The aim of this prospective cohort study was to evaluate the risk of posteruptive breakdown and the development of caries lesions in teeth with molar incisor hypomineralisation (MIH). A total of 367 permanent incisors and first molars, affected and not affected by MIH lesions, of 45 children with MIH from Araraquara, São Paulo, Brazil, were evaluated at intervals from 6 to 12 months by assessing the severity of MIH, the presence of tooth caries lesions and the treatment needed. During the study period, all patients received preventive care. The data were analysed using Fisher's exact test and actuarial method survival analysis. Significant associations were also found in teeth between the presence of MIH and a DMFT index >0 in all periods and also between the need for treatment and the presence of MIH. The teeth affected by MIH opacities were healthy in 99% of incisors and 93% of molars at the end of the 12-month period. Due to the high likelihood of maintaining the tooth structure in opacities, the complete or premature removal of the affected area is not justified.

1.
Alaluusua S: Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent 2010;11:53-58.
2.
Crombie F, Manton D, Kilpatrick N: Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent 2009;19:73-83.
3.
Da Costa-Silva CM, Ambrosano GM, Jeremias F, De Souza JF, Mialhe FL: Increase in severity of molar-incisor hypomineralization and its relationship with the colour of enamel opacity: a prospective cohort study. Int J Paediatr Dent 2011;21:333-341.
4.
Da Costa-Silva CM, Jeremias F, de Souza JF, Cordeiro Rde C, Santos-Pinto L, Zuanon AC: Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent 2010;20:426-434.
5.
Jalevik B: Prevalence and diagnosis of molar-incisor hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent 2010;11:59-64.
6.
Jalevik B, Klingberg GA: Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent 2002;12:24-32.
7.
Jalevik B, Klingberg GA, Barregard L, Noren JG: The prevalence of demarcated opacities in permanent first molars in a group of Swedish children. Acta Odontol Scand 2001;59:255-260.
8.
Jalevik B, Noren JG: Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent 2000;10:278-289.
9.
Jeremias F, De Souza JF, Da Costa-Silva CM, Cordeiro RC, Zuanon AC, Santos-Pinto L. Dental caries experience and molar-incisor hypomineralization. Acta Odontol Scand 2013;71:870-876.
10.
Leppaniemi A, Lukinmaa PL, Alaluusua S: Nonfluoride hypomineralizations in the permanent first molars and their impact on the treatment need. Caries Res 2001;35:36-40.
11.
Lygidakis NA, Chaliasou A, Siounas G: Evaluation of composite restorations in hypomineralised permanent molars: a four year clinical study. Eur J Paediatr Dent 2003;4:143-148.
12.
Lygidakis NA, Wong F, Jalevik B, Vierrou AM, Alaluusua S, Espelid I: Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor hypomineralisation (MIH): an EAPD policy document. Eur Arch Paediatr Dent 2010;11:75-81.
13.
Mahoney E, Ismail FS, Kilpatrick N, Swain M: Mechanical properties across hypomineralized/hypoplastic enamel of first permanent molar teeth. Eur J Oral Sci 2004a;112:497-502.
14.
Mahoney EK, Rohanizadeh R, Ismail FS, Kilpatrick NM, Swain MV: Mechanical properties and microstructure of hypomineralised enamel of permanent teeth. Biomaterials 2004b;25:5091-5100.
15.
Mejare I, Bergman E, Grindefjord M: Hypomineralized molars and incisors of unknown origin: treatment outcome at age 18 years. Int J Paediatr Dent 2005;15:20-28.
16.
Muratbegovic A, Markovic N, Ganibegovic Selimovic M: Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population. Eur Arch Paediatr Dent 2007;8:189-194.
17.
World Health Organisation: Oral Health Surveys: Basic Methods. Geneva, World Health Organisation, 1997.
18.
Szklo M, Nieto F: Epidemiology: Beyond the Basics. Burlington, Jones & Bartlett Learning, 2000.
19.
Takahashi K, Correia Ade S, Cunha RF: Molar incisor hypomineralization. J Clin Pediatr Dent 2009;33:193-197.
20.
Weerheijm KL: Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent 2003;4:114-120.
21.
Weerheijm KL: Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update 2004;31:9-12.
22.
Weerheijm KL, Duggal M, Mejare I, Papagiannoulis L, Koch G, Martens LC, Hallonsten AL: Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent 2003;4:110-113.
23.
Xie Z, Kilpatrick NM, Swain MV, Munroe PR, Hoffman M: Transmission electron microscope characterisation of molar-incisor hypomineralisation. J Mater Sci Mater Med 2008;19:3187-3192.
24.
Zagdwon AM, Fayle SA, Pollard MA: A prospective clinical trial comparing preformed metal crowns and cast restorations for defective first permanent molars. Eur J Paediatr Dent 2003;4:138-142.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.