...Kacper Koczyk; Arkadiusz Nowak; Marcin M. Machnicki; Łukasz Zdzisław Michałowski; Edyta Maj; Tomasz Stoklosa; Przemysław Kunert Introduction: Intramedullary glioblastoma is a rare entity comprising 1.4–9% of spinal gliomas. Spinal cord radiation-induced gliomas are unique, with only 13 cases...

... months after initial presentation, surprisingly revealed a second primary cancer diagnosis of glioblastoma (GB). Unfortunately, despite revision of systemic therapeutic strategy, the patient continued to progress through treatment and ultimately died 16 months after the initial diagnosis. Conclusion...

...Jacqueline Boyle; William Miller; Andrew Tsung Introduction: We present the case of a 58-year-old female with Branchiootorenal (BOR) syndrome who was diagnosed with glioblastoma (GBM). A relationship between BOR syndrome and GBM has not previously been reported, prompting a literature review...

... in individuals with newly diagnosed glioblastoma (GBM). Lomustine (CCNU) is frequently used as monotherapy or concomitant with other chemotherapy regimens as second-line treatment for recurrent GBM. Case Presentation: We report a 59-year-old female patient diagnosed with MGMT -promoter methylated, isocitrate...

... , . Comparison of cancer prevalence in patients with neurofibromatosis type 1 at an academic cancer center vs in the general population from 1985 to 2020 . JAMA Netw Open . 2021 ; 4 ( 3 ): e210945 . Sarcoma High-grade glioma Glioblastoma Radiation Complication Secondary cancer Gliomas...

...Kosuke Karatsu; Ryota Tamura; Masahiro Yo; Hirotsugu Nogawa; Utaro Hino; Yohei Kitamura; Ryo Ueda; Masahiro Toda Introduction: Glioblastomas can manifest as multiple, simultaneous, noncontiguous lesions. We genetically analyzed multiple glioblastomas and discuss their etiological origins...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 COVID-19 Pandemic SARS-CoV-2 Glioma Glioblastoma Brain tumor The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus...

...Vasu Munjapara; Thatcher Heumann; Karisa C. Schreck; John M. Gross; Carlos Perez-Heydrich; Sachin K. Gujar; Charles G. Eberhart; Matthias Holdhoff Recent advancements in understanding the biology of glioblastomas (GBM) and increasing adoption of genomic sequencing in oncology practice have led...

...Mario Pirozzi; Marianna Caterino; Sergio Facchini; Alessia Zotta; Gaetana Messina; Raffaele Rauso; Antonello Sica; Donato Sciano; Gaetano Facchini; Michele Orditura; Teresa Somma; Francesco Maiuri; Paolo Cappabianca; Fortunato Ciardiello; Morena Fasano Glioblastoma multiforme (GBM) is one...

...Eric T. Wong; Justin Moore; Lauren Hertan; Erik J. Uhlmann The rapidity of glioblastoma progression can be exacerbated by impaired systemic immune surveillance. We describe an elderly woman with advanced 5q– myelodysplastic syndrome (MDS) associated with trilineage dysfunction in hematopoiesis. She...

... become the standard of care in the treatment of primary intracranial malignancies including anaplastic astrocytoma and glioblastoma multiforme (GBM) after several clinical trials demonstrated improved progression-free survival and overall survival [ 2 ]. Moreover, TMZ has shown good response rates...

...Gil Awada; Daphne Serruys; Julia Katharina Schwarze; Lien Van De Voorde; Johnny Duerinck; Bart Neyns Patients with neurofibromatosis type 1 (NF1) have an increased lifetime risk for the development of nervous system tumors, including high-grade gliomas (glioblastoma). NF1 is associated...

...Rohit Thummalapalli; Thatcher Heumann; Julie Stein; Sarah Khan; David S. Priemer; Amy S. Duffield; John Laterra; Rima Couzi; Michael Lim; Matthias Holdhoff Immune checkpoint inhibition (ICI)-based approaches have transformed the treatment landscape of numerous solid tumors. Glioblastoma (GBM...

... diagnosed with synchronous glioblastoma, epidermal growth factor receptor-mutated lung adenocarcinoma, and HER2-negative breast cancer metastases. The patient was treated with local therapies, including brain surgery and radiotherapy, lung surgery, and a bilateral mastectomy, as well as with targeted...

...Wouter O. van Seggelen; Filip Y. De Vos; Heike Röckmann; Marijke R. van Dijk; Joost J.C. Verhoeff Glioblastoma multiforme is the most frequent primary brain tumor. The clinical course of glioblastoma is almost invariably fatal. Combined chemo-irradiation with temozolomide is currently the standard...

...Tomoyuki Nakano; Kaoru Tamura; Yoji Tanaka; Motoki Inaji; Shihori Hayashi; Daisuke Kobayashi; Tadashi Nariai; Jun Toyohara; Kenji Ishii; Taketoshi Maehara Recently developed molecular targeted therapies such as bevacizumab (BEV; Avastin) therapy have therapeutic efficacy for glioblastoma. However...

...Mohamad Chehimi; Mathieu Boone; Cyril Chivot; Hervé Deramond; Jean-Marc Constans; Mony Chenda Ly; Bruno Chauffert There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could...

...Rodrigo Ramella Munhoz; Andrea Arvai Pereira Picarelli; Cristina Aparecida Troques Mitteldorf; Olavo Feher Leukopenia and selective CD4+ lymphopenia represent major adverse events associated with the use of temozolomide (TMZ), an oral alkylating agent incorporated in the treatment of glioblastoma...

... al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-996. 5. Wesseling P, Kros JM, Jeuken JWM: The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context. Diagn...

...Celina Bihan; Sylvain Foscolo; Mathieu Boone; Marie Blonski; Alexandre Coutte; Amélie Darlix; Patrick Beauchesne; Michel Lefranc; Veronique Lorgis; Luc Taillandier; Bruno Chauffert Unresectable glioblastomas with severe neurological impairment at diagnosis have a poor prognosis. The conventional...