Despite the availability of blood pressure (BP)-lowering medications and dietary education, hypertension is still poorly controlled in the chronic kidney disease (CKD) population. As glomerular filtration rate declines, the number of medications required to achieve BP targets increases, which may lead to reduced patient adherence and therapeutic inertia by the clinician. Home BP monitoring (HBPM) has emerged as a means of improving diagnostic accuracy, risk stratification, patient adherence, and therapeutic intervention. The definition of hypertension by HBPM is an average BP >135/85 mm Hg. Twelve readings over the course of 3-5 days are sufficient for clinical decision making. Diagnostic accuracy is especially important in the CKD population as approximately half of these patients have either white coat hypertension or masked hypertension. Preliminary data suggest that HBPM outperforms office BP monitoring in predicting progression to end-stage renal disease or death. When combined with additional support such as telemonitoring, medication titration, or behavioral therapy, HBPM results in a sustained improvement in BP control. HBPM must be adapted to provide information on the phenomena of nondipping (absence of nocturnal fall in BP) and reverse dipping (paradoxical increase in BP at night). These diurnal patterns are more prevalent in the CKD population and are important cardiovascular risk factors. Ambulatory BP monitoring provides nocturnal BP readings and unlike HBPM may be reimbursed by Medicare when certain criteria are met. Further studies are needed to determine whether HBPM is cost-effective in the current US healthcare system.

1.
Chobanian AV, Bakris GL, Black HR, et al: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003;289:2560-2572.
2.
James PA, Oparil S, Carter BL, et al: 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-520.
3.
Taler SJ, Agarwal R, Bakris GL, et al: KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD. Am J Kidney Dis 2013;62:201-213.
4.
Verberk W, Kroon A, Kessels A, de Leeuw P: Home blood pressure measurement: a systematic review. J Am Coll Cardiol 2005;46:743-751.
5.
Tsuji I, Imai Y, Nagai K, et al: Proposal of reference values for home blood pressure measurement: prognostic criteria based on a prospective observation of the general population in Ohasama, Japan. Am J Hypertens 1997;10:409-418.
6.
Niiranen TJ, Asayama K, Thijs L, et al: Outcome-driven thresholds for home blood pressure measurement: international database of home blood pressure in relation to cardiovascular outcome. Hypertension 2013;61:27-34.
7.
Parati G, Stergiou G, Asmar R, et al: European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring. J Hypertens 2008;26:1505-1526.
8.
Wilson P: Established risk factors and coronary artery disease: the Framingham Study. Am J Hypertens 1994;7:7S-12S.
9.
Buckalew VJ, Berg R, Wang S, et al: Prevalence of hypertension in 1,795 subjects with chronic renal disease: the modification of diet in renal disease study baseline cohort. Modification of Diet in Renal Disease Study Group. Am J Kidney Dis 1996;28:811-821.
10.
Stergiou GS, Karpettas N, Kapoyiannis A, Stefanidis CJ, Vazeou A: Home blood pressure monitoring in children and adolescents: a systematic review. J Hypertens 2009;27:1941-1947.
11.
Ohkubo T, Imai Y, Tsuji I, et al: Home blood pressure measurement has a stronger predictive power for mortality than does screening blood pressure measurement: a population-based observation in Ohasama, Japan. J Hypertens 1998;16:971-975.
12.
Sega R, Facchetti R, Bombelli M, et al: Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Circulation 2005;111:1777-1783.
13.
Drawz P, Abdalla M, Rahman M: Blood pressure measurement: clinic, home, ambulatory, and beyond. Am J Kidney Dis 2012;60:449-462.
14.
Stergiou GS, Asayama K, Thijs L, et al: Prognosis of white-coat and masked hypertension: international database of home blood pressure in relation to cardiovascular outcome. Hypertension 2014;63:675-682.
15.
Niiranen T, Thijs L, Asayama K, et al: The International Database of Home blood pressure in relation to Cardiovascular Outcome (IDHOCO): moving from baseline characteristics to research. Hypertens Res 2012;35:1072-1079.
16.
