For an Organisation for Caries Research/European Federation of Conservative Dentistry consensus, this systematic review is aimed to assess the question of how to manage the caries process in the case of early childhood caries (ECC). Medline via PubMed was searched systematically regarding management of ECC. First priority was existing systematic reviews or randomized clinical trials otherwise cohort studies dealing with management of ECC, primarily with carious anterior teeth. After data extraction, the potential risk of bias was estimated depending on the study types, and the level of evidence was evaluated. Regarding management of ECC, results are presented for silver diamine fluoride (SDF, n = 5), nonoperative caries management (NOCM, n = 10), and restorative approaches (RA, n = 8) separately, as different kinds of studies with different levels of evidence were found for the different aspects in the management of ECC. The 5 systematic reviews on SDF showed a high potential for arrest of ECC on a high level of evidence. In NOCM, a low level of evidence for a moderate effect of fluoride varnish in arresting or remineralizing, especially non-cavitated lesions, was assessed. For RA in carious anterior upper primary teeth, a low level of evidence was found for higher failure rates of glass ionomer cement and composite fillings than composite strip crowns even if placed under general anaesthesia and especially compared to other crowns (stainless steel and zirconia). In conclusions, ECC may be managed successfully with nonoperative (SDF, regular fluoride application) and moderately well with operative approaches, but the decision is affected by many other variables such as pulpal involvement, the child’s cooperation, or a general anaesthesia setting.

1.
Amin
M
,
Nouri
MR
,
Hulland
S
,
ElSalhy
M
,
Azarpazhooh
A
.
Success rate of treatments provided for Early Childhood Caries under general anesthesia: A retrospective cohort study
.
Pediatr Dent
.
2016
;
38
(
4
):
317
24
.
[PubMed]
1942-5473
2.
Arrow
P
.
Restorative outcomes of a minimally invasive restorative approach based on atraumatic restorative treatment to manage Early Childhood Caries: A randomised controlled trial
.
Caries Res
.
2016
;
50
(
1
):
1
8
.
[PubMed]
0008-6568
3.
Autio-Gold
JT
,
Courts
F
.
Assessing the effect of fluoride varnish on early enamel carious lesions in the primary dentition
.
J Am Dent Assoc
.
2001
Sep
;
132
(
9
):
1247
53
.
[PubMed]
0002-8177
4.
Bücher
K
,
Tautz
A
,
Hickel
R
,
Kühnisch
J
.
Longevity of composite restorations in patients with early childhood caries (ECC)
.
Clin Oral Investig
.
2014
Apr
;
18
(
3
):
775
82
.
[PubMed]
1432-6981
5.
Casamassimo
PS
,
Thikkurissy
S
,
Edelstein
BL
,
Maiorini
E
.
Beyond the dmft: the human and economic cost of early childhood caries
.
J Am Dent Assoc
.
2009
Jun
;
140
(
6
):
650
7
.
[PubMed]
0002-8177
6.
Chen
KJ
,
Gao
SS
,
Duangthip
D
,
Lo
EC
,
Chu
CH
.
Early childhood caries and oral health care of Hong Kong preschool children
.
Clin Cosmet Investig Dent
.
2019
Jan
;
11
:
27
35
.
[PubMed]
1179-1357
7.
Chibinski
AC
,
Wambier
LM
,
Feltrin
J
,
Loguercio
AD
,
Wambier
DS
,
Reis
A
.
Silver diamine fluoride has efficacy in controlling caries progression in primary teeth: A systematic review and meta-analysis
.
Caries Res
.
2017
;
51
(
5
):
527
41
.
[PubMed]
0008-6568
8.
Chu
CH
,
Lo
EC
,
Lin
HC
.
Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children
.
J Dent Res
.
2002
Nov
;
81
(
11
):
767
70
.
[PubMed]
0022-0345
9.
Collado
V
,
Pichot
H
,
Delfosse
C
,
Eschevins
C
,
Nicolas
E
,
Hennequin
M
.
Impact of early childhood caries and its treatment under general anesthesia on orofacial function and quality of life : A prospective comparative study
.
