This report summarizes the 10th biennial meeting of The Epithelial Mesenchymal Transition International Association (TEMTIA), that took place in Paris on November 7–10, 2022. It provides a short but comprehensive introduction to the presentations and discussions that took place during the 3-day meeting. Similarly to previous TEMTIA meetings, TEMTIA X reviewed the most recent aspects of the epithelial-mesenchymal transition (EMT), a cellular process involved during distinct stages of development but also during wound healing and fibrosis to some degree. EMT has also been associated at various levels during tumor cell progression and metastasis. The meeting emphasized the intermediate stages of EMT (partial EMT or EM hybrid cells) involved in the malignant process and their potential physiological or pathological importance, taking advantage of advancements in molecular methods at the single-cell level. It also introduced novel descriptions of EMT occurrences during early embryogenesis. Sessions explored relationships between EMT and cell metabolism and how EMT can affect immune responses, particularly during tumor progression, providing new targets for cancer therapy. Finally, it introduced a new perception of EMT biological meaning based on an evolutionary perspective. The meeting integrated the TEMTIA general assembly, allowing general discussion about the future of the association and the site of the next meeting, now decided to take place in Seattle, USA, in November 2024. This report provides a comprehensive introduction to the presentations and discussions that took place during the 10th biennial meeting of TEMTIA, that occurred in Paris on November 7–10, 2022. It includes all the sessions and follows the chronological order during the 3-day meeting. A general purpose of the meeting was to explore the boundaries of the EMT process, including new concepts and developments, as illustrated by our leitmotiv for the meeting, inspired by the proximity of the Cluny Museum in Paris.

1.
Yang
J
,
Antin
P
,
Berx
G
,
Blanpain
C
,
Brabletz
T
,
Bronner
M
.
Guidelines and definitions for research on epithelial–mesenchymal transition
.
Nat Rev Mol Cell Biol
.
2020
;
21
(
6
):
341
52
.
2.
Bergers
G
,
Fendt
S-M
.
The metabolism of cancer cells during metastasis
.
Nat Rev Cancer
.
2021
;
21
(
3
):
162
80
.
3.
Müller
S
,
Sindikubwabo
F
,
Cañeque
T
,
Lafon
A
,
Versini
A
,
Lombard
B
.
CD44 regulates epigenetic plasticity by mediating iron endocytosis
.
Nat Chem
.
2020
;
12
(
10
):
929
38
.
4.
Bhattacharya
D
,
Khan
B
,
Simoes-Costa
M
.
Neural crest metabolism: at the crossroads of development and disease
.
Dev Biol
.
2021
;
475
:
245
55
.
5.
Guen
VJ
,
Chavarria
TE
,
Kröger
C
,
Lees
JA
.
EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling
.
Proc Natl Acad Sci
.
2017
114
49
E10532
9
.
6.
Gouignard
N
,
Bibonne
A
,
Mata
JF
,
BajancaBerki
FB
,
Barriga
EH
.
Paracrine regulation of neural crest EMT by placodal MMP28
.
PLoS Biol
.
2023
;
21
(
8
):
e3002261
.
7.
Campbell
K
,
Lebreton
G
,
Franch-Marro
X
,
Casanova
J
.
Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth
.
PLoS Genet
.
2018
;
14
(
2
):
e1007167
.
8.
Hultgren
NW
,
Fang
JS
,
Ziegler
ME
,
Ramirez
RN
,
Phan
DTT
,
Hatch
MMS
.
Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
.
Nat Commun
.
2020
;
11
(
1
):
5400
.
9.
Zhao
J
,
Patel
J
,
Kaur
S
,
Sim
SL
,
Wong
HY
,
Styke
C
.
Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
.
Nat Commun
.
2021
;
12
(
1
):
2564
.
10.
Fumagalli
A
,
Oost
KC
,
Kester
L
,
Morgner
J
,
Bornes
L
,
Bruens
L
.
Plasticity of lgr5-negative cancer cells drives metastasis in colorectal cancer
.
PLoS Biol
.
2020
;
26
(
4
):
569
78.e7
.. DOI:
11.
Pastushenko
I
,
Blanpain
C
.
EMT transition states during tumor progression and metastasis
.
Trends Cell Biol
.
2019
;
29
(
3
):
212
26
.
12.
Clark
AG
,
Maitra
A
,
Jacques
C
,
Bergert
M
,
Pérez-González
C
,
Simon
A
.
Self-generated gradients steer collective migration on viscoelastic collagen networks
.
Nat Mater
.
2022
;
21
(
10
):
1200
10
.
13.
Fattet
L
,
Jung
HY
,
Matsumoto
MW
,
Aubol
BE
,
Kumar
A
,
Adams
JA
.
Matrix rigidity controls epithelial-mesenchymal plasticity and tumor metastasis via a mechanoresponsive EPHA2/LYN complex
.
Dev Cell
.
2020
;
54
(
3
):
302
16.e7
.
