Urinary fluoride excretion under different conditions was examined using a fluoride ion activity electrode. The mean 24-hour urinary fluoride excretion in adult women was 0.89 mg in Basel with water-fluoridation at the 1 ppm level. In two women using a domestic salt with 250 mg F/kg the mean fluoride excretion was 1.04 mg and in three persons working in a children’s home using the same salt it was 1.19 mg. This result seems to indicate, that a packeted salt with 250 mg F/kg should produce about the same caries-protective effect as water-fluoridation. With salt-fluoridation the urinary fluoride concentration reaches its maximum 2–4 hours after a meal. In the urine of newborn boys the mean fluoride concentration was 0.08 ppm compared with 0.58 ppm in the post partum urine of their mothers, confirming the placental F-barrier.

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