Aim: The aim of this study was to compare the caries experience of children with and without molar-incisor hypomineralisation (MIH). Methods: A case-control study was designed in which 130 children aged between 7 and 13 years with MIH (cases) were matched with 130 children without the condition (controls) according to age, sex, and school. Dental caries and MIH were assessed using the Caries Assessment Spectrum and Treatment (CAST) and European Academy of Paediatric Dentistry (EAPD) criteria, respectively, by three examiners. CAST was converted into DMFT/dmft; the Kruskal-Wallis test was performed to analyse whether dmft/DMFT was influenced by the severity of MIH. Associations between MIH and dental caries were analysed at child and tooth levels: between and within subjects, respectively. To correlate MIH severity and the occurrence of dental caries, the Cochran-Armitage test was used. Results: The mean age of the children was 9.63 ± 1.29 years. The mean dmft for cases was 1.23 ± 1.99 and for controls 1.71 ± 2.22 (p > 0.05). For the DMFT, the mean scores for cases and controls were 0.45 ± 0.90 and 0.07 ± 0.25, respectively (p < 0.001). The between-subject analysis showed no difference in relation to enamel carious lesions; however, the prevalence of dentine carious lesions was significantly higher in children with MIH than in those without the condition. The same pattern was seen for the within-subject analysis. It was observed that the increase in MIH severity resulted in more teeth being affected by dentine carious lesions (p = 0.0003). Conclusion: Children with MIH presented a higher experience of caries in the permanent dentition than those without the condition. MIH was considered a risk factor for caries development.

1.
Americano GCA, Jacobsen PE, Soviero VM, Haubek D: A systematic review on the association between molar incisor hypomineralization and dental caries. Int J Paediatr Dent 2017;27:11-21.
2.
Atlas de Desenvolvimento Humano no Brasil (Brazilian Human Development Atlas). 2013. http://www.atlasbrasil.org.br/2013/pt/perfil_udh/22939 (accessed September 20, 2016).
3.
Crombie FA, Manton DJ, Palamara JE, Zalizniak I, Cochrane NJ, Reynolds EC: Characterisation of developmentally hypomineralised human enamel. J Dent 2013;41:611-618.
4.
Da Costa-Silva CM, Jeremias F, de Souza JF, Cordeiro R de CL, Santos-Pinto L, Zuanon ACC: Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent 2010;20:426-434.
5.
De Oliveira DC, Favretto CO, Cunha, RF: Molar incisor hypomineralization: considerations about treatment in a controlled longitudinal case. J Indian Soc Pedod Prev Dent 2015;33:152-155.
6.
De Souza AL, Leal SC, Bronkhorst EM, Frencken JE: Assessing caries status according to the CAST instrument and WHO criterion in epidemiological studies. BMC Oral Health 2014;14:119.
7.
De Souza AL, van der Sanden WJM, Leal SC, Frencken JE: The Caries Assessment Spectrum and Treatment (CAST) index: face and content validation. Int Dent J 2012;62:270-276.
8.
Farah RA, Swain MV, Drummond BK, Cook R, Atieh M: Mineral density of hypomineralised enamel. J Dent 2010;38:50-58.
9.
Garcia-Margarit M, Catalá-Pizarro M, Montiel-Company JM, Almerich-Silla JM: Epidemiologic study of molar-incisor hypomineralization in 8-year-old Spanish children. Int J Paediatr Dent 2014;24:14-22.
10.
Ghanim AM, Manton DJ, Morgan MV, Mariño RJ, Bailey DL: Trends of oral health care and dental treatment needs in relation to molar incisor hypomineralisation defects: a study amongst a group of Iraqi schoolchildren. Eur Arch Paediatr Dent 2012;13:171-178.
11.
Heitmüller D, Thiering E, Hoffmann U, Heinrich J, Manton D, Kühnisch J, et al: Is there a positive relationship between molar incisor hypomineralisations and the presence of dental caries? Int J Paediatr Dent 2013;23:116-124.
12.
Jälevik B, Klingberg G: Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent 2002;12:24-32.
13.
Jälevik B, Klingberg G: Treatment outcomes and dental anxiety in 18-year-olds with MIH, comparisons with healthy controls - a longitudinal study. Int J Paediatr Dent 2012;22:85-91.
14.
Jeremias F, de Souza JF, Silva CMDC, Cordeiro R de CL, Zuanon ACC, Santos-Pinto L: Dental caries experience and molar-incisor hypomineralization. Acta Odontol Scand 2013;71:870-876.
15.
Kosma I, Kevrekidou A, Boka V, Arapostathis K, Kotsanos N: Molar incisor hypomineralisation (MIH): correlation with dental caries and dental fear. Eur Arch Paediatr Dent 2016;17:123-129.
16.
Leppäniemi A, Lukinmaa PL, Alaluusua S: Nonfluoride hypomineralizations in the permanent first molars and their impact on the treatment need. Caries Res 2001;35:36-40.
17.
Lygidakis NA: Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent 2010;11:65-74.
18.
Lygidakis NA, Dimou G, Briseniou E: Molar-incisor-hypomineralisation (MIH). Retrospective clinical study in Greek children. I. Prevalence and defect characteristics. Eur Arch Paediatr Dent 2008;9:200-206.
19.
Mancl LA, Leroux BG, DeRouen TA: Between-subject and within-subject statistical information in dental research. J Dent Res 2000;79:1778-1781.
20.
Oliver K, Messer LB, Manton DJ, Kan K, Ng F, Olsen C, Sheahan J, Silva M, Chawla N: Distribution and severity of molar hypomineralisation: trial of a new severity index. Int J Paediatr Dent 2014;24:131-151.
21.
Petrou MA, Giraki M, Bissar A-R, Basner R, Wempe C, Altarabulsi MB, et al: Prevalence of molar-incisor-hypomineralisation among school children in four German cities. Int J Paediatr Dent 2013;24:434-440.
22.
Pitiphat W, Savisit R, Chansamak N, Subarnbhesaj A: Molar incisor hypomineralization and dental caries in six- to seven-year-old Thai children. Pediatr Dent 2014;36:478-482.
23.
Santos MPA, Maia LC: Molar incisor hypomineralization: morphological, aetiological, epidemiological and clinical considerations; in Li MY (ed): Contemporary Approach to Dental Caries. Shanghai, InTech, 2012. www.intechopen.com/books/contemporary-approach-to-dental-caries/molar-incisor-hypomineralization-epidemiological-morphological-and-clinical-considerations.
24.
Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N: Etiology of molar incisor hypomineralization - a systematic review. Community Dent Oral Epidemiol 2016;44:342-353.
25.
Weerheijm KL: Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent 2003;4:114-120.
26.
Weerheijm KL, Duggal M, Mejàre I, Papagiannoulis L, Koch G, Martens LC, et al: Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent 2003;4:110-113.
27.
Weerheijm KL, Jälevik B, Alaluusua S: Molar-incisor hypomineralisation. Caries Res 2001;35:390-391.
28.
Willmott NS, Bryan RAE, Duggal MS: Molar-incisor-hypomineralisation: a literature review. Eur Arch Paediatr Dent 2008;9:172-179.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.