We conducted a 3-year cost-effectiveness analysis on the cavitated dentine carious lesion preventive capabilities of composite resin (CR) (reference group) and atraumatic restorative treatment (ART) high-viscosity glass-ionomer cement (HVGIC) sealants compared to supervised toothbrushing (STB) in high-risk first permanent molars. School children aged 6-7 years in 6 schools (2 per group) received CR and ART/HVGIC sealants or STB daily for 180 days each school year. Data were collected prospectively and cost estimates were made for sample data and a projection of 1,000 sealants/STB high-risk permanent molars. Although STB had the best outcome, its high implementation cost (95% of cost for supervisors visiting schools 180 days/school year) affected the results. ART/HVGIC was cost-effective compared to CR for the sample data (savings of USD 37 per cavitated dentine carious lesion prevented), while CR was cost-effective compared to ART/HVGIC for the projection (savings of USD 17 per cavitated dentine carious lesion prevented), and both were cost-saving compared to STB. Two STB scenarios were tested in sensitivity analyses with variations in caries incidence and number of supervision days; results showed STB had lower costs and higher savings per cavitated dentine carious lesion prevented than CR and ART/HVGIC. A major assumption is that both scenarios have the same high effectiveness rate experienced by STB under study conditions; however, they point to the value of further research on the benefits of adopting STB as a long-term venture in a general population of school children.

1.
Ahovuo-Saloranta A, Forss H, Walsh T, Hiiri A, Nordblad A, Mäkelä M, Worthington HV: Sealants for preventing dental decay in the permanent teeth. Cochrane Database Syst Rev 2013;28:CD001830, 3.
2.
Ampt A, Westbrook J, Creswick N, Mallock N: A comparison of self-reported and observational work sampling techniques for measuring time in nursing tasks. J Health Serv Res Policy 2007;12:18-24.
3.
Anopa Y, McMahon AD, Conway DI, Ball GE, McIntosh E, Mcpherson LM: Improving child oral health: cost analysis of a national nursery toothbrushing programme. PLoS One 2015; 10(8):e0136211.
4.
Beiruti N, Frencken JE, van't Hof MA, Taifour D, van Palenstein Helderman WH: Caries-preventive effect of a one-time application of composite resin and glass ionomer sealants after 5 years. Caries Res 2006a;40:52-59.
5.
Beiruti N, Frencken JE, van ‘t Hof MA, van Palenstein Helderman WH: Caries-preventive effect of resin-based and glass ionomer sealants over time: a systematic review. Community Dent Oral Epidemiol 2006b;34:403-409.
6.
Carvalho JC, Thylstrup A, Ekstrand KR: Results after 3 years of non-operative occlusal caries treatment of erupting permanent first molars. Community Dent Oral Epidemiol 1992;20:187-192.
7.
Castilho AR, Mialhe FL, Barbosa TS, Puppin-Rontani RM: Influence of family environment on children's oral health: a systematic review. J Pediatr (Rio J) 2013;89:116-123.
8.
Curnow MM, Pine CM, Burnside G, Nicholson JA, Chesters RK, Huntington E: A randomised controlled trial of the efficacy of supervised toothbrushing in high-caries-risk children. Caries Res 2002;36:294-300.
9.
Cury JA, Tenuta LM, Ribeiro CC, Paes Leme AF: The importance of fluoride dentifrices to the current dental caries prevalence in Brazil. Braz Dent J 2004;15:167-174.
10.
da Silva SN, Gimenez T, Souza RC, Mello-Moura AC, Raggio DP, Morimoto S, Lara JS, Soares GC, Tedesco TK: Oral health status of children and young adults with autism disorders: systematic review and meta-analysis. Int J Paediatr Dent 2016, DOI:10.1111/ipd.12274.
11.
de Amorim RG, Figueiredo MJ, Leal SC, Mulder J, Frencken JE: Caries experience in a child population in a deprived area of Brazil, using ICDAS II. Clin Oral Investig 2012;16:513-520.
12.
de Amorim RG, Leal SC, Mulder J, Creugers NH, Frencken JE: Amalgam and ART restorations in children: a controlled clinical trial. Clin Oral Investig 2014;18:117-124.
13.
Ekstrand KR, Christiansen ME: Outcomes of a non-operative caries treatment programme for children and adolescents. Caries Res 2005;39:455-467.
14.
Frazão P: Effectiveness of the bucco-lingual technique within a school-based supervised toothbrushing program on preventing caries: a randomized controlled trial. BMC Oral Health 2011;11:11.
15.
Frencken JE, Peters MC, Manton DJ, Leal SC, Gordan VV, Eden E: Minimal intervention dentistry for managing dental caries - a review: report of a FDI task group. Int Dent J 2012;62:223-243.
16.
Frencken JE, Pilot T, Songpaisan Y, Phantumvanit P: Atraumatic restorative treatment (ART): rationale, technique, and development. J Public Health Dent 1996;56:135-140.
17.
Gold MR, Siegel JE, Russel LB, Weinstein MC (eds): Cost-effectiveness in health and medicine. New York, Oxford University Press, 1996, p 425.
18.
Goldman AS, Chen X, Fan M, Frencken JE: Methods and preliminary findings for a cost-effectiveness study of glass-ionomer-based and composite resin sealant materials after 2 years. Eur J Oral Sci 2014;122:230-237.
19.
Goldman AS, Chen X, Fan M, Frencken JE: Cost-effectiveness, in a randomized trial, of glass-ionomer-based and resin sealant materials after 4 yr. Eur J Oral Sci 2016;124:472-479.
