The aim of the study was to examine the frequencies of the genotypes and alleles of ACE insertion/deletion (I/D) polymorphism and their association with dental caries in a sample of Polish children. The study subjects were 120 children with dental caries experience (cases) and 41 caries-free individuals (controls). The genotyping was performed using polymerase chain reaction. The genotype distributions of ACE I/D polymorphism were not statistically different between carious and control children. However, we found a borderline overrepresentation of the II + ID genotypes versus the DD genotype in the carious compared to the control group (69.2% and 51.2%, respectively, p = 0.057). Logistic regression analysis adjusted for age and sex revealed that I allele carriage was a significant predictor of dental caries susceptibility (OR = 2.14, 95% CI = 1.02-4.49, p = 0.041). In conclusion, the DD genotype of ACE I/D polymorphism might be protective against dental caries in Polish children.

Keywords:
Angiotensin-converting enzyme, Children, Dental caries experience, Genetic polymorphism
1.
Benzian H, Hobdell M, Mackay J: Putting teeth into chronic diseases. Lancet 2011;377:464.
2.
Castellon R, Hamdi HK: Demystifying the ACE polymorphism: from genetics to biology. Curr Pharm Des 2007;13:1191-1198.
3.
Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S, Bernstein KE: Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme. J Mol Med 2013;91:1143-1154.
4.
Gürkan A, Emingil G, Saygan BH, Atilla G, Köse T, Baylas H, Berdeli A: Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis. Arch Oral Biol 2009a;54:337-344.
5.
Gürkan A, Emingil G, Saygan BH, Atilla G, Köse T, Baylas H, Berdeli A: Renin-angiotensin gene polymorphisms in relation to severe chronic periodontitis. J Clin Periodontol 2009b;36:204-211.
6.
Karakus N, Yigit S, Kalkan G, Sezer S: High association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with recurrent aphthous stomatitis. Arch Dermatol Res 2013;305:513-517.
7.
Molęda P, Majkowska L, Kaliszczak R, Safranow K, Adler G, Gorący I: Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus. Kardiol Pol 2006;64:959-965.
8.
Olszowski T, Adler G, Janiszewska-Olszowska J, Safranow K, Kaczmarczyk M: MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children. Oral Dis 2012;18:389-395.
9.
Vairaktaris E, Yapijakis C, Tsigris C, Vassiliou S, Derka S, Nkenke E, Spyridonidou S, Vylliotis A, Vorris E, Ragos V, Neukam FW, Patsouris E: Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer. Acta Oncol 2007;46:1097-1102.
10.
Vieira AR, Modesto A, Marazita ML: Caries: review of human genetics research. Caries Res 2014;48:491-506.
11.
Wang Q, Jia P, Cuenco KT, Feingold E, Marazita ML, Wang L, Zhao Z: Multi-dimensional prioritization of dental caries candidate genes and its enriched dense network modules. PLoS One 2013;8:e76666.
12.
Wang X, Shaffer JR, Weyant RJ, Cuenco KT, DeSensi RS, Crout R, McNeil DW, Marazita ML: Genes and their effects on dental caries may differ between primary and permanent dentitions. Caries Res 2010;44:277-284.
13.
Werneck RI, Mira MT, Trevilatto PC: A critical review: an overview of genetic influence on dental caries. Oral Dis 2010;16:613-623.
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2015
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