..., instructions or products referred to in the content or advertisements. 2024 Clear cell renal cell carcinoma Targeted therapies Immune checkpoint inhibitors Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of kidney cancer in adults, representing a significant clinical...

...-colony-stimulating factor Immune checkpoint inhibitors Lung cancer Pembrolizumab Steroid Granulocyte-colony-stimulating factor (G-CSF)-producing tumors induce leukocytosis and inflammation and have been reported in various cancers, such as lung cancer, liver cancer, and stomach cancer [ 1...

.... 2024 Leiomyosarcoma Soft tissue sarcoma Immune checkpoint inhibitors Immunotherapy Programmed death 1 Pembrolizumab Ascorbate Vitamin C Leiomyosarcoma (LMS) makes up approximately 25% of soft tissue sarcomas, a rare heterogeneous group of neoplasms derived from mesenchymal stem...

... Pneumonia Small cell lung carcinoma Immune checkpoint inhibitors Programmed death ligand 1 Durvalumab Small cell lung cancer (SCLC) accounts for approximately 14% of all lung cancers [ 1, 2 ]. Immune checkpoint inhibitors (ICIs) in combination with chemotherapy have become the new standard...

...Melina Yerolatsite; Nanteznta Torounidou; Anna-Lea Amylidi; Fani Kapoulitsa; Eleftherios Kampletsas; George Zarkavelis; Davide Mauri Introduction: The introduction of immune checkpoint inhibitors (ICIs) has opened a new chapter in cancer treatment. Nevertheless, their use may result in immune...

...Marine Georgery; Aurélie Ram; Tess Van Meerhaeghe; Annie Drowart; Anne-Lorraine Clause; Lissandra Dal Lago; Héloïse Rouvière Introduction: The use of immune checkpoint inhibitors has revolutionized cancer treatment, and their application to older people is considered safe by the scientific...

... and pegfilgrastim. The patient developed fever and right ear pain 12 days after pegfilgrastim administration and was diagnosed with aortitis by contrast-enhanced computed tomography 5 days later. Because the patient had already been administered the immune checkpoint inhibitor and had a history of hepatitis B...

...Dennis Hoch; Manuela Rabaglio; Tobias Grob; Michael von Gunten; Jörg Beyer; Dilara Akhoundova Mismatch repair-deficient (dMMR) prostate cancer (PCa) is a rare (1–5%) but highly actionable molecular subgroup of PCa, vulnerable to immune checkpoint inhibitors. Our case of sporadic dMMR PCa due...

... to in the content or advertisements. 2023 Cutaneous squamous cell carcinoma Cutaneous oncology Dermatology Metastatic cutaneous squamous cell carcinoma Immunotherapy Immunotoxicities Immune checkpoint inhibitors Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer...

... for the persistence of cancer immunity during long-term treatment with immune checkpoint inhibitors and the potential for further activation. [email protected] 1 07 2023 18 08 2023 13 09 2023 © 2023 The Author(s). Published by S. Karger AG, Basel Open Access License / Drug Dosage...

...Ana Paric; Dragana Karan-Krizanac; Ivan Saric; Semir Vranic Colorectal cancer (CRC) is the third leading cause of mortality worldwide. The Food and Drug Administration recently designated pembrolizumab, an immune checkpoint inhibitor (ICI) against a programmed death-1 receptor, as a breakthrough...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immune checkpoint inhibitors Immune-related adverse event Autoimmune haemolytic anaemia Nivolumab Ipilimumab...

... due to immune checkpoint inhibitors. A 76-year-old man with c-stage IIIA squamous cell carcinoma of the lung received maintenance durvalumab therapy after chemoradiotherapy. He developed dyspnea and malaise after 11 cycles of durvalumab. Chest computed tomography showed rapidly spreading bilateral...

...Thuridur Thorsteinsdottir; Teje Løitegård; Henrik Mikael Reims; Alina Carmen Porojnicu The use of immune checkpoint inhibitors has dramatically improved the chance of surviving malignant melanomas; however, the effect comes at the cost of toxicities that are difficult to predict. Immune-mediated...

...Walid Shalata; Nir Peled; Itzhak Gabizon; Omar Abu Saleh; Waleed Kian; Alexander Yakobson In the present case report, we aimed to describe 2 cases of myocarditis occurring as serious adverse effects of immune checkpoint inhibitors (ICIs) administered as treatment for metastatic melanoma. We...

... authors contributed to this manuscript and approved the final manuscript. References 1. Hryniewicki   AT , Wang   C , Shatsky   RA , Coyne   CJ . Management of immune checkpoint inhibitor toxicities: a review and clinical guideline for emergency physicians . J Emerg Med . 2018...

...Nikhil Agrawal; Arjun Khunger; Pankit Vachhani; Teresa A. Colvin; Alexander Hattoum; Edward Spangenthal; Anne B. Curtis; Grace K. Dy; Marc S. Ernstoff; Igor Puzanov The development of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced stage cancers...

... disease Pseudoprogression Radiotherapy Nivolumab Immune checkpoint inhibitors Nowadays, immune checkpoint inhibitors are used to treat various types of tumors [ 1-3 ]. The ATTRACTION-2 study found that nivolumab administered to patients who were previously treated for advanced gastric cancer...

... recommendations for this group rely on data from the similar but more common small-cell carcinoma of the lungs. Immune checkpoint inhibitors are being investigated for the treatment of metastatic small-cell lung cancer with positive outcome. We applied the experience from these studies to a case of metastatic...

... to in the content or advertisements. Pembrolizumab Immune checkpoint inhibitors Skin toxicity The important connection between immunology and oncology has been long understood; however, the therapeutic implications were previously limited to the use of cytokines in the diseases such as melanoma...