Article PDF first page preview

First page of Blood Pressure Variability in Older Patients with Chronic Kidney Disease

Introduction: An increased blood pressure variability (BPV) is associated with a high risk of cardiovascular events in the general population. This concept was scarcely tested in patients with chronic kidney disease. We investigated the behavior of BPV parameters in a large cohort of older patients with CKD. Methods: This retrospective cohort study included patients ≥ 75 years old with eGFR ≤ 60 ml/min. Three systolic and diastolic consecutive blood pressure (BP) measurements were obtained automatically per visit (short-term - 3 consecutive measurements) and across visits (long-term - across visits). We calculated: 1) standard deviation (SD); 2) coefficient of variation (SD divided by the BP average) and 3) variability independent of the mean (VIM). For each BPV parameter, patients were divided into four quartiles. Results: We included 1,063 patients (17,363 measurements). For short-BPV: the higher systolic BPV (SD and VIM) was associated with older age, a lower proportion of males and a higher proportion of patients with pulse pressure (PP) > 40 mmHg. Higher diastolic BPV (SD and VIM) was associated with lower body mass index, lower eGFR and a higher proportion of PP > 40 mmHg (for SD). Bland-Altman plots revealed comparable results between short- and long-term BPV. Conclusion: A higher BPV was associated with reduced renal function in older patients with chronic kidney disease. Our study also suggests that short- and long-term BPV can be used with similar results. Further studies are needed to confirm the association between BPV and outcomes and understand the physiological mechanisms underlying this correlation.

Journal Section:
Research Article
This content is only available via PDF.
The Author(s). Published by S. Karger AG, Basel
Open Access License / Drug Dosage / Disclaimer
This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
2025
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License .
Attribution-NonCommercial