...Yoshikazu Toshima; Keiki Yokoo; Koki Kamata; Takayuki Nagao; Satoshi Ota; Gen Yamada; Hirofumi Chiba Introduction: Immune-checkpoint inhibitors, such as pembrolizumab, have been used for non-small cell lung cancer treatment but are often associated with immune-related adverse events (irAEs). Case...

...Sorane Maezumi; Takuro Okada; Takuma Kishida; Yasuo Ogawa; Kiyoaki Tsukahara Introduction: Immune-related adverse events (irAEs) from nivolumab can affect any organ, but renal impairment is less common than effects on other organs. We encountered a case in which a renal irAE was difficult...

... inhibition Non-small cell lung carcinoma Immune-related adverse event Case report Sjögren’s syndrome (SS) is a systemic auto-immune disease that mainly affects the exocrine glands which leads to sicca syndrome: dryness of the main mucosal surfaces, such as the mouth, eyes, nose, pharynx, larynx...

...Helena J. Janse van Rensburg; Pavlina Spiliopoulou; Anas Makhzoum; Brian D. Healy Immune checkpoint inhibitors (ICIs) have emerged as a novel class of anti-neoplastic agent in oncology. Their integration into practice has been accompanied by “immune-related adverse events” (irAEs) wherein off...

...Tomoaki Nakamura; Ryosuke Imai; Naoki Nishimura In this report, we present a case of nonsmall-cell lung cancer with anaphylaxis after 41 courses of pembrolizumab along with adrenal insufficiency as an immune-related adverse event (irAE). A 73-year-old man with no allergic disease started...

...Anna Carbó-Bagué; Roser Fort-Culillas; Helena Pla-Juher; Jordi Rubió-Casadevall Autoimmune haemolytic anaemia (AIHA) is a rare immune-related adverse event and appears to be more common with anti-PD1/PDL1 than anti-CTLA4. Little is known about the safety of re-treating with anti-PD1/PDL1...

...Yumi Kambayashi; Taku Fujimura; Hiroshi Kuroda; Atsushi Otsuka; Hiroyuki Irie; Setsuya Aiba Immune checkpoint inhibitors (ICIs) significantly prolong survival in patients with metastatic melanoma but can lead to serious immune-related adverse events. In this report, we described a case of atypical...

...Anastasie M. Dunn-Pirio; Suma Shah; Christopher Eckstein Recently, immune checkpoint inhibitors have revolutionized cancer care by enhancing anti-tumor immunity. However, by virtue of stimulating the immune system, they can lead to immune-related adverse events (irAEs). Neurologic irAEs...

...Keisuke Imafuku; Koji Yoshino; Kei Yamaguchi; Satoshi Tsuboi; Kuniaki Ohara; Hiroo Hata Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nivolumab Ipilimumab Metastatic melanoma Immune-related adverse event Immune checkpoint inhibitors Case Report Case Rep Oncol 2016;9:644 649 DOI: 10.1159/000450974...