...Jun Xu; Congcong Miao; Zhenchuan Tian; Jinlu Li; Chunmei Zhang; Dongmei Yang Objective: Matrix metalloproteinases (MMPs) exist in human saliva and dentin and play an important role in the degradation of organic matrix in teeth. Chemically modified tetracycline-3 (CMT-3) is an inhibitor of MMPs. CMT...

.... The inhibitory potential of STMP at 0.5, 1.5, 3.5, and 5% against recombinant matrix metalloproteinases (MMPs) MMPs-2 and -9 was assessed by zymography. To investigate its remineralization potential, 40 bovine root specimens were obtained and subjected to a demineralization protocol to produce caries-like dentin...

...Stella F. do Amaral; Polliana M.C. Scaffa; Renata D.S. Rodrigues; Douglas Nesadal; Marcia M. Marques; Fernando N. Nogueira; Maria Angela Pita Sobral The aim of this study was to evaluate the effect of pH on the activation of matrix metalloproteinases (MMPs) of human coronal (CD) and radicular...

.... Bacterial acidification not only induces demineralization and exposure of the organic matrix in dentin/root surfaces but also activation of dentin-embedded and salivary matrix metalloproteinases and cathepsins. These phenomena initiate degradation of the demineralized organic matrix in dentin/root surfaces...

...Pinar Altinci; Murat Mutluay; Roda Seseogullari-Dirihan; David Pashley; Leo Tjäderhane; Arzu Tezvergil-Mutluay Matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs) degrade the collagen fibrils of demineralized dentin. Sodium fluoride (NaF) has previously been shown to inhibit recombinant...

...P.N. Tannure; E.C. Küchler; P. Falagan-Lotsch; L.M.F. Amorim; R. Raggio Luiz; M.C. Costa; A.R. Vieira; J.M. Granjeiro Recent evidence suggests that genetic studies may contribute to a better understanding of individual susceptibility to caries. Matrix metalloproteinases (MMPs) and their tissue...

...M. Toledano; M. Yamauti; E. Osorio; R. Osorio Background: Dentine matrix metalloproteinases (MMPs) play an important role in the dentine caries process. Aims: To determine if MMP-mediated collagen degradation of acid-demineralized dentine may be inhibited by zinc or zinc chelators. Methods: Human...

... the extracts were not precipitated with ammonium sulfate and dialyzed (table 1 ). Thus, the steps involving precipitation with ammonium sulfate followed by dialysis that were originally described in the protocol of Mazzoni et al. [2007] were not employed in the present study. Matrix metalloproteinases...

...A.J.P. van Strijp; D.C. Jansen; J. DeGroot; J.M. ten Cate; V. Everts Dentine root caries is a process of demineralization and degradation of the organic matrix by proteinases. In this in situ study, the presence and activity of the matrix metalloproteinases 1, 2 and 9 (MMP-1, MMP-2, MMP-9...