...Brendan Coyne; Sanjeev Saravanakumar; Franco Murillo-Chavez; Nivedita Kharkongor Chengappa; Rida Ihsan; Bilal A. Chaudhry Introduction: Profuse diarrhea and abdominal discomfort are well-documented symptoms of patients with known colorectal cancer. It is much less common for these patients...

... Mixed neuroendocrine-non-neuroendocrine neoplasms Mixed epithelial endocrine neoplasms Case report Colorectal cancer The term mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) was redefined by the World Health Organization (WHO) in 2017 as the association of two types of components...

...Sydney Brooke Hoskins; Leslie Torgerson Introduction: Mutations of CHEK2 are usually inherited and have been implicated in breast cancers, colorectal cancers, thyroid cancers, kidney cancers, and prostate cancers. The CHEK2 gene codes for checkpoint kinase 2 protein which is an effector in the ATM...

...Masatsune Shibutani; Hideki Tanda; Tatsunari Fukuoka; Hiroaki Kasashima; Shinichiro Kashiwagi; Kiyoshi Maeda Introduction: Reexposure to anti-EGFR antibodies, such as a reintroduction or rechallenge with anti-EGFR antibodies, has attracted much attention in the field of metastatic colorectal cancer...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Circulating tumor DNA Methylation Liquid biopsy Hepatitis C virus Colorectal cancer False positive Minimal residual disease (MRD) assays, which can...

...Ana Paric; Dragana Karan-Krizanac; Ivan Saric; Semir Vranic Colorectal cancer (CRC) is the third leading cause of mortality worldwide. The Food and Drug Administration recently designated pembrolizumab, an immune checkpoint inhibitor (ICI) against a programmed death-1 receptor, as a breakthrough...

... with newly diagnosed metastatic colorectal cancer (CRC). We report a case in which ctDNA testing uncovered an actionable biomarker that was not detected by comprehensive genomic profiling of tumor tissue. An 81-year-old woman with a remote history of non-Hodgkin’s lymphoma presented with primary masses...

.... Colorectal cancer Cardiac metastasis Resection Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide. Over 1.8 million new cases occurred worldwide in 2020 [1]. CRC metastasizes to the lymph nodes, liver, or lungs as a usual distant metastasis. Based on autopsy studies...

...Landon Kozai; Kevin Benavente; Adham Obeidat; Jared Acoba Colorectal cancer (CRC) in pregnancy is rare and often presents at a late stage due to the masking of signs by pregnancy. A typical chemotherapeutic regimen for stage III and IV CRC comprised 5-Fluorouracil (5-FU) and oxaliplatin...

... reasons. Oncologists should note this type of recurrence to properly treat the patients with recurrent colorectal cancer. It was difficult for us to definitely determine the small intestinal focus as a primary small intestinal cancer or a metastatic tumor of the rectal cancer. PET/CT showed...

...Sheng-Yen Hsiao; Hong-Lin He; Teng-Song Weng; Cheng-Yao Lin; Chien-Ming Chao; Wen-Tsung Huang; Chao-Jung Tsao Anti-epithelial growth factor receptor or anti-vascular endothelial growth factor agents combined with chemotherapy were the standard of treatment for metastatic colorectal cancer (CRC...

...Sergey V. Orlov; Magaripa A. Urtenova; Maria A. Sviridenko; Denis V. Nesterov; Tatiana N. Sokolova; Evgeny N. Imyanitov Activating RAS mutations occur in more than a half of colorectal cancers (CRCs). RAS-mutated CRCs are notoriously difficult to treat given that they are characterized...

... colorectal cancer who underwent extended left colectomy. In the case of compromised vessel anatomy, it was decided to perform antiperistaltic cecorectal anastomosis. We present all clinical and intraoperative patient’s data, determining the surgical tactics, and short-term postoperative results...

... adenocarcinoma accompanied by lymph node metastases. Following surgery and adjuvant chemotherapy, computed tomography (CT) and carcinoembryonic antigen screening were negative. Two years later, CT demonstrated a liver lesion. Histologic and genetic analyses confirmed the diagnosis of metastatic colorectal cancer...

...Francisco Ibargüengoitia Ochoa; Gerardo Miranda Dévora; Leonardo Silva Lino; Cintia Sepulveda Rivera; Diego González Vázquez; Milagros Pérez Quintanilla Colorectal cancer during pregnancy is one of the less common neoplasms with an incidence of 0.8 in 100,000 pregnancies. Primary colonic signet...

...Takehito Ehara; Masato Kitazawa; Nao Hondo; Shugo Takahata; Yuta Yamamoto; Makoto Koyama; Motohiro Okumura; Satoshi Nakamura; Shigeo Tokumaru; Futoshi Muranaka; Yusuke Miyagawa; Yuji Soejima Disseminated carcinomatosis of the bone marrow (DCBM) in colorectal cancer is an extremely rare complication...

...Chikako Funasaka; Yusuke Kanemasa; Tatsu Shimoyama; Akihito Ohta; Yasushi Omuro Fluorouracil plus oxaliplatin (L-OHP) (FOLFOX) plus bevacizumab (BV) therapy is commonly administered to patients with metastatic colorectal cancer. However, few reports have described L-OHP therapy in hemodialysis...

... man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double contour of the glomerular basement membrane, which indicated a diagnosis...

...Masatsune Shibutani; Kiyoshi Maeda; Hisashi Nagahara; Tatsunari Fukuoka; Yasuhito Iseki; Shinji Matsutani; En Wang; Kosei Hirakawa; Masaichi Ohira With advances in new cytotoxic drugs and molecular-targeted drugs, the prognosis of patients with metastatic colorectal cancer (mCRC) has improved...

...Irene E.G. van Hellemond; Annemarie M. Thijs; Geert-Jan Creemers Capecitabine is an oral fluoropyrimidine used as adjuvant and palliative chemotherapy in patients with colorectal cancer. Diarrhea is a well-known side effect of capecitabine and 5-fluorouracil agents. We present a case with terminal...