Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S–L–, S+L–, S–L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S–L– groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

Keywords:
Biofilms, In situ study, Photodynamic antimicrobial chemotherapy, Streptococcus mutans
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2012
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