Peralta C, Hicks L, Chertow G, et al: Control of hypertension in adults with chronic kidney disease in the United States. Hypertension 2005;45:1119-1124.
17.
Andersen M, Khawandi W, Agarwal R: Home blood pressure monitoring in CKD. Am J Kidney Dis 2005;45:994-1001.
18.
Gabbai F, Rahman M, Hu B, et al: Relationship between ambulatory BP and clinical outcomes in patients with hypertensive CKD. Clin J Am Soc Nephrol 2012;7:1770-1776.
19.
Hänninen M, Niiranen T, Puukka P, Johansson J, Jula A: Prognostic significance of masked and white-coat hypertension in the general population: the Finn-Home Study. J Hypertens 2012;30:705-712.
20.
Mule G, Caimi G, Cottone S: Value of home blood pressures as predictor of target organ damage in mild arterial hypertension. J Cardiovasc Risk 2002;9:123-129.
21.
Agarwal R, Andersen M: Prognostic importance of clinic and home blood pressure recordings in patients with chronic kidney disease. Kidney Int 2006;69:406-411.
22.
Romero MJ: Home blood pressure variability: a new target to monitor in chronic kidney disease patients with low eGFR? Hypertens Res 2013;36:673-675.
23.
Nishimura M, Kato Y, Tanaka T, et al: Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria. Hypertens Res 2013;36:705-710.
24.
Okada T, Matsumoto H, Nagaoka Y, Nakao T: Association of home blood pressure variability with progression of chronic kidney disease. Blood Press Monit 2012;17:1-7.
25.
Cohen D, Younghong H, Townsend R: Ambulatory blood pressure in chronic kidney disease. Curr Hypertens Rep 2013;15:160-166.
26.
Wolf J, Hering D, Narkiewicz K: Non-dipping pattern of hypertension and obstructive sleep apnea syndrome. Hypertens Res 2010;33:867-871.
27.
Doherty L, Kiely J, Swan V, McNicholas W: Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome. Chest 2005;127:2076-2084.
28.
Chonan K, Kikuya M, Araki T, et al: Device for the self-measurement of blood pressure that can monitor blood pressure during sleep. Blood Press Monit 2001;6:203-205.
29.
Sabate E: Adherence to Long-Term Therapies: Evidence for Action. Geneva, World Health Organization, 2003.
30.
Johnson A, Taylor D, Sackett D, et al: Self-recording of blood pressure in the management of hypertension. Can Med Assoc J 1978;119:1034-1039.
31.
Márquez-Contreras E, Martell-Claros N, Gil-Guillén V, et al; Compliance Group of the Spanish Society of Hypertension (SEE): Efficacy of a home blood pressure monitoring programme on therapeutic compliance in hypertension: the EAPACUM-HTA study. J Hypertens 2006;24:169-175.
32.
Den Hond E, Staessen JA, Celis H, et al; Treatment of Hypertension Based on Home or Office Blood Pressure (THOP) Trial Investigators: Antihypertensive treatment based on home or office blood pressure - the THOP trial. Blood Press Monit 2004;9:311-314.
33.
Verberk W, Kroon A, Kessels A, et al: Home versus Office blood pressure Measurements: Reduction of Unnecessary treatment Study: rationale and study design of the HOMERUS trial. Blood Press 2003;12:326-333.
34.
McManus R, Mant J, Bray E, et al: Telemonitoring and self-management in the control of hypertension (TASMINH2): a randomised controlled trial. Lancet 2010;376:163-172.
35.
Bosworth H, Powers B, Olsen M, et al: Home blood pressure management and improved blood pressure control: results from a randomized controlled trial. Arch Intern Med 2011;171:1173-1180.
36.
Margolis KL, Asche SE, Bergdall AR, et al: Effect of home blood pressure telemonitoring and pharmacist management on blood pressure control: a cluster randomized clinical trial. JAMA 2013;310:46-56.
37.
Uhlig K, Patel K, Ip S, Kitsios G, Balk E: Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis. Ann Intern Med 2013;159:185-194.
38.