Med Oral Patol Oral Cir Bucal
.
2017
May
;
22
(
3
):
e333
41
.
[PubMed]
1698-4447
10.
Contreras
V
,
Toro
MJ
,
Elías-Boneta
AR
,
Encarnación-Burgos
A
.
Effectiveness of silver diamine fluoride in caries prevention and arrest: a systematic literature review
.
Gen Dent
.
2017
May-Jun
;
65
(
3
):
22
9
.
[PubMed]
0363-6771
11.
Divaris
K
,
Preisser
JS
,
Slade
GD
.
Surface-specific efficacy of fluoride varnish in caries prevention in the primary dentition: results of a community randomized clinical trial
.
Caries Res
.
2013
;
47
(
1
):
78
87
.
[PubMed]
0008-6568
12.
Drury
TF
,
Horowitz
AM
,
Ismail
AI
,
Maertens
MP
,
Rozier
RG
,
Selwitz
RH
.
Diagnosing and reporting early childhood caries for research purposes. A report of a workshop sponsored by the National Institute of Dental and Craniofacial Research, the Health Resources and Services Administration, and the Health Care Financing Administration
.
J Public Health Dent
.
1999
;
59
(
3
):
192
7
.
[PubMed]
0022-4006
13.
Duangthip
D
,
Jiang
M
,
Chu
CH
,
Lo
EC
.
Non-surgical treatment of dentin caries in preschool children—systematic review
.
BMC Oral Health
.
2015
Apr
;
15
(
1
):
44
.
[PubMed]
1472-6831
14.
Duangthip
D
,
Wong
MC
,
Chu
CH
,
Lo
EC
.
Caries arrest by topical fluorides in preschool children: 30-month results
.
J Dent
.
2018
Mar
;
70
:
74
9
.
[PubMed]
0300-5712
15.
Eshghi
A
,
Kowsari-Isfahan
R
,
Khoroushi
M
.
Evaluation of three restorative techniques for primary anterior teeth with extensive carious lesions: a 1-year clinical study
.
J Dent Child (Chic)
.
2013
May-Aug
;
80
(
2
):
80
7
.
[PubMed]
1935-5068
16.
Gao
SS
,
Zhang
S
,
Mei
ML
,
Lo
EC
,
Chu
CH
.
Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review
.
BMC Oral Health
.
2016
Feb
;
16
(
1
):
12
.
[PubMed]
1472-6831
17.
Gao
SS
,
Zhao
IS
,
Hiraishi
N
,
Duangthip
D
,
Mei
ML
,
Lo
EC
, et al.
Clinical trials of silver diamine fluoride in arresting caries among children: A systematic review
.
JDR Clin Trans Res
.
2016
Oct
;
1
(
3
):
201
10
.
[PubMed]
2380-0844
18.
Itaborahy
R
,
Machado
FC
,
Elias
GP
,
Ribeiro
LC
,
Ribeiro
RA
.
Clinical effectiveness of two commercial fluoride varnish formulations on the control of white spot lesion in primary teeth: A pilot study
.
Pesqui Bras Odontopediatria Clin Integr
.
2015
;
15
:
41
8
. 1519-0501
19.
Liberati
A
,
Altman
DG
,
Tetzlaff
J
,
Mulrow
C
,
Gøtzsche
PC
,
Ioannidis
JP
,
Clarke
M
,
Devereaux
PJ
,
Kleijnen
J
,
Moher
D
: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med
2009
; 21:6(7)
20.
Lo
EC
,
Schwarz
E
,
Wong
MC
.
Arresting dentine caries in Chinese preschool children
.
Int J Paediatr Dent
.
1998
Dec
;
8
(
4
):
253
60
.
[PubMed]
0960-7439
21.
Machiulskiene
V
,
Campus
G
,
Carvalho
JC
,
Dige
I
,
Ekstrand
KR
,
Jablonski-Momeni
A
, et al.
Terminology of dental caries and dental Caries management: consensus report of a workshop organized by ORCA and Cariology Research Group of IADR
.
Caries Res
.