20.
Granham H: Social determinants and their unequal distribution: clarifying policy understandings. Milbank Q 2004;82:101-124.
21.
Haddix AC, Tatsch SM, Corso PS (eds): Prevention Effectiveness: A Guide to Decision Analysis and Economic Evaluation. New York, Oxford University Press, 2003, p 288.
22.
Heller KE, Reed SG, Bruner FW, Eland SA, Burt BA: Longitudinal evaluation of sealing molars with and without incipient dental caries in a public health program. J Public Health Dent 1995;55:148-153.
23.
Hiiri A, Ahovuo-Saloranta A, Nordblad A, Mäkelä M: Pit and fissure sealants versus fluoride varnishes for preventing dental decay in children and adolescents. Cochrane Database Syst Rev 2010;17:CD003067.
24.
Hilgert LA, Leal SC, Bronkhorst EM, Frencken JE: Long-term effect of supervised toothbrushing on levels of plaque and gingival bleeding among schoolchildren. Oral Health Prev Dent 2017, in press.
25.
Hilgert LA, Leal SC, Mulder J, Creugers NHJ, Frencken JE: Caries-preventive effect of supervised toothbrushing, composite resin and ART sealants: a cluster-randomized controlled clinical trial. J Dent Res 2015;94:1218-1224.
26.
Kallestal C, Norlund A, Soder B, Nordenram G, Dahlgren H, Petersson LG, Lagerlof F, Axelsson S, Lingstrom P, Mejare I, Holm AK, Twetman S: Economic evaluation of dental caries prevention: a systematic review. Acta Odontol Scand 2003;61:41-346.
27.
Kidd E: Should deciduous teeth be restored? Reflections of a cariologist. Dent Update 2012;39:159-162,165-166.
28.
Kühnisch J, Mansmann U, Heinrich-Weltzien R, Hickel R: Longevity of materials for pit and fissure sealing - results from a meta-analysis. Dent Mater 2012;28:298-303.
29.
Liu BY, Xiao Y, Chu CH, Lo EC: Glass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries prevention - results from a randomized clinical trial. BMC Oral Health 2014;14:54.
30.
Lo EC, Schawrz E, Wong MC: Arresting dentine caries in Chinese preschool children. Int J Paediatr Dent 1998;8:253-260.
31.
Mariño RJ, Khan AR, Morgan M: Systematic review of publications on economic evaluations of caries prevention programs. Caries Res 2013;47:265-272.
32.
Mickenautsch S, Yengopal V: Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: an update of systematic review evidence. BMC Res Notes 2011;4:22.
33.
Ministério da Saúde (Brasil), Secretaría de Atenção a Saúde, Departamento de Atenção Básica: Política Nacional de Atenção Básica. Brazil, Ministério da Saúde, Secretaría de Atenção a Saúde, Departamento de Atenção Básica, 2012.
34.
Moysés SJ: Inequalities in oral health and oral health promotion. Braz Oral Res 2012;26(suppl 1):86-93.
35.
Moysés ST, Moysés SJ, Watt RG, Sheiham A: Associations between health promoting schools policies and indicators of oral health in Brazil. Health Prom Int 2003;18:209-218.
36.
Neusser S, Krauth C, Hussein R, Bitzer EM: Clinical effectiveness and cost-effectiveness of fissure sealants in children and adolescents with a high caries risk. GMS Health Technol Assess 2014;10:Doc02.
37.
Pucca Jr GA, Gabriel M, de Araújo ME, de Almeida FCS: Ten years of a national oral health policy in Brazil: innovation, boldness, and numerous challenges. J Dent res 2015;94:1333-1337.
38.
Symons AL, Chu CY, Meyers IA: The effect of fissure morphology and pretreatment of the enamel surface on penetration and adhesion of fissure sealants. J Oral Rehabil 1996;23:791-798.
39.
The World Bank Group: World Development Indicators. 2016. http://databank.worldbank.org/Data/Home.aspx.
40.
Vermaire JH, Poorterman JH, van Herwijnen L, van Loveren C: A three-year randomized controlled trial in 6-year-old children on caries-preventive strategies in a general dental practice in the Netherlands. Caries Res 2014;48:524-533.
41.
Victora CG, Vaughan JP, Barros FC, Silva AC, Tomasi E: Explaining trends in inequities: evidence from Brazilian child health studies. Lancet 2000;156:1093-1098.
42.
World Health Organization (WHO): Making Choices in Health; Tan-Torres Edejer T, Baltussen R, Adam T, Hutubessy R, Acharya A, Evans DB, Murray CJ (eds): WHO Guide to Cost-Effectiveness Analysis. Geneva, WHO, 2003, p 318.
43.
Wright JT, Tampi MP, Graham L, Estrich C, Crall JJ, Fontana M, Gillete EJ, Novy BB, Dhar V, Donly K, Hewlett ER, Quinonez RB, Chaffin J, Crespin M, Iafolla T, Siegal MD, Carrasco-Labra A: Sealants for preventing and arresting pit-and-fissure occlusal caries in primary and permanent molars: a systematic review of randomized controlled trials - a report of the American Dental Association and the American Academy of Pediatric Dentistry. JADA 2016;147:631-645.
44.
Zhang W, Chen X, Fan M-W, Mulder J, Huysmans MC, Frencken JE: Do light cured ART conventional high-viscosity glass-ionomer sealants perform better than resin-composite sealants: a 4-year randomized clinical trial. Dent Mater 2014;30:487-492.
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