...Qi Chen; Fangfang Shi; Chen Yang; Guangfeng Mao; Chunguang Zhou; Limin Liu; Xi Yang; Yueming Song Hypoxia-inducible factor (HIF) plays a crucial role in regulating the hypoxia-inducible state of nucleus pulposus cells in the intervertebral disc. In addition, the oxygen-dependent conversion of HIF...

... higher levels of osteogenesis in vivo. Finally, when incorporated as the endplate region of a larger tissue-engineered intervertebral disc replacement, HA coating did not induce mineralization in or promote cell migration out of neighboring biomaterials. Overall, these results verified tunable biomimetic...

...Xue Yin; Silvia Gonzales; Somya Sha; Howard Levene; Chun-Yuh Huang Compressive loading promotes adenosine triphosphate (ATP) production and release by intervertebral disc (IVD) cells. Extracellular ATP can be rapidly hydrolyzed by ectonucleotidases. Adenosine, one of the adenine derivatives of ATP...

...Hao Li; Jingkai Wang; Fangcai Li; Gang Chen; Qixin Chen Nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) are suitable cell candidates for intervertebral disc (IVD) regeneration. However, little work has been done to determine the proliferation and chondrogenic differentiation of NP-MSCs...

...Zhao Huang; Benjamin Kohl; Maria Kokozidou; Stephan Arens; Gundula Schulze-Tanzil Tissue-engineered intervertebral discs (IVDs) utilizing decellularized extracellular matrix (ECM) could be an option for the reconstruction of impaired IVDs due to degeneration or injury. The objective of this study...

...Zhengjian Yan; Liangjun Yin; Zhongliang Wang; Jixing Ye; Zhonglin Zhang; Ruifang Li; Sahitya K. Denduluri; Jing Wang; Qiang Wei; Lianggong Zhao; Shun Lu; Xin Wang; Shengli Tang; Lewis L. Shi; Michael J. Lee; Tong-Chuan He; Zhong-Liang Deng The intervertebral disc (IVD) is a fibrocartilaginous joint...

...Bin Han; Hai-chao Wang; Hao Li; Yi-qing Tao; Cheng-zhen Liang; Fang-cai Li; Gang Chen; Qi-xin Chen The microenvironment of the intervertebral disc (IVD) is characterized by matrix acidity, hypoxia, hyperosmolarity and limited nutrition, which are major obstacles to stem cell-based regeneration. Our...

...Hao Li; Yiqing Tao; Chengzhen Liang; Bin Han; Fangcai Li; Gang Chen; Qixin Chen Adipose-derived mesenchymal stem cells (ADMSCs) and nucleus pulposus-derived mesenchymal stem cells (NPMSCs) are two cell candidates for cell-based therapies for intervertebral disc (IVD) regeneration. However, little...

...Helena Barreto Henriksson; Helena Brisby At the present time, the normal cell proliferation rate and regeneration processes in the intervertebral disc (IVD) are not fully known. Historically, the IVD has been considered an organ with little or no regenerative capacity. However, several studies have...