; Keith W. VanDusen; Lisa M. Larkin Tissue-engineered skeletal muscle holds promise as a source of graft tissue for repair of volumetric muscle loss and as a model system for pharmaceutical testing. To reach this potential, engineered tissues must advance past the neonatal phenotype...

... of these fibers past the time of weaning. We quantified proportions of hybrid fibers in three different mouse skeletal muscles from newly weaned to 6-month-old mice. Hybrid fibers were very prevalent in the brachioradialis (BR) and tibialis anterior (TA) muscles from newly weaned mice, where they constituted 50...

... steps in myogenesis. However, it remains to be established whether myostatin, a member of the TGF-β superfamily, affects chemokine expression in skeletal muscle. We investigated the effects of myostatin on the expression of mRNAs and proteins for 4 chemokines (CXCL1, CXCL2, CXCL6, CCL2) in intact...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Skeletal muscle Fiber types Jaw...

... Immunohistochemistry Skeletal muscle Stem cell biology Mouse Tissue-specific stem cells contribute to the regeneration and maintenance of most organs of mammals including blood, liver, intestine, skeletal muscle and central nervous system. For decades it has been assumed that tissue-specific stem...

... increased the passive muscle force due to the increase in the muscle stiffness rather than the shift of the muscle slack length. 22 06 2007 15 10 2007 In a resting skeletal muscle (that is, a muscle belly including sarcomeres, endosarcometric and exosarcometric cytoskeletons, and epi...

...Veit Wank; Martin S. Fischer; Bernd Walter; Reinhard Bauer Rapid postnatal development in pigs is reflected by differentiation in skeletal muscle. This process depends on muscle function and demands, but a comprehensive overview of individual developmental characteristics of quickly growing leg...

... found that three MHC isoforms are expressed in dog skeletal muscles. The pattern of their expressions determined the existence of ‘pure’ fibres, i.e. I and IIa, both expressing only one MHC isoform, and ‘hybrid’ fibres, i.e. I/IIa and IIa/x, that co-expressed two MHC isoforms. While the MHCI, MHCIIa...

... comparative studies of morphofunctional adaptive changes in skeletal muscle. A significant difference between individuals (animals) in all parameters was evident and should be taken into consideration when analysing the variability: the factor ‘animal’ should be considered in multiway ANOVAs, especially when...