...Akihiro Tsukaguchi; Seigo Minami; Hironao Yasuoka; Yoshihiro Kin Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor (TKI), inhibits multiple kinase pathways and is a promising anti-tumor agent for various solid tumors, including lung cancer. Herein, we report a patient...

... during blood work for other reasons or enlarged spleen. The diagnosis is based on WHO criteria that require the demonstration of Philadelphia chromosome. Typically, JAK2 mutation is not found in BCR-ABL1 -positive MPN (CML). Most patients with CML are JAK2 negative. It is rare for CML Philadelphia...

...Camilla Zanaglio; Simona Bernardi; Lisa Gandolfi; Mirko Farina; Federica Re; Nicola Polverelli; Tatiana Zollner; Alessandro Turra; Enrico Morello; Michele Malagola; Domenico Russo Real-time quantitative PCR (RT-qPCR) is the gold standard to quantify the BCR-ABL1 transcript for molecular response...

...-lineage markers including CD13 and CD33, as well as B-cell-lineage markers. Minor bcr-abl1 mRNA was detected by real-time quantitative polymerase chain reaction. Chromosomal abnormality monosomy 7 was also observed, in addition to Ph1. Despite treatment difficulties that were anticipated based...