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1-2 of 2
Keywords: Janus kinase inhibitors
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Journal Articles
Filgotinib to Treat Acute Severe Refractory Ulcerative Colitis: A Case Report and Review of the Literature
Open AccessSubject Area:
Gastroenterology
Giuliana Vespere, Silvia Sedda, Pasquale Madonna, Roberta Abete, Alfredo D'Avino, Manuela Maione, Marina Lugarà, Antonietta Tazza, Franco Scaldaferri, Giuseppe Vitiello, Leonardo De Luca
Journal:
Case Reports in Gastroenterology
Case Rep Gastroenterol (2025) 19 (1): 289–297.
Published Online: 25 April 2025
... clinical and biochemical benefits. The patient declined the surgical option. Therefore, we decided to start a second rescue therapy with a new and rapid-acting Janus kinase inhibitor, filgotinib, due to its characteristics and pharmacokinetic profile of rapid absorption and metabolism. The patient showed...
Journal Articles
Subject Area:
Gastroenterology
David Huynh, Myat Myat Khaing, Richard Gareth Fernandes, Reuben Malloy, Lei Lin, Robert Gilmore, Nicole Walker, Emi Khoo, Jakob Begun
Journal:
Case Reports in Gastroenterology
Case Rep Gastroenterol (2025) 19 (1): 1–6.
Published Online: 23 December 2024
... are the primary treatment, cases that are unresponsive often require rescue therapy with either infliximab or cyclosporine to reduce the rate of colectomy. Janus kinase inhibitors, such as tofacitinib and upadacitinib, are a highly efficacious therapy with rapid induction of clinical response in moderate...