Blood pressure monitors validated for home use. 2012. www.bhsoc.org (accessed January 14, 2014).
39.
Clinically validated home blood pressure monitors. 2008. www.bloodpressureuk.org (accessed January 14, 2014).
40.
Lovibond K, Jowett S, Barton P, et al: Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. Lancet 2011;378:1219-1230.
41.
Fukunaga H, Ohkubo T, Kobayashi M, et al: Cost-effectiveness of the introduction of home blood pressure measurement in patients with office hypertension. J Hypertens 2008;26:685-690.
42.
Pickering TG, Miller NH, Ogedegbe G, et al: Call to action on use and reimbursement for home blood pressure monitoring: a joint scientific statement from the American Heart Association, American Society Of Hypertension, and Preventive Cardiovascular Nurses Association. Hypertension 2008;52:10-29.
43.
Tunis S, Kendall P, Londner M, Whyte J: Medicare Coverage Policy - Decisions: Ambulatory Blood Pressure Monitoring (#CAG-00067N): Decision Memorandum. Washington DC, 2001.
44.
Sphygmomanometers for self-measurement of blood pressure. 2013. www.dableeducational.org (accessed January 14, 2014).
45.
Stergiou G, Skeva I, Zourbaki A, Mountokalakis T: Self-monitoring of blood pressure at home: how many measurements are needed? J Hypertens 1998;16:725-731.
46.
Thompson A, Eguchi K, Reznik M, Shah S, Pickering T: Validation of an oscillometric home blood pressure monitor in an end-stage renal disease population and the effect of arterial stiffness on its accuracy. Blood Press Monit 2007;12:227-232.
47.
Rahman M, Griffin V, Kumar A, Manzoor F, Wright JJ, Smith M: A comparison of standardized versus ‘usual' blood pressure measurements in hemodialysis patients. Am J Kidney Dis 2002;39:1226-1230.
48.
Levin N, Kotanko P, Eckardt K, et al: Blood pressure in chronic kidney disease stage 5D - report from a Kidney Disease: Improving Global Outcomes controversies conference. Kidney Int 2010;77:273-284.
49.
Tentori F, Hunt W, Rohrscheib M, et al: Which targets in clinical practice guidelines are associated with improved survival in a large dialysis organization? J Am Soc Nephrol 2007;18:2377.
50.
Alborzi P, Patel N, Agarwal R: Home blood pressures are of greater prognostic value than hemodialysis unit recordings. Clin J Am Soc Nephrol 2007;2:1228-1234.
51.
Agarwal R, Satyan S, Alborzi P: Home blood pressure measurements for managing hypertension in hemodialysis patients. Am J Nephrol 2009;30:126-134.
52.
Kauric-Klein Z, Artinian N: Improving blood pressure control in hypertensive hemodialysis patients. CANNT J 2007;17:24-28, 31-36.
53.
Wang M, Tseng C, Tsai W, Huang J: Blood pressure and left ventricular hypertrophy in patients on different peritoneal dialysis regimens. Perit Dial Int 2001;21:36-42.
54.
Mangray M, Vella J: Hypertension after kidney transplant. Am J Kidney Dis 2011;57:331.
55.
Kasiske B, Anjum S, Shah R, et al: Hypertension after kidney transplantation. Am J Kidney Dis 2004;43:1071-1081.
56.
Agena F, Prado Edos S, Souza P, et al: Home blood pressure (BP) monitoring in kidney transplant recipients is more adequate to monitor BP than office BP. Nephrol Dial Transplant 2011;26:3745-3749.
57.
Asayama K, Ohkubo T, Metoki H, et al: Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure. Hypertens Res 2012;35:1102-1110.
58.
Okada T, Nakao T, Matsumoto H, et al: Prognostic significance of home blood pressure control on renal and cardiovascular outcomes in elderly patients with chronic kidney disease. Hypertens Res 2009;32:1123-1129.
59.
Ohkubo T, Asayama K, Kikuya M, et al: How many times should blood pressure be measured at home for better prediction of stroke risk? Ten-year follow-up results from the Ohasama study. J Hypertens 2004;22:1099-1104.
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