Caries and gingivitis prevention may benefit from chemotherapeutic plaque control, therefore we compared in a cross–over study with 5 subjects the anti–acidogenic effects of a single use of AmF–SnF2 mouthrinse solutions (Meridol® with and without 5% alcohol) with baseline and with the effects of a placebo and a chlorhexidine mouthrinse (CHX). Buccal plaque was collected 0.5, 3 and 8 h after the subjects used one of the mouthrinses, each time before and after a rinse with 10% sucrose to induce lactic acid production. Samples were analysed for acid anions by capillary electrophoresis and for protein. At 0.5 h after the use of AmF–SnF2 or CHX, the concentration of acetate in resting plaque was 70% lower than at baseline or after using the placebo. Average post–sucrose acetate and lactate concentrations in the placebo group were 30–80% higher than at baseline; up to 3 h this difference was significant. 8 h after using AmF–SnF2 or CHX, the post–sucrose acetate and lactate concentrations were still 30–50% lower than after the placebo, and up to 40% lower than at baseline. To conclude, AmF–SnF2 in both Meridol formulations and CHX were shown to have a similar potency to inhibit acid production after a single rinse.

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