...Pierre Savagner; Thomas Brabletz; Chonghui Cheng; Christine Gilles; Tian Hong; Myriam Polette; Guojun Sheng; Marc P. Stemmler; Erik W. Thompson This report summarizes the 10th biennial meeting of The Epithelial Mesenchymal Transition International Association (TEMTIA), that took place in Paris...

... such as metastasis, therapy resistance, and immune evasion. The process of cells attaining one or more hybrid E/M phenotypes is termed as partial epithelial mesenchymal transition (EMT). Cells in hybrid E/M phenotype(s) can be more aggressive than those in either fully epithelial or mesenchymal state. Thus...

... of self-renewal capabilities of progenitors and cancer stem cells. A regulatory network and mathematical model based on tumor histology and molecular signatures predicted hypoxia-inducible factor 1-alpha (HIF1A) as a central node connecting HA synthesis, epithelial-mesenchymal transition, metabolic...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. TEMTIA-IX Epithelial-mesenchymal transition Mesenchymal-epithelial transition...

...Jingyi Lyu; Chonghui Cheng Alternative splicing is an essential mechanism of gene regulation, giving rise to remarkable protein diversity in higher eukaryotes. Epithelial-mesenchymal transition (EMT) is a developmental process that plays an essential role in metazoan embryogenesis. Recent studies...

... research in the first place? For more than 50 years after its inception, epithelial-mesenchymal transition (EMT) research has been catalyzed by cross-disciplinary interactions between developmental, cell, and cancer biologists. Among those, two Australian scientists, Erik Thompson, a cancer...

..., epithelial cells undergo some degree of epithelial-mesenchymal transition (EMT), whereby cells from opposing sheets dissolve existing cell-cell junctions, degrade the basement membrane, extend motile processes to contact each other, and then re-establish cell-cell junctions as they fuse. Similar events occur...

..., mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus playing an important role during cancer cell metastasis. Due to their central role in differentiation...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Non-small-cell lung cancer Epithelial-mesenchymal transition Therapy...

... markers E-cadherin and zonula occludens-1 (ZO-1) decreases while expression of the mesenchymal markers N-cadherin, vimentin, S100A4, and MMP-9 increases. Cells become motile and move through the basement membrane into the underlying lamina propria. Epithelial-mesenchymal transition (EMT...

...Reem Malek; Hailun Wang; Kekoa Taparra; Phuoc T. Tran Mounting data points to epithelial plasticity programs such as the epithelial-mesenchymal transition (EMT) as clinically relevant therapeutic targets for the treatment of malignant tumors. In addition to the widely realized role of EMT...

... Deleted in colorectal carcinoma Neogenin Frazzled UNC-5 Epithelial mesenchymal plasticity Epithelial-mesenchymal transition Mesenchymal-epithelial transition Netrins are secreted laminin-related chemotactic proteins that are thought to form concentration gradients in vivo, which can...

...Catherine L. Carmichael; Jody J. Haigh Snail family proteins are key inducers of the epithelial-mesenchymal transition (EMT), a critical process required for normal embryonic development. They have also been strongly implicated in regulating the EMT-like processes required for tumour cell invasion...

...Duane H. Hamilton; Justin M. David; Charli Dominguez; Claudia Palena Epithelial-mesenchymal transition (EMT) is recognized as a relevant process during the progression of carcinomas towards metastatic disease. Epithelial cancer cells undergoing an EMT program may acquire mesenchymal features...

...- and GalNAc-terminating glycans were similarly expressed on the glycocalyx of the mesenchymal cell populations (EMTCs and AMCs). These results demonstrate for the first time that the spontaneous epithelial-mesenchymal transition (EMT) of equine amnion cells is characterized by cell surface glycan remodeling...

...Nur Akmarina B.M. Said; Kaylene J. Simpson; Elizabeth D. Williams Enormous progress has been made towards understanding the role of specific factors in the process of epithelial-mesenchymal transition (EMT); however, the complex underlying pathways and the transient nature of the transition...

...Bin Huang; Lei Pi; Cha Chen; Fei Yuan; Qingsong Zhou; Junqi Teng; Tang Jiang Mature tubular epithelial cells in the adult kidney can undergo epithelial-mesenchymal transition (EMT), a phenotypic change that is linked to the pathogenesis of renal interstitial fibrosis. EMT may be considered...

...András Masszi; András Kapus Epithelial-mesenchymal transition (EMT) has emerged as a major mechanism in the pathogenesis of organ fibrosis. The epithelium has been proposed to be a significant source of matrix-producing fibroblasts and of myofibroblasts (MFs), a motile and contractile cell type...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epithelial-mesenchymal transition Growth factor Cancer Epithelial to mesenchymal transition (EMT) is a process well recognized in embryological development...

...Yukiko Nakaya; Erike W. Sukowati; Cantas Alev; Fumie Nakazawa; Guojun Sheng Regulated disruption of the basement membrane (BM) is a critical step in many epithelial-mesenchymal transition (EMT) processes. Molecular mechanisms controlling the interaction between the BM and the basal membrane...