... tumors revealed the simultaneous presence of BRCA mutation and microsatellite instability (MSI)-high status. BRCA mutations have been reported in 13% of castration-resistant prostate cancer (CRPC) patients, and 3.1% of prostate cancer cases are MSI-high/mismatch repair deficient. Case Presentation: A 71...

... implies that deficiency mismatch repair proteins inducing microsatellite instability are considered one of the potential drivers of this disease. Hence, we report a stomach MiNEN with MMR protein loss. An admitted 60-year-old woman complained of epigastric pain. The pathological analysis of the gastro...

... microsatellite instability-high PDAC who had a prolonged response to single-agent pembrolizumab for almost 3 years. [email protected] 2 08 2021 22 08 2021 27 9 2021 © 2021 The Author(s). Published by S. Karger AG, Basel 2021 Open Access License / Drug Dosage / Disclaimer...

...Deepak Ravindranathan; Greta Anne Russler; Lauren Yantorni; Leylah M. Drusbosky; Mehmet Asim Bilen Pembrolizumab has been approved by the US Food and Drug Administration for the treatment of metastatic or unresectable solid tumors that are microsatellite instability-high (MSI-H) or mismatch repair...

.... Pathologically, the surgical margin was negative. The tumor was negative for microsatellite instability (MSI). Considering her age, she has remained under careful observation with neither systemic treatment nor adjuvant radiation. The only standard therapy for RIAS currently available is complete resection...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endometrial cancer Mismatch repair proteins Checkpoint inhibitors Microsatellite instability Hereditary nonpolyposis colorectal cancer syndrome Endometrial...

... for tumor, and no lymphovascular or perineural invasion was noted. None of the 14 resected pericolonic lymph nodes was positive for malignancy. Hence, she was staged as pT3, pN0, pMx-stage IIA. The appendix was not involved. Microsatellite instability testing showed the preservation of MLH1, PMS2, MSH2...