2019
Oct
;
1
8
.
[PubMed]
0008-6568
22.
Memarpour
M
,
Fakhraei
E
,
Dadaein
S
,
Vossoughi
M
.
Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial
.
Med Princ Pract
.
2015
;
24
(
3
):
231
7
.
[PubMed]
1011-7571
23.
Oliveira
BH
,
Rajendra
A
,
Veitz-Keenan
A
,
Niederman
R
.
The effect of silver diamine fluoride in preventing caries in the primary dentition: A systematic review and meta-analysis
.
Caries Res
.
2019
;
53
(
1
):
24
32
.
[PubMed]
0008-6568
24.
Peretz
B
,
Gluck
G
.
Early childhood caries (ECC): a preventive-conservative treatment mode during a 12-month period
.
J Clin Pediatr Dent
.
2006
;
30
(
3
):
191
4
.
[PubMed]
1053-4628
25.
Ram
D
,
Fuks
AB
.
Clinical performance of resin-bonded composite strip crowns in primary incisors: a retrospective study
.
Int J Paediatr Dent
.
2006
Jan
;
16
(
1
):
49
54
.
[PubMed]
0960-7439
26.
Sawant
A
,
Chunawalla
Y
,
Morawala
A
,
S Kanchan
N
,
Jain
K
,
Talathi
R
.
Evaluation of novel glass fiber-reinforced composite technique for primary anterior teeth with deep carious lesions: A 12-month clinical study
.
Int J Clin Pediatr Dent
.
2017
Apr-Jun
;
10
(
2
):
126
30
.
[PubMed]
0974-7052
27.
Sitthisettapong
T
,
Phantumvanit
P
,
Huebner
C
,
Derouen
T
.
Effect of CPP-ACP paste on dental caries in primary teeth: a randomized trial
.
J Dent Res
.
2012
Sep
;
91
(
9
):
847
52
.
[PubMed]
0022-0345
28.
Slayton
RL
,
Urquhart
O
,
Araujo
MW
,
Fontana
M
,
Guzmán-Armstrong
S
,
Nascimento
MM
, et al.
Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association
.
J Am Dent Assoc
.
2018
Oct
;
149
(
10
):
837
849.e19
.
[PubMed]
0002-8177
29.
Thomson
WM
.
Public Health aspects of paediatric dental treatment under general anaesthetic.
Dent J (Basel)
2016
; 8:4(2).
30.
Tinanoff
N
,
Baez
RJ
,
Diaz Guillory
C
,
Donly
KJ
,
Feldens
CA
,
McGrath
C
, et al.
Early childhood caries epidemiology, aetiology, risk assessment, societal burden, management, education, and policy: global perspective
.
Int J Paediatr Dent
.
2019
May
;
29
(
3
):
238
48
.
[PubMed]
0960-7439
31.
Trairatvorakul
C
,
Piwat
S
.
Comparative clinical evaluation of slot versus dovetail Class III composite restorations in primary anterior teeth
.
J Clin Pediatr Dent
.
2004
;
28
(
2
):
125
9
.
[PubMed]
1053-4628
32.
Waggoner
WF
.
Restoring primary anterior teeth: updated for 2014
.
Pediatr Dent
.
2015
Mar-Apr
;
37
(
2
):
163
70
.
[PubMed]
1942-5473
33.
Walia
T
,
Salami
AA
,
Bashiri
R
,
Hamoodi
OM
,
Rashid
F
.
A randomised controlled trial of three aesthetic full-coronal restorations in primary maxillary teeth
.
Eur J Paediatr Dent
.
2014
Jun
;
15
(
2
):
113
8
.
[PubMed]
1591-996X
34.
Wyne
AH
.
Early childhood caries: nomenclature and case definition
.
Community Dent Oral Epidemiol
.
1999
Oct
;
27
(
5
):
313
5
.
[PubMed]
0301-5661
35.
Zhi
QH
,
Lo
EC
,
Lin
HC
.
Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children
.
J Dent
.
2012
Nov
;
40
(
11
):
962
7
.
[PubMed]
0300-5712
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