The rabbit eye has been used experimentally in research in vision and ophthalmology. However, there is little information about postnatal growth. The purpose of this study was to determine growth patterns of the rabbit globe from birth to young adult status focusing in particular on the fibrous outer tunic of the globe, the sclera. Eyes of both sexes of New Zealand White rabbits were examined on postnatal days 1, 7, 14, 28, 42 and 56. Axial length, equatorial diameter and corneal diameter were measured using a digital caliper. Plastic-embedded tissue was used to quantify scleral thickness and cellular density at anterior, equatorial and posterior sites. Axial length increased 230% between postnatal days 1 and 56. The rate of growth was not linear and revealed two peaks. The first peak occurred between postnatal days 1–7, and the second between days 14–28. Eye opening occurred on days 9–11. Sex differences were seen, with the male eye being larger (p = 0.00001). Surface area measurements of sclera and cornea revealed that the sclera occupies approximately 5/6 of the outer surface of the globe and the cornea 1/6. Scleral thickness increased from day 1 to day 42 (70–155 µm at the equator) while fibroblast density was found to decrease (0.32 to 0.05 cells/µm2). The results suggested that eye opening precedes a unique increase in the rate of eye growth and visual processes may be playing a role in modulating the growth pattern between days 14 and 28.

Andre, J.C., A. Haddad, R.S. Fife, G. Pelletier (1992) Morphologic and molecular changes during the postnatal development of the rabbit vitreous. Exp Eye Res 55/1:65–71.
Beyer, W.H. (1987) CRC Standard Mathematical Tables, ed 28. Boca Raton, CRC Press, p 131.
Bozkir, G., M. Bozkir, H. Dogan, K. Ayean, B. Guler (1997) Measurements of axial length and radius of corneal curvature in the rabbit eye. Acta Med Okayama 51/1:9–11.
Cintron, C., H.I. Covington, J.D. Gregory (1988) Organ culture of rabbit cornea: Morphological analyses. Curr Eyes Res 7:303–312.
Clum, N.J. (1991) Proximate mechanisms of sexual size dimorphism of the boat-tailed grackle (Quiscalus major); PhD thesis Cornell University, Ithaca.
Goedbloed, J.F. (1997) Embryonic and postnatal growth of rat and mouse. V. Prenatal growth of organs and tissues, general principles: Allometric growth, absence of growth, and the genetic regulation of the growth process. Acta Anat (Basel) 98:162–182.
Graham, B., S.J. Judge (1999) Normal development of refractive state and ocular component dimensions in the marmoset (Callithrix jacchus). Vision Res 39/2:177–187.
Harris J.W., H. Stocker (1998) Spherical Segment (Spherical Cap); in Handbook of Mathematics and Computational Science. New York, Springer, p 107.
Hilbert, D., S. Cohn-Vossen (1999) Geometry and the Imagination. New York, Chelsea, p 10.
Honda, S., S. Fujii, Y. Sekiya, M. Yamamoto (1996) Retinal control on the axial length mediated by transforming growth factor-beta in chick eye. Invest Ophthalmol Vis Sci 37:2519–2526.
Kugelberg, U., C. Zetterstrom, B. Lundgren, S. Syren-Nordqvist (1996) Eye growth in the aphakic newborn rabbit. J Cataract Refract Surg 22:337–341.
Kugelberg, U., C. Zetterstorm, B. Lundgren, S. Syren-Nordgvist (1997) Intraocular lens thickness and ocular growth in newborn rabbits. Acta Ophthalmol Scand 75/3:272–274.
Langenbach, G.E., W.A. Weijs (1990) Growth patterns of the rabbit masticatory muscles. J Dent Res 69/1:20–25.
Lilja, C. (1983) A comparative study of postnatal growth and organ development in some species of birds. Growth 47:317–339.
Liu, J.H., H. Farid (1998) Twenty-four-hour change in axial length in the rabbit eye. Invest Ophthalmol Vis Sci 39:2796–2799.
Marzani, D., J. Wallman (1997) Growth of the two layers of the chick sclera is modulated reciprocally by visual conditions. Invest Ophthalmol Vis Sci 38:1726–1739.
Murphy, C.J., T.J. Kern, H.C. Howland (1992) Refractive state, corneal curvature, accommodative range and ocular anatomy of the Asian elephant (Elephas maximus). Vision Res 32:2013–2021.
Naumann, G.O.H., D.J. Apple (1986) Pathology of the Eye. General Anatomy and Development of the Eye: Techniques of Investigation; Pathology of the Eye. New York, Springer chap 1, pp 1–18.
Nickla, D.L., J.A. Rada, J. Wallman (1999) Isolated chick sclera shows a circadian rhythm in proteoglycan synthesis perhaps associated with the rhythm in ocular elongation. J Comp Physiol 185/1:81–90.
Olsen, T.W., S.Y. Aaberg, D.H. Geroski, H.F. Edelhauser (1998) Human sclera: Thickness and surface area. Am J Ophthalmol 125/2:237–241.
Patel, S., J. McLaren, D. Hodge, W. Bourne (2001) Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo. Invest Ophthalmol Vis Sci 42:333–339.
Phadmanabhan, R., S. Singh (1978) A quantitative assessment of post-natal development in CF rats. Acta Anat (Basel) 102:300–307.
Raviola, E., T.N. Wiesel (1986) An animal model of myopia. N Engl J Med 312:1609–1615.
Ricklefs, R.E. (1968) Patterns of growth in birds. Ibis 110:419–451.
Schultes, G. (1991) Quantitative analysis of the postnatal axon growth in the dorsal funiculus of rats. Acta Anat (Basel) 140:85–96.
Siegwart, J.T. Jr., T.T. Norton (1999) Regulation of the mechanical properties of tree shrew sclera by the visual environment. Vision Res 39:387–407.
Stockdale, F.E., J.B. Miller (1987) The cellular basis of myosin heavy chain isoform expression during development of avian skeletal muscle. Dev Biol 123:1–9.
Teather, K.L. (1987) Intersexual differences in food consumption by handreared great-tailed grackle (Quiscalus mexicans) nestlings. Auk 104:635–639.
Tokoro, T., M. Funata, Y. Akazawa (1990) Influence of intraocular pressure on axial elongation. J Ocul Pharmacol 6/4:285–291.
Torczynski, E. (1982) Sclera; in Jakobiec, F.A. (ed): Ocular Anatomy, Embryology and Teratology. London, Harper & Row, chap 19, pp 587–599.
Wilson, J.R., A. Fernandes, C.V. Chandler, M. Tigges, R.G. Boothe, J.A. Gammon (1987) Abnormal development of the axial length of aphakic monkey eyes. Invest Ophthalmol Vis Sci 28:2096–2099.
Yamada, H., H. Obata, Y. Kaji, H. Yamashita (1999) Expression of transforming growth factor-beta superfamily receptors in developing rat eyes. Jpn J Ophthalmol 43/4:290–294.
Zhou, G., R.W. Williams (1999) Mouse models for the analysis of myopia: An analysis of variation in eye size of adult mice. Optom Vis Sci 76:408–418.
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