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First page of Long-term survival for locally advanced adenosquamous ASC colon cancer in ulcerative colitis: Case report

Adenosquamous carcinoma (ASC) of the colon is an exceedingly rare and aggressive subtype, with limited data available on long-term survival, particularly among patients with ulcerative colitis (UC). We present the case of a 39-year-old male with a nine-year history of UC who experienced severe anemia and hematochezia. Imaging and histopathological analysis confirmed a diagnosis of stage IIIB ASC of the right colon. The patient underwent total colectomy followed by adjuvant chemotherapy (XELOX), ileoanal pouch reconstruction, and stoma closure. After 56 months of follow-up, he remains disease-free with good pouch function. This case underscores the need for further research into UC-associated carcinogenesis and the development of ASC-specific treatment strategies

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2025
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