... that denosumab induces intratumoral ossification in β-catenin positive GCTB. However, its effect on the complete resection of GCTB with extraskeletal lesions remains unclear. Case Presentation: A 45-year-old woman with a pathological fracture of the left distal femur was diagnosed with GCTB based on the biopsy...

... of the nasal cavity successfully treated with nivolu-mab, ipilimumab plus denosumab combination therapy. Fig. 1. CT scan before radiotherapy: local recurrence of melanoma, 36.80 × 26.78 mm in size, in the nasal cavity ( A ). MRI at 2 months after IMRT treatment: regression of the tumor ( B ). Fig. 1. CT...

... to dermatologists. Recent reports suggested that, since CD8+ T cells after the administration of ICIs increase the RANKL expression to induce an immunosuppressive tumor microenvironment in melanoma, denosumab might enhance the anti-tumor effects of immune checkpoint inhibitors, such as nivolumab and ipilimumab...

...) is expressed in cancers of apocrine origin, leading to immunosuppression at the tumor site, we hypothesized that targeting RANKL with denosumab might be useful for the treatment of PCAC. In this report, we describe a case with advanced PCAC on the scrotum successfully treated with systemic chemotherapy using...