14.
Tsirigoti
C
,
Ali
MM
,
Maturi
V
,
Heldin
CH
,
Moustakas
A
.
Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
.
Cell Death Dis
.
2022
;
13
(
9
):
832
.
15.
Schuhwerk
H
,
Menche
C
,
Armstark
I
,
Gupta
P
,
Fuchs
K
,
van Roey
R
.
ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer
.
bioRxiv
.
2023
.
16.
Kim
I-K
,
Diamond
M
,
Yuan
S
,
Kemp
S
,
Li
Q
,
Lin
J
.
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy
.
Res Sq
.
2023
.
17.
Dongre
A
,
Rashidian
M
,
Eaton
EN
,
Reinhardt
F
,
Thiru
P
,
Zagorulya
M
.
Direct and indirect regulators of epithelial-mesenchymal transition-mediated immunosuppression in breast carcinomas
.
Cancer Discov
.
2021
;
11
(
5
):
1286
305
.
18.
Terry
S
,
Savagner
P
,
Ortiz-Cuaran
S
,
Mahjoubi
L
,
Saintigny
P
,
Thiery
JP
.
New insights into the role of EMT in tumor immune escape
.
Mol Oncol
.
2017
;
11
(
7
):
824
46
.. DOI.org/
19.
Tan
X
,
Xiao
G-Y
,
Wang
S
,
Shi
L
,
Zhao
Y
,
Liu
X
.
EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer
.
J Clin Invest
.
2023
;
133
(
7
):
e165863
.
20.
Moorman
A
,
Cambuli
F
,
Benitez
E
,
Jiang
Q
,
Xie
Y
,
Mahmoud
A
.
Progressive Plasticity during colorectal cancer metastasis
.
bioRxiv
.
2023
08.18.2023.08.18.553925
.
21.
Qiu
X
,
Zhang
Y
,
Martin-Rufino
JD
,
Weng
C
,
Hosseinzadeh
S
,
Yang
D
.
Mapping transcriptomic vector fields of single cells
.
Cell
.
2022
;
185
(
4
):
690
711.e45
.
22.
Pang
QY
,
Tan
TZ
,
Sundararajan
V
,
Chiu
YC
,
Chee
EYW
,
Chung
VY
.
3D genome organization in the epithelial-mesenchymal transition spectrum
.
Genome Biol
.
2022
;
23
(
1
):
121
.
23.
Johnson
KS
,
Hussein
S
,
Chakraborty
P
,
Muruganantham
A
,
Mikhail
S
,
Gonzalez
G
.
CTCF expression and dynamic motif accessibility modulates epithelial-mesenchymal gene expression
.
Cancers
.
2022
;
14
(
1
):
209
.
24.
Karacosta
LG
,
Anchang
B
,
Ignatiadis
N
,
Kimmey
SC
,
Benson
JA
,
Shrager
JB
.
Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution
.
Nat Commun
.
2019
;
10
(
1
):
5587
.
25.
Voon
DC
,
Huang
RY
,
Jackson
RA
,
Thiery
JP
.
The EMT spectrum and therapeutic opportunities
.
Mol Oncol
.
2017
;
11
(
7
):
878
91
.
26.
Cheng
C
,
Wang
J
,
Xu
P
,
Zhang
K
,
Xin
Z
,
Zhao
H
.
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer
.
Nat Cancer
.
2022
;
3
(
5
):
565
80
.
27.
Raymond
JH
,
Aktary
Z
,
Larue
L
,
Delmas
V
.
Targeting GPCRs and their signaling as a therapeutic option in melanoma
.
Cancers
.
2022
;
14
(
3
):
706
.
28.
Lengrand
J
,
Pastushenko
I
,
Vanuytven
S
,
Song
Y
,
Venet
D
,
Sarate
RM
.
Pharmacological targeting of netrin-1 inhibits EMT in cancer
.
Nature
.
2023
;
620
(
7973
):
402
8
.
29.
Bar-Hai
N
,
Ishay-Ronen
D
.
Engaging plasticity: differentiation therapy in solid tumors
.
Front Pharmacol
.
2022
;
13
:
944773
.
30.
Wright
BA
,
Kvansakul
M
,
Schierwater
B
,
Humbert
PO
.
Cell polarity signalling at the birth of multicellularity: what can we learn from the first animals
.
Front Cell Dev Biol
.
2022
;
10
:
1024489
.
31.
Brunet
T
,
Booth
DS
.
Cell polarity in the protist-to-animal transition
.
Curr Top Dev Biol
.
2023
;
154
:
1
36
.
32.
Pradeu
T
,
Daignan-Fornier
B
,
Ewald
A
,
Germain
PL
,
Okasha
S
,
Plutynski
A
.
Reuniting philosophy and science to advance cancer research
.
Biol Rev Camb Philos Soc
.
2023
;
98
(
5
):
1668
86
.
You do not currently have access to this content.