The effect of fluoride administration on skeletal fluoride retention was studied in the unilaterally nephrectomized rat. In series I, fluoride (as NaF) was administered by stomach tube for 30 days in daily doses of 0 (control), 0.5, 1.0 and 2.0 mg F––. In series II, fluoride was administered in drinking water ad libitum for 106 days at concentrations of 0 (controls), 25 and 100 ppm F––. Each dosage group of rats consisted of: (1) unoperated animals, (2) sham-operated rats and (3) unilaterally nephrectomized rats. There were 8 rats in each subgroup. The fluoride retention in the femora and in the whole carcasses of series I animals was found to be without significant differences between the subgroups of unoperated, sham-operated and nephrectomized rats within the respective fluoride dosage levels. The fluoride administration in drinking-water at the 25- and 100-ppm F–– levels over a longer period of 106 days, however, resulted in significant increases of skeletal fluoride retention in unilaterally nephrectomized rats as compared to sham-operated rats.

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