...Elisa Capuana; Davide Marino; Roberto Di Gesù; Vincenzo La Carrubba; Valerio Brucato; Rocky S. Tuan; Riccardo Gottardi Articular cartilage is crucially influenced by loading during development, health, and disease. However, our knowledge of the mechanical conditions that promote engineered...

...M. Rita Correro-Shahgaldian; Chafik Ghayor; Nicholas D. Spencer; Franz E. Weber; Luigi M. Gallo Mechanical stress is listed as a main risk factor for cartilage degradation. The aim of this study was to investigate the biological response of cartilage to dynamic loading such as plowing. Cartilage...

...Gregory J. Wright; Kelvin G.M. Brockbank; Eliza Rahn; Dina O. Halwani; Zhen Chen; Hai Yao Various preservation solutions have been evaluated for longer hypothermic cartilage storage for tissue transplantation; however, the results are mixed. This research was carried out to determine whether...

...In Ho Jeong; Asode Ananthram Shetty; Seok Jung Kim; Jae Deog Jang; Young Ju Kim; Yang Guk Chung; Nam Yong Choi; Chung Hsuan Liu For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture...

...Daniel J. Huey; Kyriacos A. Athanasiou Articular cartilage and the menisci of the knee joint lack intrinsic repair capacity; thus, injuries to these tissues result in eventual osteoarthrotic changes to the joint. Tissue engineering offers the potential to replace damaged cartilage and mitigate long...

...K.H. Sitoci; M. Hudelmaier; F. Eckstein Magnetic resonance imaging (MRI) allows one to analyze cartilage physiology in vivo . Cartilage deforms during loading, but little is known about its recovery after deformation. Here we study ‘nocturnal’ changes in knee cartilage thickness and whether...

...Ala Qusous; Magdalena Kaneva; Vedia C. Can; Stephen J. Getting; Mark J.P. Kerrigan In cartilage research bovine articular cartilage is used as an alternative to human tissue. However, animal material is subject to availability and primary cultures undergo senescence, limiting their use. Here we...

...Haiyan Chen; Farah Y. Ghori-Javed; Harunur Rashid; Rosa Serra; Soraya E. Gutierrez; Amjad Javed Coordinated activities of multiple mesenchymal cell types contribute to the development of the mammalian skeleton formed through endochondral ossification. Synthesis of a cartilage template...

...Seika Matsushima; Noritaka Isogai; Robin Jacquet; Elizabeth Lowder; Taku Tokui; William J. Landis This study was undertaken to determine whether periosteum from different bone sources in a donor results in the same formation of bone and cartilage. In this case, periosteum obtained from the cranium...

...M. Hudelmaier; W. Wirth; B. Wehr; V. Kraus; B.T. Wyman; M.-P. Hellio Le Graverand; F. Eckstein This study was designed to characterize the reproducibility and sensitivity to change of magnetic resonance imaging-based cartilage morphology metrics and femoral regions of interest (ROIs), in order...

...S. Cotofana; S. Ring-Dimitriou; M. Hudelmaier; M. Himmer; W. Wirth; A.M. Sänger; F. Eckstein Introduction: Epidemiological studies show a positive relationship between physical activity and cartilage volume, suggesting that exercise may protect against osteoarthritis. Cross-sectional experimental...

...Alexander T. Hillel; Janis M. Taube; Toby C. Cornish; Blanka Sharma; Marc Halushka; Edward F. McCarthy; Grover M. Hutchins; Jennifer H. Elisseeff The production of engineered cartilage from mesenchymal stem cells is a rapidly developing field. Potential applications include the treatment...

...Teemu K. Långsjö; Machiko Arita; Heikki J. Helminen The objective was to investigate by electron microscopic stereology the properties of the cartilage collagen fibril network in newborn transgenic mice. The mice harbored transgenes targeted to affect the structure or assembly of the collagen...

... Cartilage Injured cartilage in adults usually leads to osteoarthritic changes of the joint because articular cartilage has a limited capacity for self-repair [Buckwalter et al., 1998]. A lot of trials and investigations have been performed to provide a breakthrough for this difficult problem...

...Enrico Tognana; Anna Borrione; Claudio De Luca; Alessandra Pavesio Articular cartilage injuries have poor reparative capability and, if left untreated, may progress to osteo-arthritis. Unsatisfactory results with conventional treatment methods have prompted the development of innovative solutions...

... an environment of optimal regulatory protein expression and would have many benefits in various areas such as the transplantation of skin, cartilage or bone. The aim of this review is to outline tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic...

... spectrometer (EDX). Measurements of the thickness and cell density in the superficial and deep layers of epiglottic cartilage were performed in horizontal histological sections. No significant differences in macroscopic width or height were found across the age groups in either sex. A series of three...

... of epiphyseal cartilage and in chondrocytes of the deep zone of mature articular cartilage, where extracellular matrix was also stained. OPN expression was strongest in 4.5-month-old puppies in cells of the osteoblastic lineage. It also varied with microlocation and was pronounced in areas prone to resorption...

...Jarno Rieppo; Juha Töyräs; Miika T. Nieminen; Vuokko Kovanen; Mika M. Hyttinen; Rami K. Korhonen; Jukka S. Jurvelin; Heikki J. Helminen The present study is aimed at revealing structure-function relationships of bovine patellar articular cartilage. Collagenase, chondroitinase ABC and elastase were...

... regarding joint classification. In adult rats (both males and females, including intrapartum specimens), our results confirm those of earlier studies showing that the interpubic joint contains a central core of hyaline cartilage surrounded by fibrocartilaginous areas. Thus, in rats, the pubic joint should...